Abstract：
AIM:To investigate parents' views regarding potential new vaccines. We examined attitudes towards severity of specific infections, acceptability of potential vaccines and preferences for the number of injections they would want their child to receive on any one occasion. DESIGN:Cross sectional survey. METHODS:Parents of children aged 18-24 months in three Primary Care Trusts in England were asked to complete a questionnaire. RESULTS:Of the 859 parents who responded (38%), over 90% believed that the vaccines currently on offer prevent disease always or almost always. Of those who rated meningitis as serious or very serious, 84% would accept a vaccine against meningococcal group B infection and 69% against pneumococcal infection. Only 34% of those who said their child would make a full recovery from chicken pox would accept a vaccine. Over half the respondents preferred new vaccines to be given separately. Fifty seven percent of parents would not want their child to have more than two injections per clinic visit. CONCLUSIONS:Parents' views on the severity of illness influence their acceptance of a new vaccine. Their preference for as few injections as possible at a single clinic visit needs to be reconciled with their concerns over the use of combination vaccines.
journal_name
Vaccinejournal_title
Vaccineauthors
Bedford H,Lansley Mdoi
10.1016/j.vaccine.2007.08.057subject
Has Abstractpub_date
2007-11-07 00:00:00pages
7818-23issue
45eissn
0264-410Xissn
1873-2518pii
S0264-410X(07)00972-3journal_volume
25pub_type
杂志文章相关文献
VACCINE文献大全abstract：:Human chorionic gonadotropin (hCG) is currently under investigation as an antigenic target in both anti-cancer and anti-fertility vaccines. Formulations studied to date show promise in clinical trials for both applications yet are expensive to produce and require frequented administration in order to maintain an effec...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(96)00046-1
更新日期：1996-11-01 00:00:00
abstract：:Feline immunodeficiency virus (FIV) is a natural lentiviral pathogen of cats which can be experimentally transmitted via rectal and vaginal routes--the major routes of human immunodeficiency virus type 1 transmission in man. An important objective for lentiviral research is the development of vaccine strategies which ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(00)00131-6
更新日期：2000-08-01 00:00:00
abstract：:To identify predictive factors of complete and age-appropriate vaccination status in Greece, we conducted a cross-sectional study, using stratified cluster sampling, among children attending the first year of the Greek Grammar school (about 6 years of age) and their parents/guardians. Almost 88% (N=3878) of pupils in ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.11.078
更新日期：2010-02-17 00:00:00
abstract：:Across the developing world peste des petits ruminants virus places a huge disease burden on agriculture, primarily affecting the production of small ruminant. The disease is most effectively controlled by vaccinating sheep and goats with live attenuated vaccines that provide lifelong immunity. However, the current va...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.10.050
更新日期：2015-01-09 00:00:00
abstract：:ISCOMATRIX adjuvant is capable of inducing broad and potent humoral and cellular immune responses. The components are well defined and the manufacturing process is simple and robust. Many vaccines containing the ISCOMATRIX adjuvant have been tested in a range of animal models, including human and non-human primates. S...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2003.12.031
更新日期：2004-06-23 00:00:00
abstract：:Pertussis vaccination in pregnancy has been introduced by several national advisory bodies, mostly in industrialized countries, as a means to protect young infants from disease by high titers of maternal antibodies. Most recommendations derive from epidemiological needs, but many knowledge gaps remained after implemen...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2017.03.061
更新日期：2017-08-16 00:00:00
abstract：:Schmallenberg virus (SBV), which emerged in 2011 in Central Europe and subsequently spread very rapidly throughout the continent, affects predominantly ruminants. SBV is transmitted by insect vectors, and therefore vaccination is one of the major tools of disease control. Only recently, a domain connected to virus neu...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.07.047
更新日期：2018-08-16 00:00:00
abstract：:Ricin is a plant toxin that is a CDC level B biothreat. Our recombinant ricin A chain vaccine (RiVax), which contains mutations in both known toxic sites, has no residual toxicity at doses at least 800 times the immunogenic dose. RiVax without adjuvant given intramuscularly (i.m.) protected mice against intraperitonea...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.08.018
更新日期：2007-10-16 00:00:00
abstract：:The development of a safe and effective vaccine against enterotoxigenic Escherichia coli (ETEC) would be useful for travellers and for young children in endemic areas. A feasibility study of an enteral ETEC vaccine prototype consisting of colonization factor antigen II (CFA/II), containing two component antigens CS1 a...
