当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Novel Adenovirus type 5 vaccine platform induces cellular immunity against HIV-1 Gag, Pol, Nef despite the presence of Ad5 immunity.

Novel Adenovirus type 5 vaccine platform induces cellular immunity against HIV-1 Gag, Pol, Nef despite the presence of Ad5 immunity.

Abstract：

:Recombinant Adenovirus serotype 5 (Ad5) vectors have been used as vaccine platforms in numerous animal and human clinical studies. The immune response induced by Ad5 vaccines can be mitigated due to pre-existing Ad5 immunity. We previously reported the use of a novel Ad5 platform to induce cellular immune responses (CMI) against HIV-1 Gag in Ad5 hyper immune mice. Here, the effectiveness of the Ad5 [E1-, E2b-] vaccine platform was evaluated using a triad mixture of HIV-1 Gag, Pol, and Nef as antigenic transgenes. Broad CMI was induced following vaccination with the HIV-1 expressing vectors in Ad5 naïve and Ad5 immunized mice. A mixture of the three vaccines induced CMI against each transgene product even in the presence of hyper Ad5 immunity. These studies revealed that CMI responses to immunization with Ad5 [E1-, E2b-]-gag, Ad5 [E1-, E2b-]-pol or Ad5 [E1-, E2b-]-nef vectors were transgene specific and did not induce CMI responses against irrelevant antigens such as carcinoembryonic antigen (CEA), herpes simplex virus glycoprotein B (HSV), cytomegalovirus (CMV) or influenza virus antigens. We are evaluating this recombinant triad viral vector as an HIV-1 vaccine in a non-human primate model and the data indicate that the vaccine is worthy of clinical evaluation.

journal_name

Vaccine

journal_title

Vaccine

authors

Gabitzsch ES,Xu Y,Yoshida LH,Balint J,Amalfitano A,Jones FR

doi

10.1016/j.vaccine.2009.06.028

subject

Has Abstract

pub_date

2009-10-30 00:00:00

pages

6394-8

issue

46

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(09)00862-7

journal_volume

27

pub_type

杂志文章

相关文献

VACCINE文献大全
  • T cells play an essential role in anti-F1 mediated rapid protection against bubonic plague.

    abstract：:Plague, which is initiated by Yersinia pestis infection, is a fatal disease that progresses rapidly and leads to high mortality rates if not treated. Antibiotics are an effective plague therapy, but antibiotic-resistant Y. pestis strains have been reported and therefore alternative countermeasures are needed. In the p...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.07.059

    authors： Levy Y,Flashner Y,Tidhar A,Zauberman A,Aftalion M,Lazar S,Gur D,Shafferman A,Mamroud E

    更新日期：2011-09-16 00:00:00

  • AIDS and HIV vaccines.

    abstract：:In spite of extensive prevention programs, the HIV epidemics is still spreading worldwide, in particularly in developing countries where clade C viruses predominate. WHO estimates that there are 16, 000 new cases of HIV infection daily and that 100 M individuals will be infected by the end of the next decade. In spite...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/s0264-410x(99)00236-4

    authors： Klein M

    更新日期：1999-10-01 00:00:00

  • Expression kinetics of the interleukin-2/immunoglobulin (IL-2/Ig) plasmid cytokine adjuvant.

    abstract：:The development of strategies to augment the immunogenicity of plasmid DNA vaccines is critical for improving their clinical utility. One such strategy involves the coadministration of plasmid cytokine adjuvants with DNA vaccines. Although a large number of plasmid cytokines have shown promise as adjuvants in preclini...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.01.065

    authors： Barouch DH,Truitt DM,Letvin NL

    更新日期：2004-08-13 00:00:00

  • Iscom and iscom-matrix enhance by intranasal route the IgA responses to OVA and rCTB in local and remote mucosal secretions.

