Safety and immunogenicity of a high dosage trivalent influenza vaccine among elderly subjects.

abstract：BACKGROUND:High incidence and serotype diversity of invasive pneumococcal disease (IPD) in Indigenous children in remote Australia led to rapid introduction of 7-valent conjugate pneumococcal vaccine (7vPCV) at 2, 4 and 6 months in 2001, followed by 23-valent polysaccharide pneumococcal vaccine (23vPPV) in the second y...

journal_title：Vaccine

authors： Jayasinghe S,Chiu C,Menzies R,Lehmann D,Cook H,Giele C,Krause V,McIntyre P

更新日期：2015-11-27 00:00:00

abstract：:Rabies virus remains an important burden of disease claiming an estimated 60,000 lives each year, mainly children, and having a huge economical and societal cost. Post-exposure prophylaxis (PEP) is highly effective, however in patients that present with neurological symptoms the case-fatality ratio is extremely high (...

journal_title：Vaccine

authors： Jochmans D,Neyts J

更新日期：2019-08-02 00:00:00

abstract：:The necessity of avoiding the use of animals in vaccine potency testing has been widely recognized. The repeatability and reproducibility of the Expected Percentage of Protection (EPP) as a serological potency surrogate for A24 Cruzeiro foot-and-mouth disease virus (FMDV) strain was assessed, and compared with the res...

journal_title：Vaccine

authors： Robiolo B,La Torre J,Maradei E,Beascoechea CP,Perez A,Seki C,Smitsaart E,Fondevila N,Palma E,Goris N,De Clercq K,Mattion N

更新日期：2010-08-31 00:00:00

abstract：:The effects on the immunity in cattle of dosage and storage of oil-based inactivated vaccine incorporating the Gladysdale strain were examined. Storage at 4 degrees C for 12 or 24 months was found not to have any marked effect on the immunity conferred in the vaccinated cattle. A dosage of 0.5 ml was found to be as ef...

journal_title：Vaccine

authors： Garba SA,Terry RJ

更新日期：1986-12-01 00:00:00

abstract：:We report that intraperitoneal injection of Chlamydia pneumoniae purified elementary bodies (EBs) in the hamster causes a systemic infection allowing the isolation of viable chlamydiae from several organs for several days post-infection (p.i.). In particular, spleen infection occurred up to Day 7 p.i. in 100% of anima...

journal_title：Vaccine

authors： Sambri V,Donati M,Storni E,Di Leo K,Agnusdei M,Petracca R,Finco O,Grandi G,Ratti G,Cevenini R

更新日期：2004-03-12 00:00:00

abstract：:Mumps virus is still circulating and annual mumps outbreaks occur with fluctuating magnitudes in Japan. Aseptic meningitis has been reported after vaccination and it would be of importance to determine whether this was related to the vaccination. The objective of this study was to develop a sensitive, specific and rap...

journal_title：Vaccine

authors： Yoshida N,Fujino M,Ota Y,Notomi T,Nakayama T

更新日期：2007-01-26 00:00:00

abstract：:In 2004, we conducted a study in Piemonte (Italy), in order to describe incidence, treatment, hospitalizations and costs of herpes zoster (HZ), in population over 14 years of age. Twenty-four regional general practitioners, with 26,394 patients >14 years in charge (0.71% of the regional population), reported prospecti...

journal_title：Vaccine

authors： Di Legami V,Gianino MM,Ciofi degli Atti M,Massari M,Migliardi A,Tomba GS,Zotti C,Zoster Study Group.

更新日期：2007-10-23 00:00:00

abstract：BACKGROUND:Nasal vaccination is considered to be a promising alternative for parenteral vaccination against influenza virus as it is non-invasive and offers the opportunity to elicit strong antigen-specific responses both systemic and locally at the port of entry of the pathogen. Previous studies showed that non-living...

journal_title：Vaccine

authors： Keijzer C,Haijema BJ,Meijerhof T,Voorn P,de Haan A,Leenhouts K,van Roosmalen ML,van Eden W,Broere F

更新日期：2014-05-19 00:00:00

abstract：:Actinobacillus pleuropneumoniae is an important respiratory pathogen of swine, for which there is no highly effective vaccine. A phage expression library of the A. pleuropneumoniae genome was constructed and screened to identify potential vaccine components. Open reading frames within immuno-reactive phage were analyz...

journal_title：Vaccine

authors： Oldfield NJ,Donovan EA,Worrall KE,Wooldridge KG,Langford PR,Rycroft AN,Ala'Aldeen DA

更新日期：2008-04-07 00:00:00

abstract：:Measles, mumps and rubella (MMR) vaccination coverage in Italy has been decreasing starting from 2012 and, at the present, none of the Italian regions has achieved the goal of 95% coverage target. A decision of the Court of Justice of Rimini in March 2012 that awarded vaccine-injury compensation for a case of autism h...

