Large-scale influenza vaccination promotion on a mobile app platform: A randomized controlled trial.

Abstract:

:While health-care providers have used incentives in an attempt to motivate patients to obtain vaccinations, their effect on vaccination rates has not been systematically evaluated on a large scale. In this study, we examined whether mobile applications may improve population vaccination rates through enhanced communication and incentives education. Our study is the first randomized controlled trial assessing the effect of large-scale messaging combined with individualized incentives on influenza-vaccination rates. In this trial, we delivered messages regarding influenza vaccinations to 50,286 adults, aged 18 through 65, then compared the subsequent vaccination rate, the effectiveness of the message content and the timing. Multiple rounds of messaging occurred over a seven-week period during the 2016 flu season, after which vaccination rates were observed for one week. Participants were randomly assigned to one of three messaging approaches: conspicuous (highlighting the amount of rewards to be received for obtaining a flu shot); generic (promoting vaccinations with no mention of rewards); or no-message. Evidence of vaccination obtainment was indicated by medical and pharmacy claims, augmented by patients self-reporting through the mobile wellness app during the study period. Of the people assigned to receive messaging, 23.2% obtained influenza vaccination, compared to 22.0% of people who obtained vaccination in the no-messaging control arm. This difference was statistically significant (p < 0.01). The research revealed that messaging effectiveness decreased after each successive batch sent, suggesting that most participants responsive to messaging would become activated immediately after receiving one alert. Interestingly, in this large-scale study, there were no significant differences between conspicuous incentives and generic messaging, suggesting an important area for future research. Trial Registration: clinicaltrials.gov identifier: NCT02908893.

journal_name

Vaccine

journal_title

Vaccine

authors

Lee WN,Stück D,Konty K,Rivers C,Brown CR,Zbikowski SM,Foschini L

doi

10.1016/j.vaccine.2019.11.053

subject

Has Abstract

pub_date

2020-04-16 00:00:00

pages

3508-3514

issue

18

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(19)31595-6

journal_volume

38

pub_type

杂志文章

相关文献

VACCINE文献大全
  • Stability of an antifertility vaccine consisting of gonadotropin subunits linked to tetanus toxoid.

    abstract::The shelf life and thermal stability of an antifertility vaccine, in which gonadotropin subunits are linked to carriers such as tetanus toxoid and cholera toxin chain B and has successfully completed phase-I clinical trials at five centres in India, was studied. The vaccine adsorbed on alum was stored at three tempera...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/0264-410x(89)90051-0

    authors: Alam A,Singh O,Talwar GP

    更新日期:1989-04-01 00:00:00

  • Estimating the effect of measles vaccination on child growth using 191 DHS from 65 low- and middle-income countries.

    abstract:BACKGROUND:Childhood vaccinations reduce morbidity and mortality and are highly cost-effective. They may also protect children from malnutrition and lead to improved child growth. Stunting, wasting and underweight are targets used to monitor progress towards the achievement of the sustainable development goals (SDGs). ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2019.06.054

    authors: Bogler L,Jantos N,Bärnighausen T,Vollmer S

    更新日期:2019-08-14 00:00:00

  • Strategic health communication on social media: Insights from a Danish social media campaign to address HPV vaccination hesitancy.

    abstract:OBJECTIVE:To evaluate whether the social media strategy developed for the campaign Stop HPV - stop cervical cancer was successful at engaging target groups in communication regarding HPV vaccination. INTRODUCTION:In 2009, the Human Papillomavirus (HPV) vaccine became part of the Danish childhood vaccination program to...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2020.05.061

    authors: Pedersen EA,Loft LH,Jacobsen SU,Søborg B,Bigaard J

    更新日期:2020-06-26 00:00:00

  • Immunogenicity, safety and reactogenicity of the pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in 2-17-year-old children with asplenia or splenic dysfunction: A phase 3 study.

    abstract:BACKGROUND:Immunization with pneumococcal vaccines is an important prophylactic strategy for children with asplenia or splenic dysfunction, who are at high risk of bacterial infections (including S. pneumoniae). This study aimed to assess immunogenicity and safety of pneumococcal non-typeable Haemophilus influenzae pro...