    abstract：:Iscoms, with rCTB incorporated via the GM1 receptor, enhanced in mice the mucosal immunogenicity of rCTB as antigen after intranasal (i.n.) administration both by inducing IgA response in the remote intestinal tract mucosa and by a 100-fold increase of the specific IgA locally in the lungs. Iscom-matrix as a separate ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(99)00052-3

    authors： Ekström J,Hu KF,Bengtsson KL,Morein B

    更新日期：1999-06-04 00:00:00

  • The quest for trials on the efficacy of human vaccines. Results of the handsearch of Vaccine.

    abstract：:We report the results of the handsearch of all the issues of Vaccine from 1983 to 1994 to identify randomized and controlled clinical trials (RCTs and CCTs) with the aim of setting up a Cochrane data base of vaccine trials. We read 1119 original papers and located 231 trials of which 117 (50.6%) were RCTs and 114 (49....

    journal_title：Vaccine

    pub_type： 杂志文章,meta分析

    doi：10.1016/0264-410x(95)00247-x

    authors： Jefferson T,Jefferson V

    更新日期：1996-04-01 00:00:00

  • Quantitative determination of C-polysaccharide in Streptococcus pneumoniae capsular polysaccharides by use of high-performance anion-exchange chromatography with pulsed amperometric detection.

    abstract：:Capsular polysaccharides of Streptococcus pneumoniae are used to formulate polyvalent pneumococcal vaccines. A sensitive method, using high-performance anion-exchange chromatography with pulsed amperometric detection (HPAEC-PAD), has been developed to quantify the contamination of pneumococcal capsular polysaccharides...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(00)00535-1

    authors： Talaga P,Bellamy L,Moreau M

    更新日期：2001-04-06 00:00:00

  • Implementation of the Standards for adult immunization practice: A survey of U.S. Health care providers.

    abstract：:The revised Standards for Adult Immunization Practice ("Standards"), published in 2014, recommend routine vaccination assessment, strong provider recommendation, vaccine administration or referral, and documentation of vaccines administered into immunization information systems (IIS). We assessed clinician and pharmac...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.05.073

    authors： Granade CJ,Parker Fiebelkorn A,Black CL,Lutz CS,Srivastav A,Bridges CB,Ball SW,Devlin RG,Cloud AJ,Kim DK

    更新日期：2020-07-14 00:00:00

  • Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines.

    abstract：:Sanaria Inc. has developed methods to manufacture, purify and cryopreserve aseptic Plasmodium falciparum (Pf) sporozoites (SPZ), and is using this platform technology to develop an injectable PfSPZ-based vaccine that provides high-grade, durable protection against infection with Pf malaria. Several candidate vaccines ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2015.09.096

    authors： Richie TL,Billingsley PF,Sim BK,James ER,Chakravarty S,Epstein JE,Lyke KE,Mordmüller B,Alonso P,Duffy PE,Doumbo OK,Sauerwein RW,Tanner M,Abdulla S,Kremsner PG,Seder RA,Hoffman SL

    更新日期：2015-12-22 00:00:00

  • Prevalence and characteristics of HPV vaccine hesitancy among parents of adolescents across the US.

    abstract：BACKGROUND:While many clinicians encounter parents or adolescents who refuse HPV vaccine, little is known about the prevalence of hesitancy for HPV vaccine nationally or its association with vaccination. METHODS:In April 2019, we surveyed families with adolescents 11-17 years using a national online panel (Knowledge P...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.06.074

    authors： Szilagyi PG,Albertin CS,Gurfinkel D,Saville AW,Vangala S,Rice JD,Helmkamp L,Zimet GD,Valderrama R,Breck A,Rand CM,Humiston SG,Kempe A

    更新日期：2020-08-27 00:00:00

  • Does the HIV-1 manipulate immune network via gp120 immunoglobulin-like domain involving V3 loop?

