Rectal immunization of mice with hepatitis A vaccine induces stronger systemic and local immune responses than parenteral immunization.

abstract：:In this study, we tested the hypothesis that adoptive transfer of dendritic cells (DCs) transfected ex vivo with mRNA encoding hepatitis C virus (HCV) NS3/4A would initiate potent HCV-specific protective immune responses in vivo. Murine DCs were transfected with NS3/4A mRNA or eGFP mRNA using either electroporation or...

journal_title：Vaccine

authors： Yu H,Babiuk LA,van Drunen Littel-van den Hurk S

更新日期：2007-02-26 00:00:00

abstract：:The co-administration of the tetravalent meningococcal conjugate vaccine, MenACWY-TT, with a licensed hepatitis A and B vaccine, HepA/B (Twinrix(®)), was compared to their separate administration in this open, randomised, controlled study. Healthy subjects 11-17 years of age (n=611) were randomised (3:1:1) to receive ...

journal_title：Vaccine

authors： Østergaard L,Silfverdal SA,Berglund J,Flodmark CE,West C,Bianco V,Baine Y,Miller JM

更新日期：2012-01-17 00:00:00

abstract：:Oral administration of antigen is known to be appropriate for some vaccine purposes as well as oral tolerance induction. In the present study, oral administration of beta-lactoglobulin (BLG) loaded poly(D,L-lactide-co-glycolide) (D,L-PLG) microspheres induced tolerance was evaluated. A single feeding of 5 micrograms o...

journal_title：Vaccine

authors： Pecquet S,Leo E,Fritsché R,Pfeifer A,Couvreur P,Fattal E

更新日期：2000-01-18 00:00:00

abstract：:Positive clone Hq05 of Haemaphysalis qinghaiensis (named following those cDNA clones cloned from the tick before) was obtained by differentially screening of a cDNA library of the tick with rabbit anti-tick salivary gland serum and rabbit anti-tick saliva serum. Hq05 contains an open reading frame (ORF) of 540bp that ...

journal_title：Vaccine

authors： Gao J,Luo J,Fan R,Schulte-Spechtel UC,Fingerle V,Guan G,Zhao H,Li Y,Ren Q,Ma M,Liu Z,Liu A,Dang Z,Sugimoto C,Yin H

更新日期：2009-01-14 00:00:00

abstract：:Pertussis is an acute respiratory infectious disease caused by the bacterium Bordetella pertussis. Although pertussis vaccination was introduced in the 1960s, pertussis is still an endemic disease in China. To better understand the genetic diversity of the Chinese B. pertussis population, we characterized 115 clinical...

journal_title：Vaccine

authors： Xu Y,Zhang L,Tan Y,Wang L,Zhang S,Wang J

更新日期：2015-11-17 00:00:00

abstract：:As the clinical experience with cancer vaccines and cancer immunotherapy increases, there are important lessons that can be learned from the successes and failures of past trials. Many lessons affect the design and conduct of clinical trials themselves. Appropriate patient selection, clinical trial design, immunologic...

journal_title：Vaccine

authors： Clifton GT,Kohrt HE,Peoples GE

更新日期：2015-12-16 00:00:00

abstract：BACKGROUND:Mycobacterial infections greatly affect human and animal health worldwide, and vaccines are effective, sustainable and economic interventions for the prevention and control of these infectious diseases. Recent results support the use of zebrafish as a model for studying the pathophysiology of mycobacterial i...

journal_title：Vaccine

authors： Risalde MA,López V,Contreras M,Mateos-Hernández L,Gortázar C,de la Fuente J

更新日期：2018-07-16 00:00:00

abstract：BACKGROUND:Roughly half of U.S. adults do not receive recommended booster vaccinations, but protective antibody levels are rarely measured in adults. Demographic factors, vaccination history, and responses to other vaccinations could help identify at-risk individuals. We sought to characterize rates of seroconversion a...

journal_title：Vaccine

authors： Garman L,Vineyard AJ,Crowe SR,Harley JB,Spooner CE,Collins LC,Nelson MR,Engler RJ,James JA

更新日期：2014-09-29 00:00:00

abstract：:The aim of this study was to investigate whether, the vaccine Priorix causes less immediate injection pain than MMR-II in vaccination of infants aged 18-24 months who were offered vaccine against measles, mumps and rubella. The infants were randomised into one of the two vaccine groups (Priorix/MMR-II in a double-blin...

journal_title：Vaccine

authors： Knutsson N,Jansson UB,Alm B

更新日期：2006-07-26 00:00:00

abstract：:Orally delivered replicating adenovirus (Ad) vaccines have been used for decades to prevent adenovirus serotype 4 and 7 respiratory illness in military recruits, demonstrating exemplary safety and high efficacy. That experience suggests that oral administration of live recombinant Ads (rAds) holds promise for immuniza...