    journal_title:Vaccine

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.vaccine.2017.08.039

    authors: Szenborn L,Osipova IV,Czajka H,Kharit SM,Jackowska T,François N,Habib MA,Borys D

    更新日期:2017-09-25 00:00:00

  • Quadrivalent meningococcal conjugate vaccines.

    abstract::Neisseria meningitidis is an important cause of bacterial meningitis and septicaemia with most disease caused by meningococci bearing serogroups A, B, C, Y and W-135 polysaccharides. Monovalent serogroup C conjugate vaccines have become established in the immunisation programmes in many countries and the first quadriv...

    journal_title:Vaccine

    pub_type: 杂志文章,评审

    doi:10.1016/j.vaccine.2009.05.003

    authors: Pace D,Pollard AJ,Messonier NE

    更新日期:2009-06-24 00:00:00

  • Hepatitis B vaccination: universal vaccination of newborn babies and children at 12 years of age versus high risk groups. A comparison in the field.

    abstract::From 1983 to 1993 two anti-hepatitis B vaccinal strategies were adopted in two small towns of Southern Italy at high incidence for HBV infections: Afragola (prevalence of HBsAg carriers of 13.4%) and Frattamaggiore (prevalence of HBsAg carriers of 12.9%). In Afragola, the universal vaccination of infants in their firs...

    journal_title:Vaccine

    pub_type: 临床试验,杂志文章

    doi:10.1016/0264-410x(95)00056-7

    authors: Da Villa G,Picciottoc L,Elia S,Peluso F,Montanaro F,Maisto T

    更新日期:1995-09-01 00:00:00

  • Neospora caninum antigens displaying virus-like particles as a bivalent vaccine candidate against neosporosis.

    abstract::Neospora caninum is a causative and transmissible agent of dog and bovine neosporosis. The resulting reproductive failures in infected cattle lead to significant economic losses worldwide. However, there is no satisfactory treatment or vaccine currently available to combat this pathogen. Thus, the development of appro...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2019.09.002

    authors: Xu J,Hiramatsu R,Suhaimi H,Kato T,Fujimoto A,Tokiwa T,Ike K,Park EY

    更新日期:2019-10-08 00:00:00

  • Maternal pneumococcal capsular IgG antibodies and transplacental transfer are low in South Asian HIV-infected mother-infant pairs.

    abstract:BACKGROUND:Our understanding of the mother-to-child transfer of serotype-specific pneumococcal antibodies is limited in non-immunized, HIV-positive women. METHODS:We compared geometric mean antibody concentrations (GMCs), geometric mean transplacental cord:maternal ratios (GMRs) and proportions of samples with protect...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2014.01.033

    authors: Gupta A,Mathad JS,Yang WT,Singh HK,Gupte N,Mave V,Bharadwaj R,Zaman K,Roy E,Bollinger RC,Bhosale R,Steinhoff MC

    更新日期:2014-03-14 00:00:00

  • Indicators of therapeutic effect in FIT-06, a Phase II trial of a DNA vaccine, GTU(®)-Multi-HIVB, in untreated HIV-1 infected subjects.

    abstract:BACKGROUND:Combination highly active antiretroviral therapy (HAART) has significantly decreased HIV-1 related morbidity and mortality globally transforming HIV into a controllable condition. HAART has a number of limitations though, including limited access in resource constrained countries, which have driven the searc...

    journal_title:Vaccine

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.vaccine.2012.04.007

    authors: Vardas E,Stanescu I,Leinonen M,Ellefsen K,Pantaleo G,Valtavaara M,Ustav M,Reijonen K

    更新日期:2012-06-08 00:00:00

  • Co-administration of IL-12 DNA with rORFF antigen confers long-term protective immunity against experimental visceral leishmaniaisis.

    abstract::Visceral leishmaniasis, caused by the intracellular parasite Leishmania donovani is a significant public health problem in many regions of the world. Anti-leishmanial immune defences are primarily dependent on the ability of the host to mount an interleukin-12 (IL-12) driven Th1 type of responses. Thus, IL-12 plays a ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2005.11.058

    authors: Tewary P,Saxena S,Madhubala R

    更新日期:2006-03-20 00:00:00

  • Retrospective evaluation of foot-and-mouth disease vaccine effectiveness in Turkey.

