Multi-peptide vaccines vialed as peptide mixtures can be stable reagents for use in peptide-based immune therapies.

abstract：:In the present study the efficacy of recombinant plasmids DNA vaccine encoding VP2 gene of very virulent strain of infectious bursal disease virus (vvIBDV) isolated from Pakistan was investigated with or without coadministration of cytocine-phosphate-guanine oligodeoxynucleotide (CpG ODN) to protect the chickens again...

journal_title：Vaccine

authors： Mahmood MS,Siddique M,Hussain I,Khan A,Mansoor MK

更新日期：2006-05-29 00:00:00

abstract：:Effective antigen delivery is one of the most important issues in vaccine development. It has been suggested that adjuvant action results from a depot effect by prolonging the duration of the interaction between antigen and cells, and thus is related to the antigen-releasing properties of emulsion adjuvants. The objec...

journal_title：Vaccine

authors： Yang YW,Wei AC,Shen SS

更新日期：2005-04-08 00:00:00

abstract：:Safety of individuals at risk of immune suppression is an important concern for live vaccines. The new-generation tuberculosis vaccine candidate MTBVAC, a genetically engineered doubly attenuated Mycobacterium tuberculosis mutant with deletions in phoP and fadD26 virulence genes has demonstrated comparable safety in d...

journal_title：Vaccine

authors： Solans L,Uranga S,Aguilo N,Arnal C,Gomez AB,Monzon M,Badiola JJ,Gicquel B,Martin C

更新日期：2014-09-08 00:00:00

abstract：:Live Shigella flexneri 2a and Shigella sonnei Phase I vaccine candidate strains with two virulence-reducing markers were constructed through stepwise incorporation of weakly attenuating purine auxotrophy with subsequent rifampicin-resistance (RNA polymerase) mutation to yield optimal attenuation. These vaccine candida...

journal_title：Vaccine

authors： Linde K,Dentchev V,Bondarenko V,Marinova S,Randhagen B,Bratoyeva M,Tsvetanov Y,Romanova Y

更新日期：1990-02-01 00:00:00

abstract：:A robust vaginal immune response is considered essential for an effective prophylactic vaccine that prevents transmission of HIV and other sexually acquired diseases. Considerable attention has recently focused on the potential of vaginally administered vaccines as a means to induce such local immunity. However, the p...

journal_title：Vaccine

authors： Pattani A,McKay PF,Curran RM,McCaffrey J,Gupta PN,Lowry D,Kett VL,Shattock RJ,McCarthy HO,Malcolm RK

更新日期：2012-04-05 00:00:00

abstract：:There is an emerging interest to develop human vaccines against medically-important fungal pathogens and a need for a preclinical animal model to assess vaccine efficacies and protective correlates. HLA-DR4 (DRB1∗0401 allele) transgenic mice express a human major histocompatibility complex class II (MHC II) receptor i...

journal_title：Vaccine

authors： Hurtgen BJ,Castro-Lopez N,Jiménez-Alzate MDP,Cole GT,Hung CY

更新日期：2016-10-17 00:00:00

abstract：:Vaccine effects of in vivo gene-vaccinated skin graft were evaluated against Toxoplasma gondii (T. gondii) infection. By using a gene gun, cDNA coding T. gondii SAG1 molecule was intracutaneously vaccinated into C57BL/6 (B6; a susceptible strain), BALB/c (a resistant strain) and (C57BL/6 x BALB/c) F1 (CBF1) mice, and ...

journal_title：Vaccine

authors： Saito S,Aosai F,Rikihisa N,Mun HS,Norose K,Chen M,Kuroki T,Asano T,Ochiai T,Hata H,Ichinose M,Yano A

更新日期：2001-02-28 00:00:00

abstract：:To evaluate the usefulness of a DNA vaccine for chickens, we constructed a plasmid vector expressing the Newcastle disease virus F protein (NDV-F) under the control of the human cytomegalovirus immediate early enhancer and chicken beta-actin gene promoter. One-week-old chickens injected intramusculary with the circula...

journal_title：Vaccine

authors： Sakaguchi M,Nakamura H,Sonoda K,Hamada F,Hirai K

更新日期：1996-06-01 00:00:00

abstract：INTRODUCTION:In recent years, vaccine preventable diseases such as measles and pertussis have been re-emerging in Western countries, maybe because of decreasing participation in childhood vaccination programs in some countries. There is clear evidence for vaccine efficacy and the risk of adverse effects is low. This ne...

journal_title：Vaccine

authors： Óskarsson Ý,Guðnason Þ,Jónsdóttir GA,Kristinsson KG,Briem H,Haraldsson Á

更新日期：2015-12-16 00:00:00

abstract：BACKGROUND:Reactions to DTwP vaccine are well known and are a matter of great concern, much for the development of next generation combination vaccines. To avoid such reactions which occur from foreign compounds, WHO suggested manufacture of DTwP vaccine using semi-synthetic medium. The phase III trial reported here wa...

