Abstract：
:We developed a novel procedure to evoke anti-aggregating beta-amyloid (Abeta) antibodies, using filamentous phages displaying only four amino acids EFRH of the beta-amyloid peptide (AbetaP). This epitope was found to be the main regulatory site for fibril formation. For the first time, effective auto-antibodies have been obtained in guinea-pigs, which exhibit human identity in the AbetaP. Immunization through a phage-carrying epitope was found to be long-lasting, and no toxic effect caused by autoimmune response was detected in the challenged animal sections. These antibodies performed similarly to site-directed monoclonal antibodies and to antibodies raised against fibrillar Abeta in disaggregation of plaques, and may serve as the basis for developing an anti-Abeta vaccine.
journal_name
Vaccinejournal_title
Vaccineauthors
Frenkel D,Kariv N,Solomon Bdoi
10.1016/s0264-410x(00)00501-6subject
Has Abstractpub_date
2001-03-21 00:00:00pages
2615-9issue
17-19eissn
0264-410Xissn
1873-2518pii
S0264410X00005016journal_volume
19pub_type
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