Abstract：
:The potential outcomes of a Phase II schistosomiasis vaccine trial are explored using mathematical models which assume some natural immunity and a vaccine providing partial protection for a limited time. Analyses suggest that vaccination may have only a limited impact on life-long cumulative worm burdens and may lead to increased susceptibility and higher worm burdens at some ages, a "rebound" effect which results reduced opportunity to acquire natural immunity. There is a trade-off between the degree and duration of vaccine-induced protection; long-lived vaccines may be preferable to vaccines giving greater protection but for a shorter time.
journal_name
Vaccinejournal_title
Vaccineauthors
Woolhouse MEdoi
10.1016/0264-410x(95)00083-dsubject
Has Abstractpub_date
1995-08-01 00:00:00pages
1045-50issue
12eissn
0264-410Xissn
1873-2518pii
0264410X9500083Djournal_volume
13pub_type
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