journal_title：Vaccine

authors： Sharma H,Patil V,Sharma D,Kapre S,Jadhav S,Ravetkar S,Kumar R,Bahl S,Parekh S,Chakravarty A

更新日期：2012-09-21 00:00:00

abstract：:General vaccination with the 7-valent pneumococcal conjugate vaccine was recommended in Germany in July 2006 for all children <2 years. The proportion of reported invasive pneumococcal disease (IPD) caused by vaccine serotypes before vaccine introduction was considerably lower than in the US. We report data from natio...

journal_title：Vaccine

authors： Rückinger S,van der Linden M,Reinert RR,von Kries R,Burckhardt F,Siedler A

更新日期：2009-06-24 00:00:00

abstract：:We developed a novel procedure to evoke anti-aggregating beta-amyloid (Abeta) antibodies, using filamentous phages displaying only four amino acids EFRH of the beta-amyloid peptide (AbetaP). This epitope was found to be the main regulatory site for fibril formation. For the first time, effective auto-antibodies have b...

journal_title：Vaccine

authors： Frenkel D,Kariv N,Solomon B

更新日期：2001-03-21 00:00:00

abstract：:The immunogenicity and protective efficacy of a nucleic acid vaccine encoding the herpes simplex virus type 1 (HSV-1) glycoprotein D (gD) gene under the control of the CMV immediate early gene promoter was examined. Mice immunized three times by intramuscular injection with the vaccine developed an HSV specific IgG bu...

journal_title：Vaccine

authors： Bourne N,Milligan GN,Schleiss MR,Bernstein DI,Stanberry LR

更新日期：1996-09-01 00:00:00

abstract：:Vaccines reside in a complex multiscale system that includes biological, clinical, behavioral, social, operational, environmental, and economical relationships. Not accounting for these systems when making decisions about vaccines can result in changes that have little effect rather than solutions, lead to unsustainab...

journal_title：Vaccine

authors： Lee BY,Mueller LE,Tilchin CG

更新日期：2017-01-20 00:00:00

abstract：BACKGROUND:Haemophilus influenzae type b (Hib) conjugate vaccines have significantly limited Hib's disease impact in every country where it was introduced. We previously estimated invasive Hib disease incidence in Singapore at ∼4.4 per 100,000 children <5 years (from 1994 to 2003, period 1), but the vaccine was not inc...

journal_title：Vaccine

authors： Thoon KC,Tee NW,Chew L,Chong CY

更新日期：2014-10-07 00:00:00

abstract：:Due to viral strains, influenza season, and consultations and admission rates varying from country to country, the continued economic evaluation of influenza vaccination for the elderly people aged 65 years and above is paramount, particularly in areas with dense population. Efficacy and cost-effective analysis of inf...

journal_title：Vaccine

authors： Wang ST,Lee LT,Chen LS,Chen TH

更新日期：2005-03-14 00:00:00

abstract：:In Balb/c mice, the sterile protective immunity induced by immunization with radiation-attenuated Plasmodium yoelii sporozoites is eliminated by in vivo depletion of CD8+ T lymphocytes, suggesting that cytotoxic T lymphocytes (CTL) against malaria antigens expressed on infected hepatocytes are required for mediating t...

journal_title：Vaccine

authors： Sedegah M,Chiang CH,Weiss WR,Mellouk S,Cochran MD,Houghten RA,Beaudoin RL,Smith D,Hoffman SL

更新日期：1992-01-01 00:00:00

abstract：:We have examined the efficacy of nucleic acid vaccination in inducing immunity to the multicellular parasite, Schistosoma japonicum, a trematode worm responsible for causing schistosomiasis in humans and other mammalian species. A panel of Schistosoma japonicum cDNAs were cloned into eukaryotic expression vectors, inj...

journal_title：Vaccine

authors： Waine GJ,Yang W,Scott JC,McManus DP,Kalinna BH

更新日期：1997-06-01 00:00:00

abstract：:A gene associated with lipopolysaccharide (LPS) transport was cloned from a local clinical Vibrio cholerae O1 strain of the Ogawa serotype by using the Lactococcus lactis nisin-controlled expression (NICE) system. The V. cholerae wzm gene, which codes for an integral membrane transporter protein, was expressed and tar...

journal_title：Vaccine

authors： Zamri HF,Shamsudin MN,Rahim RA,Neela V

更新日期：2012-05-02 00:00:00

abstract：:Human adenoviruses (AdVs) have been extensively studied as vectors for gene therapy and vaccination. However, little attention has been paid to AdV vaccine development and treatment. Currently, there is a lack of information concerning the immunogenicity of AdV major capsid proteins. Here, using AdV7 as a model, we co...

