Abstract：
:Age related deterioration in the function of the immune system has been recognised in many species. The clinical presentations of such immune dysfunction are an age-related increased susceptibility to certain infections, and an increased incidence of autoimmune disease and certain cancers. Laboratory investigations reveal a reduced ability of the cells from older individuals, compared with younger individuals, to perform in functional in vitro assays. These manifestations are thought to be causally linked to an age associated involution of the thymus, which precedes the onset of immune dysfunction. Hypotheses to account for the age-related changes in the thymus include: (i) an age related decline in the supply of T cell progenitors from the bone marrow (ii) an intrinsic defect in the marrow progenitors, or (iii) problems with rearrangement of the TCR beta chain because of a defect in the environment provided by the thymus. We have analysed these possible options in normal mice and also in mice carrying a transgenic T cell receptor. The results from these studies reveal no age related decline either in the number of function of T cell progenitors in the thymus, but changes in the thymic environment in terms of the cytokines produced. We have shown that specific cytokine replacement therapy leads to an increase in thymopoiesis in old animals.
journal_name
Vaccinejournal_title
Vaccineauthors
Aspinall R,Andrew Ddoi
10.1016/s0264-410x(99)00498-3subject
Has Abstractpub_date
2000-02-25 00:00:00pages
1629-37issue
16eissn
0264-410Xissn
1873-2518pii
S0264-410X(99)00498-3journal_volume
18pub_type
杂志文章,评审相关文献
VACCINE文献大全abstract：:Native porcine zona pellucida (PZP) has been shown to be highly effective as an immunocontraceptive in white-tailed deer. However, the immunogenicity of PZP extracted from pig ovaries may vary from lot to lot and the extract has the potential of containing either viral or pathogenic material. Determination of the immu...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(02)00195-0
更新日期：2002-06-21 00:00:00
abstract：:Studies conducted at neonatal intensive care units in Pune, western India, suggested early exposure to rotaviruses and predominance of unusual human-bovine-like G12P[11] strains. The whole genome sequencing and phylogenetic analyses of a naturally attenuated, culture adapted neonatal strain, (NIV-1740121) revealed mul...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.01.081
更新日期：2020-02-28 00:00:00
abstract：:Because of delays in the manufacturing of the 2000-2001, trivalent inactivated influenza vaccine in the US, there were concerns that there might be shortages of vaccine supply in the US. Therefore, we conducted a prospective, randomized, open-label, multicenter trial at six academic medical centers in the US, to evalu...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0264-410x(01)00440-6
更新日期：2002-01-15 00:00:00
abstract：BACKGROUND:Hepatitis B (HepB) vaccination is the most effective measure to prevent HBV infection. Routine HepB vaccination was recommended for infants in 1991 and catch-up vaccination has been recommended for adolescents since in 1995. The purpose of this study is to assess HepB vaccination among adolescents 13-17 year...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.02.021
更新日期：2015-04-08 00:00:00
abstract：:Herpes simplex virus (HSV) infections are common but there is no vaccine available. We evaluated cationic liposome-DNA complexes (CLDC) as an adjuvant for an HSV gD2 vaccine and compared it to an MPL/Alum adjuvant in a guinea pig model of genital herpes. The addition of CLDC to the gD2 vaccine significantly decreased ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.10.025
更新日期：2010-05-07 00:00:00
abstract：:A recombinant fowlpox vaccine with an H5 hemagglutinin gene insert protected chickens against clinical signs and death following challenge by nine different highly pathogenic H5 avian influenza viruses. The challenge viruses had 87.3 to 100% deduced hemagglutinin amino acid sequence similarity with the recombinant vac...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(99)00369-2
更新日期：2000-01-06 00:00:00
abstract：:To investigate the 1918/19 influenza pandemic daily number of new hospitalizations in the only hospital in Florence (Central Italy) were analyzed. In order to describe the transmission dynamics of the 1918/1919 pandemic influenza a compartmental epidemic model was used. Model simulations show a high level of agreement...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.02.049
更新日期：2011-07-22 00:00:00
abstract：:Norovirus (NoV) and hepatitis E virus (HEV) are both enterically-transmitted viruses causing gastroenteritis and hepatitis, respectively, in humans. While a vaccine against HEVs recently became available in China, there is no prophylactic or therapeutic approach against NoVs. Both NoV and HEV have surface protrusions ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2013.11.064
更新日期：2014-01-16 00:00:00
abstract：:DNA vectors can be used to deliver vaccine antigens that stimulate effective protective immunity in mice, but in larger, outbred animal species, the protective efficacy is lower or large doses of DNA are required. These data demonstrate that porcine interleukin-3 (IL-3) when delivered to pigs by DNA vector or in low d...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.01.023
更新日期：2006-04-12 00:00:00
abstract：:We report that intraperitoneal injection of Chlamydia pneumoniae purified elementary bodies (EBs) in the hamster causes a systemic infection allowing the isolation of viable chlamydiae from several organs for several days post-infection (p.i.). In particular, spleen infection occurred up to Day 7 p.i. in 100% of anima...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2003.09.035
更新日期：2004-03-12 00:00:00
abstract：:The virulence and immunogenicity of a wild-type respiratory syncytial (RS) virus together with four temperature sensitive (ts) mutants derived from this isolate were tested by intranasal inoculation into adult volunteers. Resistance to challenge correlated with neutralizing antibody titres in nasal secretions and to a...
