A nasal vaccine comprising B-subunit derivative of Shiga toxin 2 for cross-protection against Shiga toxin types 1 and 2.

abstract：:Crimean-Congo hemorrhagic fever virus (CCHFV) poses a great threat to public health due to its high mortality and transmission rate and wide geographical distribution. There is currently no specific antiviral therapy for CCHF. This study provides the first in-depth analysis of the cellular and humoral immune response ...

journal_title：Vaccine

authors： Mousavi-Jazi M,Karlberg H,Papa A,Christova I,Mirazimi A

更新日期：2012-09-28 00:00:00

abstract：:Two cross-sectional population-based telephone surveys interviewed 877 and 1,103 respondents aged >or=65. When compared to the first survey, respondents of the second survey were more likely to have heard of influenza vaccination (IV) (adjusted OR=4.09), to have received IV (adjusted OR=2.04) or to have done so in the...

journal_title：Vaccine

authors： Lau JT,Kim JH,Choi KC,Tsui HY,Yang X

更新日期：2007-11-28 00:00:00

abstract：:To assess the efficacy of the intradermal route of administration of hepatitis A vaccine we conducted a study in hospital laboratory workers. Forty-three volunteers were given three different combinations of intradermal and intramuscular hepatitis A vaccine and compared with 18 controls given intramuscular vaccine onl...

journal_title：Vaccine

authors： Brindle RJ,Morris CA,Berger R,Kurtz JB

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Vaccination against Haemophilus influenzae type b (Hib) is included in routine pediatric immunization schedule in the United States. Previous vaccine shortages have created the need for additional options for Hib vaccination. METHODS:This phase III, randomized, multi-centered study (NCT01000974) evaluated t...

journal_title：Vaccine

authors： Klein NP,Abu-Elyazeed R,Cornish M,Leonardi ML,Weiner LB,Silas PE,Grogg SE,Varman M,Frenck RW,Cheuvart B,Baine Y,Miller JM,Leyssen M,Mesaros N,Roy-Ghanta S

更新日期：2017-06-16 00:00:00

abstract：:Immunologically based fertility control vaccines against zona pellucida (ZP) proteins are being developed in New Zealand for biocontrol of the brushtail possum (Trichosurus vulpecula), an introduced Australian marsupial pest. We have shown that immunization of female possums with recombinant possum ZP3 protein (rZP3) ...

journal_title：Vaccine

authors： Cui X,Duckworth JA,Molinia FC,Cowan PE

更新日期：2010-02-10 00:00:00

abstract：:Estimation of the full disease burden caused by Streptococcus pneumoniae is challenging due to the difficulties in assigning the aetiology especially in lower and upper respiratory infections. We estimated the pneumococcal disease burden by using the vaccine-preventable disease incidence (VPDI) of PHiD-CV10 vaccine (G...

journal_title：Vaccine

authors： Palmu AA,Jokinen J,Nieminen H,Rinta-Kokko H,Ruokokoski E,Puumalainen T,Moreira M,Schuerman L,Borys D,Kilpi TM

更新日期：2018-03-27 00:00:00

abstract：:Pediatric patients with severe chronic kidney disease (CKD) on conservative treatment, on dialysis, and those with renal transplantation are at a higher risk for infectious diseases as the result of impaired immune responses against infectious agents. Infections in these patients can have drastic consequences for dise...

journal_title：Vaccine

authors： Esposito S,Mastrolia MV,Prada E,Pietrasanta C,Principi N

更新日期：2014-11-20 00:00:00

abstract：:We have covalently conjugated an N-terminus Plasmodium vivax apical membrane antigen-1 (AMA-1) peptide to functionalized carbon nanotubes (f-CNT). Immunological characterization of this molecular conjugate revealed that the immunogen-AMA-1 peptide was appropriately presented after being conjugated to CNTs as well as b...

journal_title：Vaccine

authors： Yandar N,Pastorin G,Prato M,Bianco A,Patarroyo ME,Lozano JM

更新日期：2008-10-29 00:00:00

abstract：:Passive immunization of mice with a monoclonal IgE antibody to Schistosoma japonicum (SJ18 epsilon. 1) induces significant protection to a challenge infection and the target molecule of SJ18 epsilon. 1 is paramyosin. In the present study, we demonstrate the B cell epitope of paramyosin recognized by SJ18 epsilon. 1 by...

journal_title：Vaccine

authors： Nara T,Tanabe K,Mahakunkijcharoen Y,Osada Y,Matsumoto N,Kita K,Kojima S

更新日期：1997-01-01 00:00:00

abstract：:Heat killed spores of the Gram-positive bacterium Bacillus subtilis have been evaluated as a vaccine delivery system with mucosal adjuvant properties for influenza. Killed spores were able to bind H5N1 virions (NIBRG-14; clade 1) and, when intra-nasally administered to mice, resulting immune responses, both humoral an...

journal_title：Vaccine

authors： Song M,Hong HA,Huang JM,Colenutt C,Khang DD,Nguyen TV,Park SM,Shim BS,Song HH,Cheon IS,Jang JE,Choi JA,Choi YK,Stadler K,Cutting SM

