Abstract:
:Recombinant plasmid DNA constructs expressing truncated or full-length dengue-1 envelope (E) with or without the pre-membrane (prM) were tested for immunogenicity in mice, as candidate dengue DNA vaccines. Two plasmids, one expressing the N-terminal 80% E and the other expressing prM and full length E were immunogenic in intradermally inoculated mice. The vaccinated mice produced dengue-1 specific antibodies that were both neutralizing and long lasting. Data suggested that the plasmid expressing prM and full length E produced virus like particles in transfected cells, and is probably a better immunogen compared to that expressing 80% E.
journal_name
Vaccinejournal_title
Vaccineauthors
Raviprakash K,Kochel TJ,Ewing D,Simmons M,Phillips I,Hayes CG,Porter KRdoi
10.1016/s0264-410x(99)00570-8subject
Has Abstractpub_date
2000-05-08 00:00:00pages
2426-34issue
22eissn
0264-410Xissn
1873-2518pii
S0264-410X(99)00570-8journal_volume
18pub_type
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