journal_title：Vaccine
pub_type： 临床试验,杂志文章
doi：10.1016/s0264-410x(94)80038-2
更新日期：1994-11-01 00:00:00
abstract：:Pertussis has re-emerged as a public health problem in Canada in recent years, emphasizing concerns about the effectiveness of the currently licensed whole-cell vaccine. Following a 1994 outbreak in Nova Scotia, we conducted a case-control study of 483 children aged < 10 years to assess vaccine effectiveness. Ninety-t...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(96)00176-4
更新日期：1997-02-01 00:00:00
abstract：:The induction of oral tolerance against disease-inducing antigens has emerged as a feasible strategy to prevent immunopathologies. In this study, we investigated the effect of oral immunization with whole antigens of Leishmania amazonensis promastigotes (LaAg) on murine cutaneous leishmaniasis. We found that two oral ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(03)00427-4
更新日期：2003-09-08 00:00:00
abstract：:The adenylate cyclase (CyaA) produced by Bordetella pertussis is able to deliver CD8+ and CD4+ T-cell epitopes genetically grafted within the catalytic domain of the molecule into antigen presenting cells in vivo. We develop now a new approach in which peptides containing CD8+ epitopes are chemically linked to CyaA. W...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2004.07.018
更新日期：2004-12-16 00:00:00
abstract：:Malaria represents a major global health problem but despite extensive efforts, no effective vaccine is available. Various vaccine candidates have been developed that provide protection in animal models, such as a gene gun-delivered DNA vaccine encoding the circumsporozoite protein (CSP) of Plasmodium berghei. A commo...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.06.059
更新日期：2009-09-18 00:00:00
abstract：BACKGROUND:Data on duration of protection against invasive meningococcal disease post-vaccination with the recombinant, 4-component, meningococcal serogroup B vaccine (4CMenB) are limited. We evaluated bactericidal activity persistence in adolescents/young adults up to 7.5 years post-primary vaccination with 4CMenB, an...
journal_title：Vaccine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.vaccine.2018.12.059
更新日期：2019-02-21 00:00:00
abstract：:Neisseria meningitidis is an important cause of bacterial meningitis and septicaemia with most disease caused by meningococci bearing serogroups A, B, C, Y and W-135 polysaccharides. Monovalent serogroup C conjugate vaccines have become established in the immunisation programmes in many countries and the first quadriv...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2009.05.003
更新日期：2009-06-24 00:00:00
abstract：:The live bacterial vaccine Mycobacterium bovis BCG (BCG) is a vehicle worth noticing for various protective antigens. The gene encoding the B-cell epitope of the oligopeptide repeating in the circumsporozoite protein (C.S. protein) of the rodent malaria parasite, Plasmodium yoelii, was inserted into the plasmid vector...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(95)00131-j
更新日期：1996-01-01 00:00:00
abstract：:As measured by fluid accumulation in ileal loops, Vibrio cholerae mucinase complex, with or without toxoid, protected guinea pigs from challenges with V. cholerae live organisms and enterotoxin. The neuraminidase and proteinases of the complex were combined in modified oil emulsion or aluminum hydroxide adjuvants and ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2003.12.004
更新日期：2004-06-02 00:00:00
abstract：:Mycoplasma hyopneumoniae (M. hyopneumoniae) vaccine strain 168 is an intrapulmonically injected attenuated live vaccine that is available in the Chinese market. The aim of this study was to develop suitable adjuvants for this live vaccine to provide effective protection after intramuscular inoculation. Several adjuvan...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.03.071
更新日期：2014-06-05 00:00:00
abstract：BACKGROUND:Despite being committed to the immunization agenda set by the WHO, Italy is currently experiencing decreasing vaccination rates and increasing incidence of vaccine-preventable diseases. Our aim is to analyze Italian online debates on pediatric immunizations through a content analytic approach in order to qua...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.11.007
更新日期：2015-12-16 00:00:00
abstract：BACKGROUND:MenB-4C (Bexsero®) is a multicomponent serogroup B meningococcal vaccine. For vaccine licensure, efficacy was inferred from serum bactericidal antibody (SBA) against three antigen-specific indicator strains. The bactericidal role of antibody to the fourth vaccine antigen, Neisserial Heparin binding antigen (...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.06.020
更新日期：2017-07-24 00:00:00
abstract：:Current available influenza vaccines are safe and effective in preventing influenza. Nevertheless, there is a need for influenza vaccines with improved efficacy in the elderly. This need is underscored by both the observation that influenza has a major clinical and economic impact in the elderly and the fact that curr...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.vaccine.2005.04.020
更新日期：2005-07-08 00:00:00
abstract：BACKGROUND:The hepatitis A (HepA) vaccine was recommended by the Advisory Committee on Immunization Practices (ACIP) incrementally from 1996 to 1999. In 2006, HepA vaccine was recommended (1) universally for children aged 12-23 months, (2) for persons who are at increased risk for infection, or (3) for any person wishi...
