Progress towards a vaccine against Ebola to meet emergency medical countermeasure needs.

abstract：:Japanese rabies vaccine, a purified chick embryo cell vaccine manufactured by Kaketsuken (PCEC-K), is normally given subcutaneously; however, this requires a large amount of vaccine, and the pre-exposure vaccination regimen requires 6 months to complete. These factors often hamper appropriate vaccination. Therefore, w...

journal_title：Vaccine

authors： Shiota S,Khawplod P,Ahmed K,Mifune K,Nishizono A

更新日期：2008-11-25 00:00:00

abstract：:The purpose of the present research work is to explore the potential of dendrosomes in genetic immunization against hepatitis B. Plasmid DNA encoding pRc/CMV-HBs[S] (5.6 kb), encoding the small region of the hepatitis B surface antigen, was complexed with 5th generation poly(propyleneimine) dendrimer (PPI) in differen...

journal_title：Vaccine

authors： Dutta T,Garg M,Jain NK

更新日期：2008-06-25 00:00:00

abstract：:Lactobacillus spp. comprise a large group of Gram-positive lactic acid bacteria with varying physiological, ecological and immunomodulatory properties that are widely exploited by mankind, primarily in food production and as health-promoting probiotics. Recent years have shown increased interest in using lactobacilli ...

journal_title：Vaccine

authors： Kuczkowska K,Øverland L,Rocha SDC,Eijsink VGH,Mathiesen G

更新日期：2019-10-08 00:00:00

abstract：:Human metapneumovirus (HMPV) expresses the major surface glycoproteins F and G. We evaluated the protective efficacy of immunization with G. We generated a recombinant form of G ectodomain (GDeltaTM) that was secreted from mammalian cells and purified by affinity chromatography. We tested the immunogenicity of GDeltaT...

journal_title：Vaccine

authors： Ryder AB,Tollefson SJ,Podsiad AB,Johnson JE,Williams JV

更新日期：2010-06-07 00:00:00

abstract：:The overall burden of illness from diseases for which vaccines are available disproportionately falls on adults. Adults are recommended to receive vaccinations based on their age, underlying medical conditions, lifestyle, prior vaccinations, and other considerations. Updated vaccine recommendations from CDC are publis...

journal_title：Vaccine

authors： Bridges CB,Hurley LP,Williams WW,Ramakrishnan A,Dean AK,Groom AV

更新日期：2015-11-27 00:00:00

abstract：:Measles has been reemerging in South Korea since December 2018 resulting in 185 cases by September 2019. We calculated contact-adjusted immunity levels against measles in South Korea using national seroprevalence data in 2014, vaccination uptake rates, and an age-specific contact matrix. We further explored options to...

journal_title：Vaccine

authors： Chun JY,Park WB,Kim NJ,Choi EH,Funk S,Oh MD

更新日期：2020-01-10 00:00:00

abstract：BACKGROUND:Measles is a highly infectious respiratory disease which causes 122,000 deaths annually. Although measles vaccine is extremely safe and effective, vaccine coverage could be improved by a vaccine that is more easily administered and transported. We developed an inhalable dry powder measles vaccine (MVDP) and ...

journal_title：Vaccine

authors： MVDP author group.,Cape S,Chaudhari A,Vaidya V,Mulay R,Agarkhedkar S,Shermer C,Collins M,Anderson R,Agarkhedkar S,Kulkarni PS,Winston S,Sievers R,Dhere RM,Gunale B,Powell K,Rota PA,Papania M

更新日期：2014-11-28 00:00:00

abstract：:Development of salivary antibodies at the age of 4 or 5 years to group A and C meningococcal polysaccharides (MenA/C PS) was studied among Gambian children, who had received MenA/C conjugate or PS vaccine in infancy. There was also a control group of 64 age matched children. IgG, IgA, and secretory Ig concentrations w...

journal_title：Vaccine

authors： Nurkka A,MacLennan J,Jäntti V,Obaro S,Greenwood B,Käyhty H

更新日期：2000-10-15 00:00:00

abstract：:Poor routine immunization coverage in India has led to a large burden of vaccine-preventable diseases borne by children under 5 years of age. Despite efforts to strengthen infrastructure and service delivery in the past decade, immunization coverage rates have reached a plateau. To meet the formidable needs of India's...

journal_title：Vaccine

authors： Patel AR,Nowalk MP

更新日期：2010-01-08 00:00:00

abstract：:Pediatric patients with severe chronic kidney disease (CKD) on conservative treatment, on dialysis, and those with renal transplantation are at a higher risk for infectious diseases as the result of impaired immune responses against infectious agents. Infections in these patients can have drastic consequences for dise...

journal_title：Vaccine

authors： Esposito S,Mastrolia MV,Prada E,Pietrasanta C,Principi N

更新日期：2014-11-20 00:00:00

abstract：:The low-molecular-mass secretory proteins of Mycobacterium tuberculosis have been shown to be major T-cell antigens during infection with the pathogenic bacterium. In this study, we determined murine T-cell epitopes on three low-molecular-mass proteins, CFP11 (Rv2433c), CFP17 (Rv1827), and TB18.5 (Rv0164) using DNA im...