    abstract：:According to the multiple criteria used, the consensus sequences of HIV-1 gp120 and immunoglobulin heavy chain variable segment, which is more than 40 amino acids long, show structural similarities. We assume that this gp120 sequence might encode idiotopes. If this is the case then the particular idiotope-bearing gp12...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(95)98256-a

    authors： Metlas R,Veljković V

    更新日期：1995-03-01 00:00:00

  • Efficient influenza B virus propagation due to deficient interferon-induced antiviral activity in MDCK cells.

    abstract：:Influenza B virus infections are mainly restricted to humans, which is partially caused by the inability of influenza B virus NS1 protein to counteract the innate immune response of other species. However, for cell culture-based influenza vaccine production non-human cells, such as Madin-Darby canine kidney (MDCK) cel...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.05.069

    authors： Frensing T,Seitz C,Heynisch B,Patzina C,Kochs G,Reichl U

    更新日期：2011-09-22 00:00:00

  • Primary in vitro sensitization of human T-helper lymphocytes by peptides derived from the V3 loop of human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein.

    abstract：:To generate CD4+ T-helper cell lines, lymphocytes from HIV-seronegative subjects were primed in vitro with peptides derived from the V3 loop of HIV-1 gp120. Antigen-specific reactivity was inhibited by an anti-DR monoclonal antibody, indicating HLA-class II dependency, but peptides could be recognized in different HLA...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(94)90010-8

    authors： Billaud JN,Yagello M,Gluckman JC

    更新日期：1994-01-01 00:00:00

  • Influenza vaccine effectiveness in preventing influenza-associated intensive care admissions and attenuating severe disease among adults in New Zealand 2012-2015.

    abstract：BACKGROUND:Little is known about inactivated influenza vaccine effectiveness (IVE) in preventing very severe disease, including influenza-associated intensive care unit (ICU) admissions. METHODS:The Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance (SHIVERS) project enrolled adults (age...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.07.028

    authors： Thompson MG,Pierse N,Sue Huang Q,Prasad N,Duque J,Claire Newbern E,Baker MG,Turner N,McArthur C,SHIVERS investigation team.

    更新日期：2018-09-18 00:00:00

  • Expression of Cathepsin S in BCG converts it into a pro-apoptotic and highly immunogenic strain.

    abstract：BACKGROUND:BCG vaccine, introduced almost 100years ago, is the only option to prevent TB disease. It effectively protects newborns from meningeal TB but fails to prevent adult pulmonary TB. TB kills 1.3million people annually in areas where BCG vaccination is widely practiced. Thus, more effective TB vaccines are urgen...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.02.065

    authors： Lau A,Singh V,Soualhine H,Hmama Z

    更新日期：2017-04-11 00:00:00

  • Antigenicity and immunogenicity of unique prefusion-mimic F proteins presented on enveloped virus-like particles.

    abstract：:Pre-fusion stabilizing mutations (DS-Cav1) in soluble fusion (F) proteins of human respiratory syncytial virus (RSV) were previously reported. Here we investigated the antigenic and immunogenic properties of pre-fusion like RSV F proteins on enveloped virus-like particles (VLP). Additional mutations were introduced to...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.09.041

    authors： Kwon YM,Lee Y,Kim KH,Jung YJ,Li Z,Jeeva S,Lee S,Moore ML,Kang SM

    更新日期：2019-10-16 00:00:00

  • Lack of immune interference between inactivated polio vaccine and inactivated rotavirus vaccine co-administered by intramuscular injection in two animal species.

    abstract：:A parenteral inactivated rotavirus vaccine (IRV) in development could address three problems with current live oral rotavirus vaccines (ORV): their lower efficacy in low and middle-income countries (LMICs), lingering concerns about their association with intussusception, and their requirement for a separate supply cha...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.12.043

    authors： Wang Y,Zade J,Moon SS,Weldon W,Pisal SS,Glass RI,Dhere RM,Jiang B

    更新日期：2019-01-29 00:00:00

  • Saponins, IL12 and BCG adjuvant in the FML-vaccine formulation against murine visceral leishmaniasis.