    abstract::Foot-and-mouth disease (FMD) is present in much of Turkey and its control is largely based on vaccination. The arrival of the FMD Asia-1 serotype in Turkey in 2011 caused particular concern, spreading rapidly westwards across the country towards the FMD free European Union. With no prior natural immunity, control of s...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2014.01.071

    authors: Knight-Jones TJ,Bulut AN,Gubbins S,Stärk KD,Pfeiffer DU,Sumption KJ,Paton DJ

    更新日期:2014-04-01 00:00:00

  • The potential economic value of a hookworm vaccine.

    abstract::Hookworm infection is a significant problem worldwide. As development of hookworm vaccine proceeds, it is essential for vaccine developers and manufacturers, policy makers, and other public health officials to understand the potential costs and benefits of such a vaccine. We developed a decision analytic model to eval...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2010.12.004

    authors: Lee BY,Bacon KM,Bailey R,Wiringa AE,Smith KJ

    更新日期:2011-02-01 00:00:00

  • Protection against an intranasal challenge by vaccines formulated with native and recombinant preparations of the Chlamydia trachomatis major outer membrane protein.

    abstract::To compare the ability of a native and a recombinant preparation of the major outer membrane protein of Chlamydia trachomatis mouse pneumonitis (MoPn; Ct-nMOMP and Ct-rMOMP) to protect against an intranasal (i.n.) challenge, BALB/c mice were vaccinated by the intramuscular (i.m.) and subcutaneous (s.c.) routes using C...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2009.05.008

    authors: Sun G,Pal S,Weiland J,Peterson EM,de la Maza LM

    更新日期:2009-08-06 00:00:00

  • Improved vaccination against Newcastle disease by an in ovo recombinant HVT-ND combined with an adjuvanted live vaccine at day-old.

    abstract::The continuous outbreaks of fatal Newcastle disease (ND) in commercial poultry flocks demonstrate that current vaccination strategies are not fully efficacious and should be improved by new generation of vaccines. In this context, maternally immune conventional layer chickens were vaccinated in ovo with a turkey herpe...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2009.10.049

    authors: Rauw F,Gardin Y,Palya V,Anbari S,Lemaire S,Boschmans M,van den Berg T,Lambrecht B

    更新日期:2010-01-08 00:00:00

  • Threshold cost-effectiveness analysis for a therapeutic vaccine against HPV-16/18-positive cervical intraepithelial neoplasia in the Netherlands.

    abstract::In this study, the potential price for a therapeutic vaccine against Human Papilloma Virus (HPV)-16 & 18 (pre)-malignant cervical lesions is examined. A decision tree model was built in the context of the new Dutch cervical cancer-screening program and includes a primary test for the presence of HPV. Based on data of ...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2016.10.019

    authors: Luttjeboer J,Setiawan D,Cao Q,Cahh Daemen T,Postma MJ

    更新日期:2016-12-07 00:00:00

  • In vivo and in vitro evidence that cross-reactive antibodies to C-terminus of hypervariable region 1 do not neutralize heterologous hepatitis C virus.

    abstract::The hypervariable region 1 (HVR1) of hepatitis C virus (HCV) may contain neutralizing epitopes. A chimpanzee in whom cross-reactive anti-HVR1 antibodies had been induced by immunization was challenged with heterologous HCV for clarifying whether cross-reactive anti-HVR1 antibodies can neutralize heterologous HCV. Acut...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(02)00271-2

    authors: Esumi M,Zhou YH,Tanoue T,Tomoguri T,Hayasaka I

    更新日期:2002-08-19 00:00:00

  • Testing for AIDS on samples of dried blood prepared on filter papers.