journal_title：Vaccine
pub_type： 临床试验,杂志文章
doi：10.1016/0264-410x(90)90051-m
更新日期：1990-06-01 00:00:00
abstract：:Immunization of pregnant women against influenza is a promising strategy to protect the mother, fetus, and young infant from influenza-related diseases. The burden of influenza during pregnancy, the vaccine immunogenicity during this period, and the robust influenza vaccine safety database underpin recommendations tha...
journal_title：Vaccine
pub_type： 共识发展会议,杂志文章
doi：10.1016/j.vaccine.2012.09.034
更新日期：2012-11-26 00:00:00
abstract：:Brucella abortus RB51 is a rough (R) stable vaccine strain used in cattle and is believed to be devoid of O-side chain. We analyzed by use of a panel of monoclonal antibodies (MAbs) directed against seven previously defined O-polysaccharide (O-PS) epitopes the O-chain expression in strain RB51. Two MAbs specific for t...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(02)00035-x
更新日期：2002-03-15 00:00:00
abstract：BACKGROUND:The development of a vaccine against the human gastric pathogen Helicobacter pylori, the main causative agent of gastric adenocarcinoma, has been hampered by a number of issues, including the lack of a mucosal adjuvant for use in humans. Heat shock proteins (Hsp), highly conserved molecules expressed by both...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.02.051
更新日期：2014-04-25 00:00:00
abstract：:Spores of the genus Bacillus have been used for a long time as probiotics for oral bacteriotherapy both in humans and in animals. Spores are also employed in a veterinary vaccine against anthrax. Despite this long lasting and extensive use, the specific contribution of spores to the beneficial effects of probiotics an...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/s0264-410x(03)00207-x
更新日期：2003-06-01 00:00:00
abstract：:The influenza immunization program in North America has been primarily designed to provide direct benefit to vaccinated individuals at highest risk of serious influenza outcomes. Some evidence suggests that immunization of certain age groups may also extend indirect protective benefit to vulnerable populations. Our go...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.11.090
更新日期：2008-03-04 00:00:00
abstract：:We have evaluated in C57/Bl6 and HLA-A2.1 transgenic mice the immunogenicity of three MVA vectors expressing either native HCV E1E2 polyprotein, truncated and secreted E1 (E'1(311)) and E2 (E'2(661)) proteins, or a chimeric E1E2 heterodimer presented at the plasma membrane. Immunization induced mainly a Th1 response i...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2004.04.005
更新日期：2004-09-28 00:00:00
abstract：OBJECTIVE:To assess the effectiveness of the monovalent rotavirus vaccine (RV1) to prevent rotavirus diarrhea admissions to emergency departments (ED) in Colombia. METHODS:A multicenter case-control study was carried out in six Colombian cities from 2011 to January, 2013. Cases were laboratory confirmed rotavirus diar...