journal_title：Vaccine

authors： Hu K,Fu M,Guan X,Zhang D,Deng X,Xiao Y,Chen R,Liu H,Hu Q

更新日期：2018-07-05 00:00:00

abstract：:Wildebeest-associated malignant catarrhal fever (WA-MCF), a fatal disease of cattle caused by alcelaphine herpesvirus 1 (AlHV-1), is one of the most important seasonal diseases of cattle in wildebeest endemic areas, with annual incidence reaching 10%. Here we report efficacy of over 80% for a vaccine based on the atte...

journal_title：Vaccine

authors： Cook E,Russell G,Grant D,Mutisya C,Omoto L,Dobson E,Lankester F,Nene V

更新日期：2019-09-20 00:00:00

abstract：:Routine administration of the quadrivalent human papillomavirus (HPV) vaccine has been recommended for 11-12-year-old males since 2011, but coverage remains low. In a U.S. national sample of parents of 11-17-year-old males (n=779), 78.6% of parents reported their sons had not received the HPV vaccine. The most common ...

journal_title：Vaccine

authors： Donahue KL,Stupiansky NW,Alexander AB,Zimet GD

更新日期：2014-06-30 00:00:00

abstract：:Successful launches of recently licensed vaccines contrast with pharmaceutical industry concerns about unfavorable market conditions, making the status and future of vaccine development uncertain. We assessed trends in private-sector vaccine research and development for the period 1995-2008, using a global pharmaceuti...

journal_title：Vaccine

authors： Davis MM,Butchart AT,Coleman MS,Singer DC,Wheeler JR,Pok A,Freed GL

更新日期：2010-02-03 00:00:00

abstract：BACKGROUND:Since the introduction of mumps-containing vaccines (MuCV) in 1995 in Beijing, two-dose MuCV vaccination policy has been used, with the 1st and 2nd doses given at 18 months and 6 years of age, respectively. METHODS:Mumps epidemiology during 2005-2016 was described using surveillance data. Vaccine effectiven...

journal_title：Vaccine

authors： Ma R,Lu L,Zhou T,Pan J,Chen M,Pang X

更新日期：2018-05-03 00:00:00

abstract：:This large study investigates the associations between bovine major histocompatibility complex DRB3 alleles and their binding pockets with the immune response to a 40-mer peptide derived from foot-and-mouth disease virus (FMDV) VP1. A crossbred (Charolais and Holstein) cattle population (n=197) was immunised with the ...

journal_title：Vaccine

authors： Baxter R,Craigmile SC,Haley C,Douglas AJ,Williams JL,Glass EJ

更新日期：2009-12-10 00:00:00

abstract：:Potent liposomal PorA formulations containing various lipopolysaccharide (LPS) derivatives were developed. The following adjuvants were compared: the commonly used aluminum phosphate (AlPO(4)), and three LPS like adjuvants: monophosphoryl lipid A (MPL), lipopolysaccharide (galE LPS) and the less toxic LPS mutant lpxL1...

journal_title：Vaccine

authors： Arigita C,Luijkx T,Jiskoot W,Poelen M,Hennink WE,Crommelin DJ,Ley Pv,Els Cv,Kersten GF

更新日期：2005-10-17 00:00:00

abstract：:The objective of this paper is to review adaptive immunity of young animals using examples from my own experience and from the literature. Trials carried out by us with a modified live and inactivated canine parvovirus vaccine in newborn puppies provide evidence of the immune capacity of these puppies. With regard to ...

journal_title：Vaccine

authors： Chappuis G

更新日期：1998-08-01 00:00:00

abstract：:The cost-effectiveness of different mass dog rabies vaccination strategies, defined as the costs per year of life lost (YLL) averted was evaluated for a period of 10 years by means of a dynamic simulation study for a typical village on Flores Island. In the base strategy (no dog vaccination and no post-exposure treatm...

journal_title：Vaccine

authors： Wera E,Mourits MCM,Hogeveen H

更新日期：2017-12-04 00:00:00

abstract：:During a pertussis epidemic in 2011-2012 the Western Australian (WA) Department of Health implemented a 'cocooning' programme, offering free pertussis-containing vaccine (dTpa) to new parents. We assessed the impact of vaccinating parents with dTpa on the incidence of pertussis infection in newborns. Births in WA duri...

journal_title：Vaccine

authors： Carcione D,Regan AK,Tracey L,Mak DB,Gibbs R,Dowse GK,Bulsara M,Effler PV

更新日期：2015-10-13 00:00:00

abstract：OBJECTIVES:The objective of this study was to evaluate the impact of introduction of 9vHPV vaccine on HPV vaccination uptake (doses per capita) and initiation (≥1 doses), completion (≥3 doses) and compliance (≥3 doses within 12 months) by adolescents. METHODS:We used a retrospective cohort analysis using North Carolin...

journal_title：Vaccine

authors： Trogdon JG,Shafer P,Lindsay B,Coyne-Beasley T

更新日期：2018-02-28 00:00:00