    abstract：:The FML antigen of Leishmania donovani, in combination with either Riedel de Haën (R), QuilA, QS21 saponins, IL12 or BCG, was used in vaccination of an outbred murine model against visceral leishmaniasis (VL). Significant and specific increases in anti-FML IgG and IgM responses were detected for all adjuvants, and in ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(02)00444-9

    authors： Santos WR,de Lima VM,de Souza EP,Bernardo RR,Palatnik M,Palatnik de Sousa CB

    更新日期：2002-11-22 00:00:00

  • Impact of ST-246® on ACAM2000™ smallpox vaccine reactogenicity, immunogenicity, and protective efficacy in immunodeficient mice.

    abstract：:Although a highly effective vaccine against smallpox, vaccinia virus (VV) is not without adverse events, some of which can be life-threatening, particularly in immunocompromised individuals. We have recently demonstrated that the immunogenicity and protective efficacy of Dryvax(®) in immunocompetent mice is preserved ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.10.039

    authors： Berhanu A,King DS,Mosier S,Jordan R,Jones KF,Hruby DE,Grosenbach DW

    更新日期：2010-12-16 00:00:00

  • Measles serological survey in the Italian population: interpretation of results using mixture model.

    abstract：:In 2003-2004, a national measles seroprevalence study was conducted in Italy and data were analysed by using both commercial ELISA cut-off, and by applying a mixture model. Results of the two methods were compared and interpreted in the light of measles incidence, vaccination coverage and previous seroprevalence data....

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.05.094

    authors： Rota MC,Massari M,Gabutti G,Guido M,De Donno A,Ciofi degli Atti ML

    更新日期：2008-08-12 00:00:00

  • Improving immunization data quality in Peru and Mexico: Two case studies highlighting challenges and lessons learned.

    abstract：INTRODUCTION:The Global Vaccine Action Plan and the Regional Immunization Action Plan of the Americas call for countries to improve immunization data quality. Immunization information systems, particularly electronic immunization registries (EIRs), can help to facilitate program management and increase coverage. Howeve...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.10.083

    authors： Trumbo SP,Contreras M,García AGF,Díaz FAE,Gómez M,Carrión V,Ruiz KJP,Aquije R,Danovaro-Holliday MC,Velandia-González M

    更新日期：2018-11-29 00:00:00

  • Meningococcal surrogates of protection--serum bactericidal antibody activity.

    abstract：:Despite the availability of anti-microbial agents effective against Neisseria meningitidis, meningococcal disease continues to be a major global health problem, particularly in the very young. Serogroup A meningococci cause large epidemics in sub-Saharan Africa, whilst serogroups B and C organisms are responsible for ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2005.01.051

    authors： Borrow R,Balmer P,Miller E

    更新日期：2005-03-18 00:00:00

  • Monitoring the process of measles elimination by serosurveillance data: The Apulian 2012 study.

    abstract：:In 2003 Italy adopted the National Plan for Measles and Congenital Rubella Elimination, but some outbreaks of measles are still occurring, as the target coverage rate (≥ 95%) for new-borns has currently not been achieved. In order to support the monitoring of the measles elimination programme, the authors carried out ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.03.011

    authors： Tafuri S,Gallone MS,Gallone MF,Pappagallo MT,Larocca A,Germinario C

    更新日期：2016-04-19 00:00:00

  • Vero-cell rabies vaccine produced using serum-free medium.

    abstract：:A new rabies vaccine was developed from Vero cells adhered to microcarriers, cultivated in a bioreactor in serum-free medium and infected with the PV/VERO-Paris rabies virus strain. The viral suspensions were concentrated by tangential filtration, purified by chromatography and inactivated with beta-propiolactone. In ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.06.014

    authors： Frazatti-Gallina NM,Mourão-Fuches RM,Paoli RL,Silva ML,Miyaki C,Valentini EJ,Raw I,Higashi HG

    更新日期：2004-12-09 00:00:00

  • Naturally-acquired immunity to Neisseria meningitidis group A.

