Abstract:
:To evaluate the usefulness of a DNA vaccine for chickens, we constructed a plasmid vector expressing the Newcastle disease virus F protein (NDV-F) under the control of the human cytomegalovirus immediate early enhancer and chicken beta-actin gene promoter. One-week-old chickens injected intramusculary with the circular plasmid DNA did not produce significant levels of antibody against NDV-F. However, two of five birds injected with the linearized plasmid DNA produced high levels of the antibody. Moreover, four of five birds injected with a mixture of the linearized-plasmid and Lipofectin produced the antibody efficiently. At 9 weeks post-injection, chickens were challenged with the velogenic NDV Sato strain. These chickens that had the antibody against NDV-F were protected from lethal NDV challenge. These results demonstrate that the DNA vaccine conferred efficient protection against the disease.
journal_name
Vaccinejournal_title
Vaccineauthors
Sakaguchi M,Nakamura H,Sonoda K,Hamada F,Hirai Kdoi
10.1016/0264-410x(95)00254-xsubject
Has Abstractpub_date
1996-06-01 00:00:00pages
747-52issue
8eissn
0264-410Xissn
1873-2518pii
0264410X9500254Xjournal_volume
14pub_type
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