Hospital-based surveillance and molecular epidemiology of rotavirus infection in Taiwan, 2005-2007.

Abstract:

:To determine the distribution of rotavirus strains and facilitate vaccine policy decisions in Taiwan, active hospital-based gastroenteritis surveillance was conducted in three sentinel hospitals. From 1 January 2005 to 31 December 2007, a total of 3435 children less than 5 years old with gastroenteritis were enrolled. The presence of rotavirus was documented by enzyme immunoassay (EIA), and the G and P genotypes were determined by reverse transcription-polymerase chain reaction (RT-PCR) and sequencing methods. Results confirmed that 856 (25%) of these gastroenteritis admissions were EIA-positive for rotavirus and 448 (52%) of the rotavirus positive admissions were less than 2 years old. The most prevalent rotavirus genotypes were G1P[8] (40%), followed by strains G3P[8] (27%), and G9P[8] (17%). These data will help inform decisions as to whether rotavirus vaccine should be considered for inclusion into Taiwan's National Immunisation Programme.

journal_name

Vaccine

journal_title

Vaccine

authors

Wu FT,Liang SY,Tsao KC,Huang CG,Lin CY,Lin JS,Su CY,Eng HL,Yang JY,Chen PJ,Yang CF

doi

10.1016/j.vaccine.2009.08.090

subject

Has Abstract

pub_date

2009-11-20 00:00:00

pages

F50-4

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(09)01298-5

journal_volume

27 Suppl 5

pub_type

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