journal_title：Vaccine

authors： Eweda G,Suzuki D,Nagata T,Tsujimura K,Koide Y

更新日期：2010-06-23 00:00:00

abstract：:A capture IgE assay in EIA with diphtheria toxin and tetanus toxoid as model systems was developed and evaluated in relation to RIA in a DT booster study. The EIA and the RIA gave very similar results, although the EIA determined IgE over a wider range of concentrations, without interference by other subclasses. The c...

journal_title：Vaccine

authors： Wahren E,Bengtsson C,Björkstén B,Mark A,Granström M

更新日期：1998-05-01 00:00:00

abstract：:Fish has a soluble form of TLR5 ortholog (TLR5S), which does not exist in mammals. We identified TLR5S from rainbow trout and named rtTLR5S, which was about 38% homologous to the extracellular domains of human (hu) and mouse TLR5. Adjuvancy of rtTLR5S to flagellin response by human TLR5 (huTLR5) was tested in this stu...

journal_title：Vaccine

authors： Tsujita T,Ishii A,Tsukada H,Matsumoto M,Che FS,Seya T

更新日期：2006-03-15 00:00:00

abstract：:Epidermal powder immunization (EPI) can efficiently deliver powdered protein vaccines to the epidermis. A phase I clinical trial was conducted to evaluate powdered trivalent influenza vaccine delivered using the PowderJect ND5.2 delivery system. Subjects received either Fluvirin IM injection (15 microg of each influen...

journal_title：Vaccine

authors： Dean HJ,Chen D

更新日期：2004-12-16 00:00:00

abstract：:Group A rotavirus (RVA) is a major cause of diarrhea and diarrhea-related mortality in foals in parts of the world. In addition to careful horse farm management, vaccination is the only known alternative to reduce the RVA associated disease burden on horse farms. The precise evaluation of vaccine effectiveness against...

journal_title：Vaccine

authors： Papp H,Matthijnssens J,Martella V,Ciarlet M,Bányai K

更新日期：2013-11-19 00:00:00

abstract：:The cattle tick, Rhipicephalus microplus, is regarded as the most economically important ectoparasite of livestock globally. Control is achieved primarily through the use of acaricides. This approach is hampered by the development of resistance to commercial acaricides among cattle tick populations. Vaccination agains...

journal_title：Vaccine

authors： Andreotti R,Cunha RC,Soares MA,Guerrero FD,Leite FP,de León AA

更新日期：2012-10-19 00:00:00

abstract：BACKGROUND:A randomized, double-blind, placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a pentavalent live human-bovine reassortant rotavirus vaccine (RotaTeq™, RV5) against rotavirus gastroenteritis (RVGE). METHODS:4040 participants aged 6-12weeks were...

journal_title：Vaccine

authors： Mo Z,Mo Y,Li M,Tao J,Yang X,Kong J,Wei D,Fu B,Liao X,Chu J,Qiu Y,Hille DA,Nelson M,Kaplan SS

更新日期：2017-10-13 00:00:00

abstract：:While the large majority of parents in the U.S. vaccinate their children according to the recommended immunization schedule, some parents have refused or delayed vaccinating, often citing safety concerns. In response to public concern, the U.S. Institute of Medicine (IOM) evaluated existing research regarding the safe...

journal_title：Vaccine

authors： Glanz JM,Newcomer SR,Jackson ML,Omer SB,Bednarczyk RA,Shoup JA,DeStefano F,Daley MF

更新日期：2016-02-15 00:00:00

abstract：:Outer membrane proteins (OMP) are expressed in Gram-negative bacterial cell wall. OmpA from Klebsiella pneumoniae (KpOmpA) has been shown to bind and to activate selectively antigen presenting cells (APCs), eliciting protective CTL responses. In this study, we investigated whether OmpX, another member of the OMP famil...

journal_title：Vaccine

authors： Maisnier-Patin K,Malissard M,Jeannin P,Haeuw JF,Corbière JC,Hoeffel G,Gauchat JF,Nguyen T,Saez JM,Delneste Y

更新日期：2003-09-08 00:00:00

abstract：:Previously, the Fiji Pneumococcal Project (FiPP) evaluated reduced dose immunization schedules that incorporated pneumococcal protein conjugate and/or polysaccharide vaccine (PCV7 and 23vPPV, respectively). Immune hyporesponsiveness was observed in children vaccinated with 23vPPV at 12 months of age compared with chil...

journal_title：Vaccine

authors： Boelsen LK,Dunne EM,Lamb KE,Bright K,Cheung YB,Tikoduadua L,Russell FM,Mulholland EK,Licciardi PV,Satzke C

