Abstract：
:In this review, published peer-reviewed preclinical studies using prime-boost tuberculosis (TB) vaccine regimens in animal challenge models for tuberculosis have been evaluated. These studies have been divided into groups that describe prime-boost vaccine combinations that performed better than, equivalent to, or worse than the currently used BCG vaccine. Review of the data has revealed interesting findings, including that more than half of the published studies using BCG as a prime combined with a novel boost vaccine give better efficacy than BCG alone and that the greatest reduction in Mycobacterium tuberculosis (M.tb.) colonization of animal tissues is provided by viral vectored vaccines delivered intranasally. Careful evaluation of these data should assist in defining the value of prime-boost regimens for advancement into human TB vaccine trials and stimulate the development of criteria for choosing which vaccine candidates should be studied further.
journal_name
Vaccinejournal_title
Vaccineauthors
Brennan MJ,Clagett B,Fitzgerald H,Chen V,Williams A,Izzo AA,Barker LFdoi
10.1016/j.vaccine.2012.02.036subject
Has Abstractpub_date
2012-04-16 00:00:00pages
2811-23issue
18eissn
0264-410Xissn
1873-2518pii
S0264-410X(12)00219-8journal_volume
30pub_type
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