    abstract::A substantial rise in the number of AIDS cases has been observed during the past year in many African countries, and HIV-2 indigenous transmission and increased disease have since gained importance in Senegal. Both for HIV-1 and HIV-2 diagnosis, ELISA positivity is followed by a Western blot test for specific antibodi...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/0264-410x(88)90210-1

    authors: Arya SC

    更新日期:1988-06-01 00:00:00

  • Assessment of influenza vaccine effectiveness in a sentinel surveillance network 2010-13, United States.

    abstract:BACKGROUND:Influenza vaccines are now widely used to reduce the burden of annual epidemics of influenza virus infections. Influenza vaccine effectiveness (VE) is monitored annually to determine VE against each season's circulating influenza strains in different groups such as children, adults and the elderly. Few prosp...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2015.11.016

    authors: Cowling BJ,Feng S,Finelli L,Steffens A,Fowlkes A

    更新日期:2016-01-02 00:00:00

  • Attenuation and protective efficacy of Rift Valley fever phlebovirus rMP12-GM50 strain.

    abstract::Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and the Arabian Peninsula that affects sheep, cattle, goats, camels, and humans. Effective vaccination of susceptible ruminants is important for the prevention of RVF outbreaks. Live-attenuated RVF vaccines are in general highly immunogenic...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2017.10.036

    authors: Ly HJ,Nishiyama S,Lokugamage N,Smith JK,Zhang L,Perez D,Juelich TL,Freiberg AN,Ikegami T

    更新日期:2017-12-04 00:00:00

  • Salmonella Typhimurium lacking the Znuabc transporter is attenuated and immunogenic in pigs.

    abstract::Meat contamination by Salmonella spp. is emerging as a major cause of human enteric infections in industrialized countries. The attempts to reduce human cases of salmonellosis encompass pre- and post-harvest interventions. In this context, vaccination of pigs may represent an effective instrument in eliminating/reduci...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2013.04.032

    authors: Pesciaroli M,Gradassi M,Martinelli N,Ruggeri J,Pistoia C,Raffatellu M,Magistrali CF,Battistoni A,Pasquali P,Alborali GL

    更新日期:2013-06-12 00:00:00

  • Vaccine effectiveness against severe laboratory-confirmed influenza in children: results of two consecutive seasons in Italy.

    abstract:OBJECTIVE:To evaluate the effectiveness of seasonal influenza vaccine in preventing Emergency Department (ED) visits and hospitalisations for influenza like illness (ILI) in children. METHODS:We conducted a test negative case-control study during the 2011-2012 and 2012-2013 influenza seasons. Eleven paediatric hospita...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2014.06.048

    authors: Menniti-Ippolito F,Da Cas R,Traversa G,Santuccio C,Felicetti P,Tartaglia L,Trotta F,Di Pietro P,Barabino P,Renna S,Riceputi L,Tovo PA,Gabiano C,Urbino A,Baroero L,Le Serre D,Virano S,Perilongo G,Daverio M,Gnoato E,

    更新日期:2014-07-31 00:00:00

  • IMP321 (sLAG-3) safety and T cell response potentiation using an influenza vaccine as a model antigen: a single-blind phase I study.

    abstract::sLAG-3 (IMP321), a natural high affinity ligand for MHC class II, was tested for safety, tolerability and its ability to increase Th-1-type T cell responses to a commercial trivalent split influenza vaccine (Agrippal) in a phase I single-blinded, randomized, controlled clinical trial. Twenty healthy volunteers were fi...

    journal_title:Vaccine

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.vaccine.2007.04.019

    authors: Brignone C,Grygar C,Marcu M,Perrin G,Triebel F

    更新日期:2007-06-11 00:00:00

  • Cytoplasmic delivery of antigens, by Bacillus subtilis enhances Th1 responses.

    abstract::Endospores of the Gram-positive bacterium, Bacillus subtilis, have been used successfully for delivery of antigens where the immunogen is expressed on the spore surface. In this work the spore has been engineered to deliver antigens to the cytoplasm of macrophages by expressing listeriolysin O (LLO) or a derivative, L...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2008.09.024

    authors: Huang JM,La Ragione RM,Cooley WA,Todryk S,Cutting SM

    更新日期:2008-11-11 00:00:00

  • Conformational restriction of peptidyl immunogens with covalent replacements for the hydrogen bond.