journal_title：Vaccine

authors： Deal C,Pekosz A,Ketner G

更新日期：2013-07-11 00:00:00

abstract：:The aim of this work was to evaluate the microencapsulation by spray-drying of inactivated Vibrio cholerae, using methacrylic copolymers Eudragit® L30D-55 and FS30D. The microparticles obtained presented a particle size around 3.0 μm. The preparation temperature affected the morphology and the antigenicity of micropar...

journal_title：Vaccine

authors： Año G,Esquisabel A,Pastor M,Talavera A,Cedré B,Fernández S,Sifontes S,Aranguren Y,Falero G,García L,Solís RL,Pedraz JL

更新日期：2011-08-05 00:00:00

abstract：:The innocuousness of the Brucella melitensis Rev 1 live attenuated vaccine strain has never been fully assessed in rams. The immunopathological responses and the kinetics and distribution of the infection induced by this strain were determined after subcutaneous or conjunctival vaccination in both young (3-4 months ol...

journal_title：Vaccine

authors： Muñoz PM,de Miguel MJ,Grilló MJ,Marín CM,Barberán M,Blasco JM

更新日期：2008-05-19 00:00:00

abstract：:A passive immunity test (MPT) in suckling mice for the quantification of protective anti-foot-and-mouth disease virus (FMDV) antibodies in serum is described. Comparisons with titres obtained using conventional serum neutralization tests show that for cattle given synthetic peptide vaccines this in vivo assay is a bet...

journal_title：Vaccine

authors： Mulcahy G,Pullen LA,Gale C,DiMarchi RD,Doel TR

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Following primary vaccination of adults ⩾65years of age with 23-valent pneumococcal polysaccharide vaccine (PPSV23), immune responses increase and thereafter appear to decrease over time. With increased life expectancy worldwide, revaccination with PPSV23 may be required for continued protection of the elder...

journal_title：Vaccine

authors： Kawakami K,Kishino H,Kanazu S,Toshimizu N,Takahashi K,Sterling T,Wang M,Musey L

更新日期：2016-07-19 00:00:00

abstract：:Household surveys are frequently used as means of vaccination coverage measurement, but obtaining accurate survey estimates present several challenges. In 2015, the World Health Organization (WHO) released a working draft of its updated Vaccination Coverage Survey Reference Manual that moved well beyond the traditiona...

journal_title：Vaccine

authors： Danovaro-Holliday MC,Dansereau E,Rhoda DA,Brown DW,Cutts FT,Gacic-Dobo M

更新日期：2018-08-16 00:00:00

abstract：:Oral polio vaccine (OPV) and diphtheria-tetanus-pertussis (DTP) vaccines are given simultaneously in routine immunisation programmes in developing countries. It is therefore difficult to determine the separate effects of these vaccines on survival. We used the shortage of DTP vaccine in Bissau to examine the impact of...

journal_title：Vaccine

authors： Aaby P,Rodrigues A,Biai S,Martins C,Veirum JE,Benn CS,Jensen H

更新日期：2004-08-13 00:00:00

abstract：:Since 2000, there has been a legal requirement in the UK that dogs and cats should have an effective rabies vaccination with demonstrable sero-conversion if their owners wish to avoid quarantine on re-entry to the UK. In 2002, 10,483 rabies titres were determined on dogs at the VLA. Statistical analyses assessed the e...

journal_title：Vaccine

authors： Kennedy LJ,Lunt M,Barnes A,McElhinney L,Fooks AR,Baxter DN,Ollier WE

更新日期：2007-12-12 00:00:00

abstract：:In the United States, co-administration of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine and tetravalent meningococcal conjugate vaccine (MCV4) is recommended in adolescents. In this clinical study, 1341 adolescents received Tdap (Boostrix® GlaxoSmithKline) and MCV4 (Menactra®, Sanof...

journal_title：Vaccine

authors： Weston WM,Friedland LR,Wu X,Howe B

更新日期：2011-01-29 00:00:00

abstract：:Vaccines reside in a complex multiscale system that includes biological, clinical, behavioral, social, operational, environmental, and economical relationships. Not accounting for these systems when making decisions about vaccines can result in changes that have little effect rather than solutions, lead to unsustainab...

journal_title：Vaccine

authors： Lee BY,Mueller LE,Tilchin CG

更新日期：2017-01-20 00:00:00

abstract：:M2 is the third integral membrane protein of influenza A. M2e, the extracellular, 23 amino acid residues of M2, has been remarkably conserved in all human influenza A strains. This prompted us to evaluate the use of M2e as a potential broad-spectrum immunogen in a mouse model for influenza infection. Genetic fusion of...

journal_title：Vaccine

authors： De Filette M,Fiers W,Martens W,Birkett A,Ramne A,Löwenadler B,Lycke N,Jou WM,Saelens X