更新日期：2012-05-09 00:00:00

abstract：:Recombinant Adenovirus serotype 5 (Ad5) vectors have been used as vaccine platforms in numerous animal and human clinical studies. The immune response induced by Ad5 vaccines can be mitigated due to pre-existing Ad5 immunity. We previously reported the use of a novel Ad5 platform to induce cellular immune responses (C...

journal_title：Vaccine

authors： Gabitzsch ES,Xu Y,Yoshida LH,Balint J,Amalfitano A,Jones FR

更新日期：2009-10-30 00:00:00

abstract：:We reviewed studies of rotavirus in MEDLINE and the Chinese literature to get a preliminary estimate of the burden of rotavirus gastroenteritis in China and the epidemiology of the disease. Studies were selected if they were conducted for a period 1 year or more, had more than 100 patients enrolled, and used an accept...

journal_title：Vaccine

authors： Orenstein EW,Fang ZY,Xu J,Liu C,Shen K,Qian Y,Jiang B,Kilgore PE,Glass RI

更新日期：2007-01-05 00:00:00

abstract：:The inflexibility of existing serological techniques for detection of rabies in surveillance constrains the benefit to be gained from many current control strategies. We analysed 304 serum samples from Tanzanian dogs for the detection of rabies antibodies in a pseudotype assay using lentiviral vectors bearing the CVS-...

journal_title：Vaccine

authors： Wright E,McNabb S,Goddard T,Horton DL,Lembo T,Nel LH,Weiss RA,Cleaveland S,Fooks AR

更新日期：2009-11-27 00:00:00

abstract：:Human papillomavirus (HPV) vaccination is now offered to adolescent girls in the UK. Adolescents over 16 years old are likely to make their own decision about the vaccination. The purpose of this cross-sectional study was to assess acceptability of HPV vaccination among female adolescents (16 -- 19 years) and investig...

journal_title：Vaccine

authors： Marlow LA,Waller J,Evans RE,Wardle J

更新日期：2009-04-21 00:00:00

abstract：:Here we confirm that intranasal (IN) dry powder anthrax vaccine formulations are able to protect rabbits against aerosol challenge 9 weeks after a single immunization. The optimum dose of rPA in our dry powder anthrax vaccine formulation in rabbits was experimentally determined to be 150microg and therefore was chosen...

journal_title：Vaccine

authors： Klas SD,Petrie CR,Warwood SJ,Williams MS,Olds CL,Stenz JP,Cheff AM,Hinchcliffe M,Richardson C,Wimer S

更新日期：2008-10-09 00:00:00

abstract：BACKGROUND:23-Valent pneumococcal polysaccharide vaccine, trade name Pneumovax(®)23 (PPSV23), has been used for decades in the Unites States and has an extensive clinical record. However, limited post-licensure safety assessment has been conducted. OBJECTIVE:To analyze reports submitted to the Vaccine Adverse Event Re...

journal_title：Vaccine

authors： Miller ER,Moro PL,Cano M,Lewis P,Bryant-Genevier M,Shimabukuro TT

更新日期：2016-05-27 00:00:00

abstract：:To evaluate the safety and immunogenicity of a diphtheria, tetanus, acellular pertussis and Haemophilus infuenzae Type b (DTaP/Hib) combination vaccine first developed by a Chinese manufacturer, a randomized, two-stage, parallel controlled, single center clinical trial was conducted in Dafeng, Jiangsu Province of Chin...

journal_title：Vaccine

authors： Li G,Zhang H,Zhou W,Ye Q,Li F,Wang H,Hou Q,Xu Y,Ma X,Tan Y,Wang L,Li Y,Li H,Meng F,Liang Q,Liu A,Qin C,Wei W,Liu J,Ruan C,Tao W,Zhang S,Zheng H,Zhu F

更新日期：2010-06-07 00:00:00

abstract：:Seasonal influenza epidemics represent a substantial public health burden, causing significant morbidity and mortality. Influenza in humans can be caused by influenza type A and type B viruses, and although influenza A is responsible for the majority of seasonal influenza infections, influenza B disease is common in c...

journal_title：Vaccine

authors： Belshe RB

更新日期：2010-09-07 00:00:00

abstract：BACKGROUND AND AIMS:Trans-placentally acquired antibodies can protect infants from infection in the first months of life. However, high concentrations of antibody at birth may impact the infant's own immune response to primary immunization. We examine the relationship between concentration of specific antibody to Borde...

journal_title：Vaccine

authors： Jones C,Pollock L,Barnett SM,Battersby A,Kampmann B

更新日期：2014-02-12 00:00:00

abstract：:The World Health Organization, the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, and the Bill & Melinda Gates Foundation convened the first Global Vaccine and Immunization Research Forum (GVIRF) in March 2014. This first GVIRF aimed to track recent progress of the Gl...