journal_title：Vaccine
pub_type： 历史文章,杂志文章
doi：10.1016/j.vaccine.2018.01.090
更新日期：2018-03-14 00:00:00
abstract：:Immune responses to poorly immunogenic antigens, such as polysaccharides, can be enhanced by conjugation to carriers. Our previous studies indicate that conjugation to Vi polysaccharide of Salmonella Typhi may also enhance immunogenicity of some protein carriers. We therefore explored the possibility of generating a b...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.04.035
更新日期：2018-05-17 00:00:00
abstract：:Six adjuvant formulations were compared for their ability to potentiate the primary and memory antibody responses in mice to three companion animal vaccine immunogens--feline leukemia virus (FeLV), feline immunodeficiency virus (FIV), and a recombinantly-derived heartworm antigen. The combination of a novel bacterial ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(97)00136-9
更新日期：1997-12-01 00:00:00
abstract：:Ten adult volunteers, with low prevaccination levels of serum IgG antibodies against meningococcal antigens (< 1 microg ml(-1)), received three doses of the Norwegian group B meningococcal outer membrane vesicle (OMV) vaccine intramuscularly at weeks 0, 6 and 46. Anti-OMV IgG subclass responses were measured and compa...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(98)00259-x
更新日期：1999-02-26 00:00:00
abstract：:In a previous work we selected montanide ISA720 (M-ISA720) among different adjuvants for the vaccination with a V3 loop based multi-epitope polypeptide TAB9. In this paper we present the evaluation of the toxicity and immunogenicity of this formulation in non-human primates. TAB9 in M-ISA720 was highly immunogenic in ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(98)00358-2
更新日期：1999-05-04 00:00:00
abstract：:To inform World Health Organization recommendations regarding use of Haemophilus influenzae type b (Hib) vaccines in national immunization programs, a multi-country evaluation of trends in Hib meningitis incidence and prevalence of nasopharyngeal Hib carriage was conducted in four South American countries using either...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.10.101
更新日期：2012-01-05 00:00:00
abstract：BACKGROUND:Immunization programs' resilience to shocks is central to their success, but little empirical evidence documents resilience in action. We sought to characterize the decline of HPV vaccination in Denmark after negative media coverage and recovery during a national information campaign. METHODS:We conducted a...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2019.12.019
更新日期：2020-02-11 00:00:00
abstract：:Active and passive immunotherapy targeting amyloid-β (Aβ) may be the most promising strategy to prevent or treat Alzheimer's disease (AD). Previously, immunization with the recombinant 6Aβ15-T antigen generated robust anti-Aβ serum antibodies that strongly recognized Aβ42 oligomers in different mice, markedly reduced ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2016.02.056
更新日期：2016-04-04 00:00:00
abstract：BACKGROUND:Although the mortality from diarrheal diseases has been decreasing dramatically in Iran, it still represents an important proportion of disease burden in children <5 years old. Rotavirus vaccines are among the most effective strategies against diarrheal diseases in specific epidemiological conditions. This s...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.12.035
更新日期：2015-05-07 00:00:00
