Abstract:
:This study evaluated the seroprevalence of poliovirus types 1, 2 and 3 antibodies and vaccination coverage in 780 subjects aged between 7 months and 39 years in Montevideo, Uruguay, where oral polio vaccine (OPV) is used. Antibody titers were measured and seroprotection rates and geometric mean titers (GMTs) were compared among four age groups. Vaccination histories were recorded from documents and interviews. Seroprotection rates ranged from 72% to 95% in children aged 7-23 months, 31-77% in 2-9-year olds, 14-45% in 10-19-year olds and 20-59.5% in 20-39-year olds. Seroprotection decreased significantly with increasing age (p<0.05). Polio vaccination coverage was >90% for the two youngest age groups. These results could help guide public policy decisions regarding polio vaccination, and support the use of inactivated polio vaccine following cessation of OPV.
journal_name
Vaccinejournal_title
Vaccineauthors
Pírez MC,Olivera I,Diabarboure H,Montano A,Barañano R,Badía F,Bonnet MCdoi
10.1016/j.vaccine.2009.02.042subject
Has Abstractpub_date
2009-05-05 00:00:00pages
2689-94issue
20eissn
0264-410Xissn
1873-2518pii
S0264-410X(09)00285-0journal_volume
27pub_type
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