更新日期：2006-11-10 00:00:00

abstract：:Salmonella Enteritidis mutants with deletions in phoP, fliC or phoPfliC were tested for their virulence and their ability to induce parameters of the innate and adaptive immunity in addition to their potential for serological differentiation between vaccinated, non-vaccinated and infected chickens. The double phoPfliC...

journal_title：Vaccine

authors： Methner U,Barrow PA,Berndt A,Rychlik I

更新日期：2011-04-12 00:00:00

abstract：:Active surveillance was conducted by the 12 centers of the Canadian Immunization Monitoring Program, Active from 2000-2007 in children 16 years of age and younger to determine the influence of 7-valent pneumococcal conjugate immunization programs on the prevalence, serotype and antibiotic resistance patterns of invasi...

journal_title：Vaccine

authors： Bettinger JA,Scheifele DW,Kellner JD,Halperin SA,Vaudry W,Law B,Tyrrell G,Canadian Immunization Monitoring Program, Active (IMPACT).

更新日期：2010-02-25 00:00:00

abstract：BACKGROUND:Invasive meningococcal disease has a high burden in young children, particularly during infancy. We investigated the immunogenicity and safety of a quadrivalent meningococcal conjugated vaccine (MenACWY-TT) co-administered with routine vaccines in healthy infants. METHODS:In this phase IIIb study (NCT013408...

journal_title：Vaccine

authors： Dbaibo G,Tinoco Favila JC,Traskine M,Jastorff A,Van der Wielen M

更新日期：2018-06-27 00:00:00

abstract：:DNA isolates from a number of established cell lines have been tested for their transforming capacity in the NIH3T3 transformation assay. It has been found that this assay can be used to quantify the amount of transforming DNA at a submicrogram to milligram level. This assay system has been applied to validate the red...

journal_title：Vaccine

authors： van Meel FC,Steenbakkers PG,Bos E

更新日期：1985-12-01 00:00:00

abstract：:Feline panleukopenia virus (FPV) is an important infectious pathogen of all members of the family Felidae. Here, we describe construction of a replication-competent recombinant canine adenovirus type 2 (CAV-2) expressing the VP2 protein of FPV (CAV-2-VP2) by transfection of MDCK cells with recombinant CAV-2 genome car...

journal_title：Vaccine

authors： Yang S,Xia X,Qiao J,Liu Q,Chang S,Xie Z,Ju H,Zou X,Gao Y

更新日期：2008-03-10 00:00:00

abstract：:Although vaccination against Streptococcus pneumoniae (S. pneumoniae) and Haemophilus influenzae type b (Hib) is recommended for immunocompromised patients, such as patients with B-cell chronic lymphocytic leukaemia (B-CLL), its protective effect is questionable. We studied antibody responses to pneumococcal polysacch...

journal_title：Vaccine

authors： Hartkamp A,Mulder AH,Rijkers GT,van Velzen-Blad H,Biesma DH

更新日期：2001-02-08 00:00:00

abstract：:SOCS1-1 is crucial for control of immune cell cytokine expression, including those cytokines known to enable memory T-cell formation and homeostasis. In this study, we found that immunization with SOCS1-downregulated bone marrow-derived dendritic cells generated increased antigen-specific CD8(+) T memory cells and ant...

journal_title：Vaccine

authors： Aldrich M,Sanders D,Lapteva N,Huang XF,Chen SY

更新日期：2008-02-20 00:00:00

abstract：:From 1983 to 1993 two anti-hepatitis B vaccinal strategies were adopted in two small towns of Southern Italy at high incidence for HBV infections: Afragola (prevalence of HBsAg carriers of 13.4%) and Frattamaggiore (prevalence of HBsAg carriers of 12.9%). In Afragola, the universal vaccination of infants in their firs...

journal_title：Vaccine

authors： Da Villa G,Picciottoc L,Elia S,Peluso F,Montanaro F,Maisto T

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Parents' attitudes toward MMR vaccine and measles, mumps and rubella infections relate to their child's MMR status, therefore improving these attitudes is central to improving current suboptimal MMR uptake. However, no study has yet combined evidence-based, comprehensive and psychometrically va...

journal_title：Vaccine

authors： Brown KF,Shanley R,Cowley NA,van Wijgerden J,Toff P,Falconer M,Ramsay M,Hudson MJ,Green J,Vincent CA,Kroll JS,Fraser G,Sevdalis N

更新日期：2011-02-11 00:00:00

abstract：:The recent introductions of highly pathogenic avian influenza (HPAI) H5N1 virus in wild birds and its subsequent spread throughout Asia, the Middle East, Africa and Europe has put a focus on the role of wild birds in the geographical spread of HPAI H5N1 virus. Large-scale surveillance programs are ongoing to determine...

journal_title：Vaccine

authors： Munster VJ,Fouchier RA

更新日期：2009-10-23 00:00:00