更新日期：2015-10-13 00:00:00

abstract：:Defective interfering (DI) virus RNAs result from major deletions in full-length viral RNAs that occur spontaneously during de novo RNA synthesis. These RNAs are packaged into virions that are by definition non-infectious, and are delivered to cells normally targeted by the virion. DI RNAs can only replicate with the ...

journal_title：Vaccine

authors： Mann A,Marriott AC,Balasingam S,Lambkin R,Oxford JS,Dimmock NJ

更新日期：2006-05-15 00:00:00

abstract：:We assessed HPV 16 and 18 antibody responses of female subjects enrolled in a 2- vs. 3-dose quadrivalent HPV (Q-HPV) vaccine trial (ClinicalTrials.gov NCT00501137) using the Merck competitive Luminex (cLIA) and total IgG Luminex (TIgG) immunoassays, and a pseudovirus neutralizing antibody (PsV NAb) assay. Subjects wer...

journal_title：Vaccine

authors： Krajden M,Cook D,Yu A,Chow R,Su Q,Mei W,McNeil S,Money D,Dionne M,Palefsky J,Karunakaran K,Kollmann T,Ogilvie G,Petric M,Dobson S

更新日期：2014-01-23 00:00:00

abstract：OBJECTIVE:Evidence-based strategies to address vaccine hesitancy are lacking. Personal values are a measurable psychological construct that could be used to deliver personalized messages to influence vaccine hesitancy and behavior. Our objectives were to develop a valid, reliable self-report survey instrument to measur...

journal_title：Vaccine

authors： Cataldi JR,Sevick C,Pyrzanowski J,Wagner N,Brewer SE,Narwaney KJ,Shoup JA,Resnicow K,Glanz J,Dempsey A,Kwan BM

更新日期：2019-09-10 00:00:00

abstract：:Vibrio cholerae O139 Bengal strain was the causative agent of the recent epidemics of cholera in India and Bangladesh. We studied antibacterial and antitoxin immune responses in acute and convalescent phase paired sera collected from seven of these cholera patients. Significant rise in the levels of both antibacterial...

journal_title：Vaccine

authors： Nandy RK,Albert MJ,Ghose AC

更新日期：1996-08-01 00:00:00

abstract：:Although 80% of HIV infections occur through mucosal routes and vaccine strategies need to be designed for inducing protective immune responses at the site of the viral entry, it has proven to be very challenging to measure these responses. A 2-day workshop was convened by Division of AIDS, National Institutes of Heal...

journal_title：Vaccine

authors： Mehra V,Musib R,Schito ML

更新日期：2010-07-05 00:00:00

abstract：:Recently, an outbreak of fatal infection caused by a pantropic variant (strain CB/05) of canine coronavirus (CCoV) has been reported. In this study, evidence is provided that immunity induced by natural exposure to enteric CCoV is not fully protective against strain CB/05. Twenty-two, 10-week-old beagles with a recent...

journal_title：Vaccine

authors： Decaro N,Elia G,Martella V,Campolo M,Mari V,Desario C,Lucente MS,Lorusso E,Kanellos T,Gibbons RH,Buonavoglia C

更新日期：2010-01-08 00:00:00

abstract：:The immunoscreening of Brugia malayi adult cDNA library with pooled endemic normal sera identified several seroreactive clones including, EC-SOD which contained a 612 bp insert and showed significant nucleotide and deduced amino acid sequence homologies with superoxide dismutase (SOD) of other nematode parasites. The ...

journal_title：Vaccine

authors： Dabir S,Dabir P,Goswami K,Reddy MV

更新日期：2008-07-04 00:00:00

abstract：:To investigate the 1918/19 influenza pandemic daily number of new hospitalizations in the only hospital in Florence (Central Italy) were analyzed. In order to describe the transmission dynamics of the 1918/1919 pandemic influenza a compartmental epidemic model was used. Model simulations show a high level of agreement...

journal_title：Vaccine

authors： Rizzo C,Ajelli M,Merler S,Pugliese A,Barbetta I,Salmaso S,Manfredi P

更新日期：2011-07-22 00:00:00

abstract：BACKGROUND:Influenza vaccination is recommended for immunocompromised patients. METHODS:Children (6 months to 21 years) with cancer, HIV infection, or sickle cell disease (SCD) received 1 or 2 doses of pandemic 2009 H1N1 monovalent influenza vaccine (H1N1 MIV). Safety and tolerability, hemagglutination inhibition (HI)...

journal_title：Vaccine

authors： Hakim H,Allison KJ,Van De Velde LA,Li Y,Flynn PM,McCullers JA

更新日期：2012-01-20 00:00:00

abstract：:Although a highly effective vaccine against smallpox, vaccinia virus (VV) is not without adverse events, some of which can be life-threatening, particularly in immunocompromised individuals. We have recently demonstrated that the immunogenicity and protective efficacy of Dryvax(®) in immunocompetent mice is preserved ...

journal_title：Vaccine

authors： Berhanu A,King DS,Mosier S,Jordan R,Jones KF,Hruby DE,Grosenbach DW

更新日期：2010-12-16 00:00:00