Abstract：
:Respiratory syncytial virus (RSV) infection is the single most important cause of serious acute respiratory illness in children <1 year of age worldwide, and is associated with life-threatening pneumonia or bronchiolitis in the elderly. Current vaccine strategies include live, attenuated virus, subunit and DNA vaccines, however, none have been sufficiently safe, or shown to induce satisfactory long-term immunity, thus immune modulators are being considered to enhance the effectiveness of RSV vaccines. In this study, we examine CD40 ligand (CD40L) as an immune modulator to enhance the durability of DNA vaccines encoding RSV F and/or G glycoproteins in BALB/c mice. The addition of CD40L to DNA vaccines encoding the F glycoprotein enhanced virus clearance and some aspects of the immune response to RSV challenge, suggesting that CD40L may enhance the durability of RSV DNA vaccines.
journal_name
Vaccinejournal_title
Vaccineauthors
Harcourt JL,Brown MP,Anderson LJ,Tripp RAdoi
10.1016/s0264-410x(03)00119-1subject
Has Abstractpub_date
2003-06-20 00:00:00pages
2964-79issue
21-22eissn
0264-410Xissn
1873-2518pii
S0264410X03001191journal_volume
21pub_type
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