journal_title：Vaccine

authors： Aquino F,Donzelli G,De Franco E,Privitera G,Lopalco PL,Carducci A

更新日期：2017-08-16 00:00:00

abstract：:Immunisation is one of the corner stones of public health. Most health care consumers see the health care worker as their major source of information on immunisation and vaccine safety. Doctors, nurses and midwives should be appropriately and timely trained for that role. Within the Vaccine Safety, Attitudes, Training...

journal_title：Vaccine

authors： Vorsters A,Tack S,Hendrickx G,Vladimirova N,Bonanni P,Pistol A,Metlicar T,Pasquin MJ,Mayer MA,Aronsson B,Heijbel H,Van Damme P

更新日期：2010-02-25 00:00:00

abstract：:Influenza is a significant cause of morbidity and mortality for pregnant women and infants worldwide. Influenza vaccination during pregnancy has been shown to be safe and highly effective and should be recommended for all pregnant women before the influenza season. Despite existing recommendations, the vaccine is unde...

journal_title：Vaccine

authors： Blanchard-Rohner G,Siegrist CA

更新日期：2011-10-06 00:00:00

abstract：:We report the results of the handsearch of all the issues of Vaccine from 1983 to 1994 to identify randomized and controlled clinical trials (RCTs and CCTs) with the aim of setting up a Cochrane data base of vaccine trials. We read 1119 original papers and located 231 trials of which 117 (50.6%) were RCTs and 114 (49....

journal_title：Vaccine

authors： Jefferson T,Jefferson V

更新日期：1996-04-01 00:00:00

abstract：:The FML antigen of Leishmania donovani, in combination with either Riedel de Haën (R), QuilA, QS21 saponins, IL12 or BCG, was used in vaccination of an outbred murine model against visceral leishmaniasis (VL). Significant and specific increases in anti-FML IgG and IgM responses were detected for all adjuvants, and in ...

journal_title：Vaccine

authors： Santos WR,de Lima VM,de Souza EP,Bernardo RR,Palatnik M,Palatnik de Sousa CB

更新日期：2002-11-22 00:00:00

abstract：:Plague is a zoonotic disease caused by Yersinia pestis, an etiological agent of pneumonic and bubonic plague. There is a need for an improved plague vaccine that may overcome the limitation of presently available whole cell vaccine. An alternative approach described here, is the use of protective epitopes from immunod...

journal_title：Vaccine

authors： Tripathi V,Chitralekha KT,Bakshi AR,Tomar D,Deshmukh RA,Baig MA,Rao DN

更新日期：2006-04-12 00:00:00

abstract：OBJECTIVE:Uptake of meningococcal vaccine (MCV) and tetanus, diphtheria and pertussis (Tdap) vaccine among adolescents has approached Healthy People 2020 goals, but human papillomavirus (HPV) vaccination has not. This study evaluated an intervention using the 4 Pillars™ Practice Transformation Program to increase HPV, ...

journal_title：Vaccine

authors： Zimmerman RK,Moehling KK,Lin CJ,Zhang S,Raviotta JM,Reis EC,Humiston SG,Nowalk MP

更新日期：2017-01-03 00:00:00

abstract：:HIV vaccines of the first generation are, in contrast to most currently licensed vaccines, unlikely to provide sterilizing immunity against infection with HIV. However, they are expected to exert a beneficial effect on the maintenance of CD4 T-cell counts by reducing viral load. There is a recognized need for clarifyi...

journal_title：Vaccine

authors： Fruth U

更新日期：2009-03-23 00:00:00

abstract：:We previously reported the development of an oral vaccine for diabetes based on live attenuated Salmonella-expressing preproinsulin (PPI) as the autoantigen. When combined with host cell-expressed TGFβ, the vaccine prevented the onset of diabetes in non-obese diabetic (NOD) mice. Herein, we investigated factors that c...

journal_title：Vaccine

authors： Husseiny MI,Du W,Mbongue J,Lenz A,Rawson J,Kandeel F,Ferreri K

更新日期：2018-12-18 00:00:00

abstract：:sLAG-3 (IMP321), a natural high affinity ligand for MHC class II, was tested for safety, tolerability and its ability to increase Th-1-type T cell responses to a commercial trivalent split influenza vaccine (Agrippal) in a phase I single-blinded, randomized, controlled clinical trial. Twenty healthy volunteers were fi...

journal_title：Vaccine

authors： Brignone C,Grygar C,Marcu M,Perrin G,Triebel F

更新日期：2007-06-11 00:00:00

abstract：:To generate CD4+ T-helper cell lines, lymphocytes from HIV-seronegative subjects were primed in vitro with peptides derived from the V3 loop of HIV-1 gp120. Antigen-specific reactivity was inhibited by an anti-DR monoclonal antibody, indicating HLA-class II dependency, but peptides could be recognized in different HLA...

journal_title：Vaccine

authors： Billaud JN,Yagello M,Gluckman JC

更新日期：1994-01-01 00:00:00

abstract：:Early studies using DNA immunization suggest the potential benefits of this form of immunization including: long-lived immunity, a broad spectrum of immune responses (both cell-mediated immunity and humoral responses) and the simultaneous induction of immunity to a variety of pathogens through the use of multivalent v...