journal_title：Vaccine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.vaccine.2014.03.064
更新日期：2014-05-23 00:00:00
abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a potent immune stimulant when administered with different vaccines. Optimal use of GM-CSF resides in its ability to act locally to stimulate the proliferation and maturation of professional antigen-presenting cells (APCs) (i.e., Langerhans' cells) at the in...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2004.11.060
更新日期：2005-04-22 00:00:00
abstract：BACKGROUND:While childhood vaccines are safe and effective, some parents remain hesitant to vaccinate their children, which has led to outbreaks of vaccine preventable diseases. The goal of this systematic review was to identify and summarize the range of beliefs around childhood vaccines elicited using open-ended ques...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2019.08.068
更新日期：2019-10-23 00:00:00
abstract：BACKGROUND:Vaccine coverage estimates lag by years in the US. Commercially available medical claims databases contain timely records of childhood vaccinations given in physician offices. We used such data to track the replacement of the 7-valent pneumococcal conjugate vaccine (PCV7) by PCV13, a new vaccine active again...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2013.10.038
更新日期：2013-12-05 00:00:00
abstract：INTRODUCTION:Widespread introduction of pneumococcal conjugated vaccines (PCVs) impacted on invasive pneumococcal disease (IPD). However, IPD reduction may not be similar in all outcomes within IPD. We assessed PCV7/PCV13 impact on pneumococcal meningitis, bacteremic pneumonia (BP) and other (non-meningitis, non-pneumo...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.05.059
更新日期：2018-08-28 00:00:00
abstract：:The Lister (Elstree) strain of vaccinia virus, used in Israel for vaccination against smallpox, was studied in tissue cultures and in a mouse model. The virus failed to reach the brain of the mice when inoculated intranasally at a dose of 500,000 plaque forming units, but was lethal for 50% of them, when injected intr...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.02.012
更新日期：2006-05-08 00:00:00
abstract：:Patients with malignancies are considered to be at increased risk of acquiring influenza. Because of higher complication and case fatality rates, preventive measures such as vaccination are of great interest. The objective of this study was to assess the acceptability, tolerability and immunogenicity of an adjuvant-fr...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.09.005
更新日期：2012-11-06 00:00:00
abstract：:The identification of new vaccine candidates for leptospirosis is of great interest. This paper describes the identification of two homologous immunogenic proteins, LigA-m and LigB-m, of Leptospira interrogans serovar manilae strain UP-MMC-NIID, which show strong similarity with LigA found recently in L. interrogans s...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2003.10.007
更新日期：2004-03-29 00:00:00
abstract：:The challenges of the journey from target identification through development of a prophylactic quadrivalent human papillomavirus (HPV) vaccine have been met in Gardasil. Cervical cancer is the second leading cause of cancer-related death in women worldwide. Approximately 70% of cervical cancer is caused by infection w...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2007.01.013
更新日期：2007-04-20 00:00:00
abstract：:Insoluble, nanostructured delta inulin particles enhance the immunogenicity of co-administered protein antigens and consequently are used as a vaccine adjuvant (Advax™). To better understand their immunomodulatory properties, the in vitro hydrolysis and in vivo distribution of delta inulin particles were investigated....
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.06.045
更新日期：2017-08-03 00:00:00
abstract：:We reported previously on the development of a Bacillus anthracis vaccine strain expressing high levels of recombinant protective antigen (rPA) [Cohen et al., Infec Immun 2000;68(8):4549-58]. To further explore the potential of the B. anthracis platform, we generated several attenuated strains expressing lethal toxin ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2004.11.077
更新日期：2005-12-01 00:00:00
abstract：:Bovine herpesvirus-1 (BHV-1) glycoprotein D (gD), an envelope glycoprotein, engenders mucosal and systemic immunity protecting cattle from viral infection. Production of gD with authentic immunogenicity is required for a subunit vaccine. We placed the truncated BHV-1 gD gene, lacking its putative transmembrane and cyt...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(96)00234-4
更新日期：1997-04-01 00:00:00
abstract：:Although studies have suggested that a patient's perceived cost-benefit of a medical intervention could affect his or her utilization of the intervention, the economic value of influenza vaccine from the patient's perspective remains unclear. Therefore, we developed a stochastic decision analytic computer model repres...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.12.078
更新日期：2011-03-03 00:00:00