    abstract：:Group A meningococcal disease is epidemic in Sudan, less common in Uganda, a country bordering the "meningitis belt," and rare in North America. The basis of naturally-acquired group A immunity is unknown but in North America protection has been attributed to a high prevalence of serum anticapsular antibodies elicited...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.07.042

    authors： Amir J,Louie L,Granoff DM

    更新日期：2005-01-11 00:00:00

  • Immunogenicity of virus-like particles containing modified human immunodeficiency virus envelope proteins.

    abstract：:Extensive glycosylation and variable loops of the HIV envelope protein (Env) are reported to shield some neutralizing epitopes. Here, we investigated the immunogenicity of mutated HIV Envs presented in virus-like particles (VLPs). We immunized mice with simian human immunodeficiency virus (SHIV) VLPs containing mutant...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.01.107

    authors： Quan FS,Sailaja G,Skountzou I,Huang C,Vzorov A,Compans RW,Kang SM

    更新日期：2007-05-10 00:00:00

  • Seasonal influenza vaccine efficacy and its determinants in children and non-elderly adults: a systematic review with meta-analyses of controlled trials.

    abstract：CONTEXT:The true level of influenza vaccine efficacy is controversial and many factors may influence its estimation. OBJECTIVES:To estimate the efficacy of vaccination of children and non-elderly adults for the prevention of influenza and to explore the impact of type of vaccine, age, degree of strain matching, influe...

    journal_title：Vaccine

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.vaccine.2012.10.084

    authors： DiazGranados CA,Denis M,Plotkin S

    更新日期：2012-12-17 00:00:00

  • Cost-effectiveness of the introduction of two-dose bi-valent (Cervarix) and quadrivalent (Gardasil) HPV vaccination for adolescent girls in Bangladesh.

    abstract：BACKGROUND:Cervical cancer is one of the most prevalent cancers in women caused by the human papillomavirus (HPV) that leads to a substantial disease burden for health systems. Prevention through vaccination can significantly reduce the prevalence of cervical cancer. The objective of this study is to evaluate the poten...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.10.037

    authors： Mahumud RA,Gow J,Alam K,Keramat SA,Hossain MG,Sultana M,Sarker AR,Islam SMS

    更新日期：2020-01-10 00:00:00

  • Assessing the impact of wastage on pediatric vaccine immunization formulary costs using a vaccine selection algorithm.

    abstract：:Pediatric immunization is an important factor in providing protection against numerous common preventable diseases. The success of the pharmaceutical industry in developing new pediatric vaccines has resulted in a crowded recommended immunization schedule requiring several clinic visits over the first 12 years of life...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2003.11.018

    authors： Jacobson SH,Karnani T,Sewell EC

    更新日期：2004-06-02 00:00:00

  • Protection against tetanus toxin in mice nasally immunized with recombinant Lactococcus lactis expressing tetanus toxin fragment C.

    abstract：:Mice inoculated intranasally (i.n.) with a recombinant strain of live Lactococcus lactis expressing tetanus toxin fragment C (TTFC), produced both serum and secretory antibodies to TTFC. Killed bacteria which had accumulated TTFC intracellularly in vitro also elicited protective serum antibody responses. There was no ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(96)00241-1

    authors： Norton PM,Wells JM,Brown HW,Macpherson AM,Le Page RW

    更新日期：1997-04-01 00:00:00

  • Delivering the promise of the Decade of Vaccines: opportunities and challenges in the development of high quality new vaccines.

    abstract：:The Decade of Vaccines (DoV) initiative, launched in 2010, has as its mission "to extend, by 2020 and beyond, the full benefits of immunization to all people, regardless of where they are born, who they are, or where they live". Through their life-saving vaccines, the research-based vaccine companies represented by th...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2012.12.032

    authors： Keith JA,Agostini Bigger L,Arthur PA,Maes E,Daems R

    更新日期：2013-04-18 00:00:00