HBV serological markers of vaccinated children in remote areas of Taiwan: emphasis on factors contributing to vaccine failure.

Abstract:

:A serosurvey targeting Hepatitis B virus (HBV)-vaccinated children born between 1986 and 1998 was conducted in 2001 in remote Taiwanese villages where a 1993 serosurvey indicated high vaccine failure. The HBV S antigen (HBsAg) seropositive rate among vaccinees of 3-6-year-old children in 2001 was significantly lower than that of 1993 and was higher among children who had a delayed vaccination schedule and received the plasma-derived vaccine. Vaccine escape variants were more prevalent among recipients of recombinant HBV vaccine residing in Hualien. Our study highlights the importance of continued monitoring of vaccinees for incidence of HBV infection in order to refine future vaccination policy.

journal_name

Vaccine

journal_title

Vaccine

authors

Huang ML,Liao WL,Ho MS

doi

10.1016/j.vaccine.2007.06.022

subject

Has Abstract

pub_date

2007-08-21 00:00:00

pages

6326-33

issue

34

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(07)00699-8

journal_volume

25

pub_type

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