Testing for AIDS on samples of dried blood prepared on filter papers.

Abstract:

:A substantial rise in the number of AIDS cases has been observed during the past year in many African countries, and HIV-2 indigenous transmission and increased disease have since gained importance in Senegal. Both for HIV-1 and HIV-2 diagnosis, ELISA positivity is followed by a Western blot test for specific antibodies. The serum samples are stored at sub-zero temperatures both during shipment and storage while awaiting serological testing. Attempts have been made to use dried blood on filter papers for AIDS diagnosis, in 35 samples from Africa and 10 from USA, along with corresponding serum samples. The concordance has been good with an almost invariable ELISA confirmation on Western blot, no selective loss in any of the bands in Western blot and the Pearson coefficient value for ELISA testing on serum and dried blood lots of 0.85. Based on the data obtained during the intentional exposure of blood-impregnated filter papers, from nine HIV-positive and one HIV-negative patient from the USA, to varying temperatures and humidity for different intervals, blood collection on filter paper would appear to have emerged as a satisfactory procedure for HIV seroepidemiological studies.

journal_name

Vaccine

journal_title

Vaccine

authors

Arya SC

doi

10.1016/0264-410x(88)90210-1

subject

Has Abstract

pub_date

1988-06-01 00:00:00

pages

210

issue

3

eissn

0264-410X

issn

1873-2518

pii

0264-410X(88)90210-1

journal_volume

6

pub_type

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