journal_title：Vaccine

authors： Ford AQ,Touchette N,Hall BF,Hwang A,Hombach J

更新日期：2016-03-18 00:00:00

abstract：:A recombinant vaccine strain SL3261/pLT105 of attenuated aroA Salmonella enterica serovar Typhimurium SL3261 strain expressing a secreted dengue virus type 2 non-structural NS1 and Yersinia pestis F1 (Caf1) fusion protein, rNS1:Caf1, was generated. Immunological evaluation was performed by prime-boost vaccine regimen....

journal_title：Vaccine

authors： Liu WT,Lin WT,Tsai CC,Chuang CC,Liao CL,Lin HC,Hung YW,Huang SS,Liang CC,Hsu HL,Wang HJ,Liu YT

更新日期：2006-07-26 00:00:00

abstract：:Antibodies against the HIV-1 V1V2 loops were the only correlate of reduced infection risk in the RV144 vaccine trial, highlighting the V1V2 loops as promising targets for vaccine design. The V1V2 loops are structurally plastic, exhibiting either an α-helix-coil or β-strand conformation. V1V2-specific antibodies may th...

journal_title：Vaccine

authors： Lai JI,Eszterhas SK,Brooks SA,Guo C,Zolla-Pazner S,Seaman MS,Bailey-Kellogg C,Griswold KE,Ackerman ME

更新日期：2020-04-16 00:00:00

abstract：:The Indian rhesus macaque is the established animal model for HIV infection and vaccine research. Growing evidence suggests that the more readily available Chinese rhesus macaque may be a more relevant option. As increasing numbers of novel Chinese rhesus MHC alleles are reported, we decided to explore potential HIV v...

journal_title：Vaccine

authors： Liao Q,Strong AJ,Liu Y,Liu Y,Meng P,Fu Y,Touzjian N,Shao Y,Zhao Z,Lu Y

更新日期：2012-02-21 00:00:00

abstract：:It is generally accepted that the introduction of hepatitis B vaccine to national programmes of immunization in developing countries is desirable, but it has so far been constrained by the high cost of the vaccine. To determine the potential minimal costs of the vaccine, a study has been carried out of the production ...

journal_title：Vaccine

authors： Mahoney RT

更新日期：1990-08-01 00:00:00

abstract：:HL1 gene encoding haemolysin from Vibrio harveyi SF-1 was expressed in yeast cells and the expressed haemolysin was displayed on the cell surface. After induction for 36h in galactose-containing medium, one-third of the cells contained the displayed protein and the displayed cells had haemolytic activity on erythrocyt...

journal_title：Vaccine

authors： Zhu K,Chi Z,Li J,Zhang F,Li M,Yasoda HN,Wu L

更新日期：2006-08-28 00:00:00

abstract：:Capsular polysaccharides are important virulence factors of Streptococcus pneumoniae. The polysaccharide has been used as a component of vaccines against pneumococcal diseases either as plain polysaccharide or better conjugated to a protein. The last one is the vaccine of choice to target child protection. The immune ...

journal_title：Vaccine

authors： Chang J,Serrano Y,Garrido R,Rodríguez LM,Pedroso J,Cardoso F,Valdés Y,García D,Fernández-Santana V,Verez-Bencomo V

更新日期：2012-11-19 00:00:00

abstract：:Proteins isolated from the midgut of Glossina pallidipes were used to immunize rabbits and their efficacy as vaccine candidate(s) against the fly, and their potential to block transmission of Trypanosoma brucei rhodesiense assessed. Two fractions, detergent (DET) and aqueous (AQ) fractions were separated using a non-i...

journal_title：Vaccine

authors： Kinyua JK,Nguu EK,Mulaa F,Ndung'u JM

更新日期：2005-05-31 00:00:00

abstract：:Heavy chain fragments of botulinum neurotoxin serotypes A and B are being developed as a bivalent vaccine for botulism. To potentiate the immune response, an aluminum containing adjuvant will be formulated with the two antigens. The adsorption mechanisms of each antigen to aluminum phosphate and aluminum hydroxide adj...

journal_title：Vaccine

authors： DePaz RA,Henderson I,Advant SJ

更新日期：2005-07-01 00:00:00

abstract：:The immunogenicity and protective efficacy of a nucleic acid vaccine encoding the herpes simplex virus type 1 (HSV-1) glycoprotein D (gD) gene under the control of the CMV immediate early gene promoter was examined. Mice immunized three times by intramuscular injection with the vaccine developed an HSV specific IgG bu...

journal_title：Vaccine

authors： Bourne N,Milligan GN,Schleiss MR,Bernstein DI,Stanberry LR

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Timely vaccine supply is critical during influenza pandemics. A recombinant hemagglutinin (rHA)-based vaccine could overcome production hurdles of egg-based vaccines but has never previously been tested in a real-life pandemic setting. The primary aim was to determine the efficacy of a recombinant pandemic v...

journal_title：Vaccine

authors： Gordon DL,Sajkov D,Woodman RJ,Honda-Okubo Y,Cox MM,Heinzel S,Petrovsky N

更新日期：2012-08-03 00:00:00