当前位置： SCI文献检索 > VACCINE期刊下所有文献 > Delayed progression of murine AIDS in C57BL/6 mice pre-immunized with a highly antigenic 10-mer peptide encoded by the murine AIDS defective virus gag p12 gene.

Delayed progression of murine AIDS in C57BL/6 mice pre-immunized with a highly antigenic 10-mer peptide encoded by the murine AIDS defective virus gag p12 gene.

Abstract：

:C57BL/6 (B6) mice were immunized with a highly antigenic 10-mer peptide (P12-10), which is encoded by the murine AIDS (MAIDS) defective virus gag p12 gene, emulsified in incomplete Freund's adjuvant (ICFA). One week later, the mice were inoculated with the MAIDS virus to see if the immunization affects progression of MAIDS. It was demonstrated that the immunization significantly delayed progression of MAIDS, although it failed to induce appreciable cytotoxic T lymphocyte (CTL) responses against the P12-10 antigen. In contrast, immunization of B6 mice with the P12-10 coupled with liposome induced substantial CTL responses but failed to protect the mice against MAIDS development. This segregation between CTL activity and in vivo protection efficacy might be worth considering when we exploit vaccines for augmenting cellular immunity mediated by CD8+ T cells.

journal_name

Vaccine

journal_title

Vaccine

authors

Mizuochi T,Horino A,Uchida T

doi

10.1016/s0264-410x(98)00082-6

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

2026-30

issue

20

eissn

0264-410X

issn

1873-2518

pii

S0264410X98000826

journal_volume

16

pub_type

杂志文章

相关文献

VACCINE文献大全
  • Economics of polio vaccination in the post-eradication era: should OPV-using countries adopt IPV?

    abstract：:The continued use of oral polio vaccine (OPV) poses a threat to polio virus eradication. Stopping all polio vaccination in the post-certification era is no longer considered to be a practical option. Policy makers agree that OPV use must stop immediately after certification. Therefore, the pragmatic alternative is for...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.02.008

    authors： Khan MM

    更新日期：2008-04-07 00:00:00

  • Live oral typhoid vaccine Salmonella Typhi Ty21a - a surrogate vaccine against non-typhoid salmonella?

    abstract：BACKGROUND:Non-typhoid Salmonella (NTS) is a leading cause of food-borne illness with more than 90 million annual cases and an emerging antimicrobial resistance among the strains worldwide. Paradoxically, no vaccines are available against these pathogens. Numerous NTS strains share surface O-antigens with Salmonella en...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.10.002

    authors： Kantele A,Pakkanen SH,Siitonen A,Karttunen R,Kantele JM

    更新日期：2012-11-26 00:00:00

  • Critical prevalence of antibodies minimizing vaccination costs for hepatitis A, hepatitis B, varicella, measles and tetanus in adults and adolescents in Catalonia, Spain.

    abstract：:The prevalence of seropositive individuals that makes costs of vaccinating all individuals equal to that for screening and vaccination of susceptible individuals is defined as the critical prevalence of antibodies (p*). Screening and vaccination is more efficient when the prevalence of seropositive individuals (p) in ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.03.048

    authors： Plans-Rubió P

    更新日期：2004-09-28 00:00:00

  • The effect of pre-existing adenovirus-specific immunity on immune responses induced by recombinant adenovirus expressing glycoprotein D of bovine herpesvirus type 1.

    abstract：:We investigated whether pre-existing adenovirus-specific immunity influenced the development of immunity to a foreign antigen expressed by recombinant adenovirus. Active adenovirus-specific immunity was induced in cotton rats by i.n. administration of wild type human adenovirus type 5 (HAd5) two weeks before immunisat...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/s0264-410x(98)00279-5

    authors： Papp Z,Babiuk LA,Baca-Estrada ME

    更新日期：1999-02-26 00:00:00

  • The cost effectiveness of influenza vaccination for adults aged 50 to 64 years: a model-based analysis for Spain.

    abstract：:An economic evaluation of reducing the age threshold for routine influenza vaccination in Spain from 65 to 50 years was performed. A probabilistic model was used to compare a policy based on a recommendation to vaccinate all adults aged 50-64 with the existing vaccination policy for that age group, during interpandemi...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.07.033

    authors： Aballéa S,De Juanes JR,Barbieri M,Martin M,Chancellor J,Oyagüez I,Verwee B,Largeron N

    更新日期：2007-09-28 00:00:00

  • Modeling the effects of influenza vaccination of health care workers in hospital departments.