journal_title：Vaccine

authors： van Drunen Littel-van den Hurk S,Loehr BI,Babiuk LA

更新日期：2001-03-21 00:00:00

abstract：:We have designed a peptide-based immunotherapeutic vaccine for treatment of androgen-responsive prostate cancer. The vaccine targets the luteinizing hormone-releasing hormone (LHRH) decapeptide that results in an androgen-deprivation immunotherapy. The design elements of the peptide immunogens are the LHRH peptide or ...

journal_title：Vaccine

authors： Finstad CL,Wang CY,Kowalski J,Zhang M,Li ML,Li XM,Xia WG,Bosland MC,Murthy KK,Walfield AM,Koff WC,Zamb TJ

更新日期：2004-03-12 00:00:00

abstract：:In a phase III, double blind, randomized, noninferiority, multi-centre clinical trial, 817 infants were included and randomly assigned to vaccination with DTaP-IPV(Vero) (N=410) or DTaP-IPV(Mkc) (N=407) vaccines (Statens Serum Institut (SSI), Denmark) in the right thigh. All infants were vaccinated with Act-HIB (Sanof...

journal_title：Vaccine

authors： Pietrzyk JJ,Wysocki J,Pejcz J,Galaj A,Majda-Stanislawska E,Käyhty H,Thierry-Carstensen B,Jensen AM

更新日期：2008-09-26 00:00:00

abstract：:The aim was to develop T cell costimulatory molecules that are broadly applicable to augment anti-tumor immune responses upon application of a virus-modified tumor vaccine to cancer patients. We generated recombinant bispecific single-chain antibodies with one specificity directed against the CD3 or the CD28 antigen o...

journal_title：Vaccine

authors： Haas C,Lulei M,Fournier P,Arnold A,Schirrmacher V

更新日期：2005-03-31 00:00:00

abstract：:Rotavirus vaccine was introduced in El Salvador in 2006 and is recommended to be given concomitantly with DTP-HepB-Haemophilus influenzae type b (pentavalent) vaccine at ages 2 months (upper age limit 15 weeks) and 4 months (upper age limit 8 months) of age. However, rotavirus vaccination coverage continues to lag beh...

journal_title：Vaccine

authors： Suarez-Castaneda E,Burnett E,Elas M,Baltrons R,Pezzoli L,Flannery B,Kleinbaum D,de Oliveira LH,Danovaro-Holliday MC

更新日期：2015-11-27 00:00:00

abstract：:The effect of sublethal gamma-ray irradiation on the protection conferred by a nasal influenza vaccine was investigated in BALB/c mice. A radiation dose of 7 Gy was selected as the sublethal dose as this caused exacerbation of the influenza but was not lethal in the mouse model. Mice were irradiated 7 days before, on ...

journal_title：Vaccine

authors： Hasegawa H,Kadowaki S,Takahashi H,Iwasaki T,Tamura S,Kurata T

更新日期：2000-05-22 00:00:00

abstract：BACKGROUND:It is known that antineoplastic treatment may induce secondary immunodeficiency, but studies after childhood sarcoma are rare. Since 1998, the Late Effects Surveillance System (LESS) of the German Society for Paediatric Oncology and Haematology (GPOH) prospectively registers late effects in soft tissue-, ost...

journal_title：Vaccine

authors： Paulides M,Stöhr W,Laws HJ,Graf N,Lakomek M,Berthold F,Schmitt K,Niggli F,Jürgens H,Bielack S,Koscielniak E,Klingebiel T,Langer T

更新日期：2011-02-11 00:00:00

abstract：:DNA vectors can be used to deliver vaccine antigens that stimulate effective protective immunity in mice, but in larger, outbred animal species, the protective efficacy is lower or large doses of DNA are required. These data demonstrate that porcine interleukin-3 (IL-3) when delivered to pigs by DNA vector or in low d...

journal_title：Vaccine

authors： Andrew M,Morris K,Coupar B,Sproat K,Oke P,Bruce M,Broadway M,Morrissy C,Strom D

更新日期：2006-04-12 00:00:00

abstract：:Group A Streptococcus (GAS) infections represent a major public health burden in both developing and developed countries. In Australia and New Zealand GAS associated diseases are serious problems in Indigenous populations and a major cause of health inequality. Political recognition of these inequalities is providing ...

journal_title：Vaccine

authors： Moreland NJ,Waddington CS,Williamson DA,Sriskandan S,Smeesters PR,Proft T,Steer AC,Walker MJ,Baker EN,Baker MG,Lennon D,Dunbar R,Carapetis J,Fraser JD

更新日期：2014-06-24 00:00:00

abstract：:Mathematical models of HPV vaccine effectiveness and cost-effectiveness have produced conflicting results. The aim of this study was to use mathematical models to compare and isolate the impact of the assumptions most commonly made when modeling the effectiveness of HPV vaccines. Our results clearly show that differen...

journal_title：Vaccine

authors： Van de Velde N,Brisson M,Boily MC

更新日期：2010-07-26 00:00:00