    abstract::A new strategy for designing synthetic vaccines is presented. In this approach synthetic peptides are conformationally restricted by replacing putative hydrogen bonds with covalent mimics. The chemistry for substituting a hydrazone-ethane link (N-N = CH-CH2-CH2) for an (i + 4)----i hydrogen bond in a pentapeptide with...

    journal_title:Vaccine

    pub_type: 杂志文章,评审

    doi:10.1016/s0264-410x(88)80007-0

    authors: Satterthwait AC,Arrhenius T,Hagopian RA,Zavala F,Nussenzweig V,Lerner RA

    更新日期:1988-04-01 00:00:00

  • Parenteral vaccination of mice and piglets with F4+ Escherichia coli suppresses the enteric anti-F4 response upon oral infection.

    abstract::We studied with a mouse model and in piglets the requirements to prime for a secondary, mucosal B-cell response against Escherichia coli F4 fimbriae, an important virulence factor of enterotoxigenic E. coli, the agent associated with postweaning diarrhoea in piglets. The major observation obtained with the mouse model...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/0264-410x(95)00192-4

    authors: Bianchi AT,Scholten JW,van Zijderveld AM,van Zijderveld FG,Bokhout BA

    更新日期:1996-02-01 00:00:00

  • Combined vaccination against IL-5 and eotaxin blocks eosinophilia in mice.

    abstract::Interleukin-5 (IL-5) is a cytokine which is essential for the maturation of eosinophils in bone marrow and for their release into the blood. Eotaxin is a CC type chemokine implicated in the recruitment of eosinophils in a variety of inflammatory disorders. Since eosinophil-activity is governed by these two pathways, w...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2010.02.048

    authors: Zou Y,Sonderegger I,Lipowsky G,Jennings GT,Schmitz N,Landi M,Kopf M,Bachmann MF

    更新日期:2010-04-19 00:00:00

  • Immunization with recombinant paraflagellar rod protein induces protective immunity against Trypanosoma cruzi infection.

    abstract::In the present study, we have produced recombinant paraflagellar rod proteins (PFR) and report their use for successful vaccination of mice against Trypanosoma cruzi. This protection is associated with a highly polarized type 1 cytokine production profile. Additionally, we have analyzed the gene sequence encoding PFR-...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/s0264-410x(03)00108-7

    authors: Luhrs KA,Fouts DL,Manning JE

    更新日期:2003-06-20 00:00:00

  • Purification of cell culture-derived influenza A virus via continuous anion exchange chromatography on monoliths.

    abstract::The continuously increasing demand for potent and safe vaccines and the intensifying economic pressure on health care systems underlines the need for further optimization of vaccine manufacturing. Here, we focus on downstream processing of human influenza vaccines, investigating the purification of serum-free cell cul...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/j.vaccine.2017.06.086

    authors: Fischer LM,Wolff MW,Reichl U

    更新日期:2018-05-24 00:00:00

  • Recombinant enterotoxins as vaccines against Escherichia coli-mediated diarrhoea.

    abstract::A fusion protein, comprising the B subunit of the heat-labile enterotoxin and a portion of the precursor to the heat-stable enterotoxin of Escherichia coli, has been created by recombinant genetic techniques. It is exported successfully to the bacterial periplasm and assembles into pentamers which retain the ability t...

    journal_title:Vaccine

    pub_type: 杂志文章

    doi:10.1016/0264-410x(93)90022-p

    authors: Aitken R,Hirst TR

    更新日期:1993-01-01 00:00:00

  • Effect of hepatitis A vaccination schedules on immune response.

    abstract::An inactivated hepatitis A vaccine was given to 104 seronegative volunteers aged between 19 and 60 years according to two schedules: 0, 1 and 2 months or 0, 1 and 6 months. The vaccine was well tolerated and 97 and 100% of vaccinees developed a serum antibody response following a single and two doses of vaccine respec...

    journal_title:Vaccine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0264-410x(92)90563-y

    authors: Tilzey AJ,Palmer SJ,Barrow S,Perry KR,Tyrell H,Safary A,Banatvala JE

    更新日期:1992-01-01 00:00:00