    abstract：:Nowadays health care worker (HCW) vaccination is widely recommended. Although the benefits of this strategy have been demonstrated in long-term care settings, no studies have been performed in regular hospital departments. We adapt a previously developed model of influenza transmission in a long-term care nursing home...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.07.104

    authors： van den Dool C,Bonten MJ,Hak E,Wallinga J

    更新日期：2009-10-19 00:00:00

  • Improved HIV-1 specific T-cell responses by short-interval DNA tattooing as compared to intramuscular immunization in non-human primates.

    abstract：:The new intradermal DNA delivery technique, termed DNA tattooing might overcome the discrepancy between the encouraging immunogenicity results obtained with DNA vaccines in murine studies and the poor results obtained in non-human primates and humans, the so called "simian barrier". Here, we demonstrate a 10- to 100-f...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.03.091

    authors： Verstrepen BE,Bins AD,Rollier CS,Mooij P,Koopman G,Sheppard NC,Sattentau Q,Wagner R,Wolf H,Schumacher TN,Heeney JL,Haanen JB

    更新日期：2008-06-19 00:00:00

  • Elucidation of the full genetic information of Japanese rubella vaccines and the genetic changes associated with in vitro and in vivo vaccine virus phenotypes.

    abstract：:Rubella is a mild disease characterized by low-grade fever, and a morbilliform rash, but causes congenital defects in neonates born from mothers who suffered from rubella during the pregnancy. After many passages of wild-type rubella virus strains in various types of cultured cells, five live attenuated rubella vaccin...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.01.016

    authors： Otsuki N,Abo H,Kubota T,Mori Y,Umino Y,Okamoto K,Takeda M,Komase K

    更新日期：2011-02-24 00:00:00

  • Can the vaccine adverse event reporting system be used to increase vaccine acceptance and trust?

    abstract：:Vaccine refusal has an impact on public health, and the human pappillomavirus (HPV) vaccine is particularly underutilized. Research suggests that it may be difficult to change vaccine-related attitudes, and there is currently no good evidence to recommend any particular intervention strategy. One reason for vaccine he...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2016.03.087

    authors： Scherer LD,Shaffer VA,Patel N,Zikmund-Fisher BJ

    更新日期：2016-05-05 00:00:00

  • Immunogenicity and protective efficacy of recombinant Haemophilus parasuis SH0165 putative outer membrane proteins.

    abstract：:Haemophilus parasuis (H. parasuis), the causative agent of swine polyserositis, polyarthritis, and meningitis, is one of the most important bacterial diseases of pigs worldwide. Little vaccines currently exist that have a significant effect on infections with all pathogenic serovars of H. parasuis. H. parasuis putativ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.11.003

    authors： Fu S,Zhang M,Xu J,Ou J,Wang Y,Liu H,Liu J,Chen H,Bei W

    更新日期：2013-01-02 00:00:00

  • Clearing asymptomatic parasitaemia increases the specificity of the definition of mild febrile malaria.

    abstract：:In clinical trials, the specificity of the disease endpoint is critical to an accurate estimate of vaccine efficacy. We used a logistic regression model to analyse parasite densities among children before and after treatment with antimalarials, in order to estimate the impact that clearing asymptomatic parasitaemia ha...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.07.057

    authors： Bejon P,Mwangi T,Lowe B,Peshu N,Hill AV,Marsh K

    更新日期：2007-11-23 00:00:00

  • Association of HLA class II genes with clinical hyporesponsiveness to trivalent inactivated influenza vaccine in children.

    abstract：BACKGROUND:The primary prevention measure for influenza infection has been the use of influenza vaccines. However, even when the vaccine and circulating strains are well-matched, some healthy children do not respond to the vaccine, likely due to a genetic basis for immune hyporesponsiveness. The primary objective of th...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.12.026

    authors： Narwaney KJ,Glanz JM,Norris JM,Fingerlin TE,Hokanson JE,Rewers M,Hambidge SJ

    更新日期：2013-02-04 00:00:00

  • Long-term effectiveness of zoster vaccine live for postherpetic neuralgia prevention.

    abstract：BACKGROUND:Postherpetic neuralgia (PHN) occurs in 5-30% of individuals with herpes zoster (HZ) and is characterized by long-lasting pain. Zoster vaccine live (ZVL) is licensed for people 50 years and older to prevent HZ and PHN. This study evaluated vaccine effectiveness (VE) of ZVL against PHN. METHODS:We conducted a...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.07.004

    authors： Klein NP,Bartlett J,Fireman B,Marks MA,Hansen J,Lewis E,Aukes L,Saddier P

    更新日期：2019-08-23 00:00:00

  • Cost-effectiveness of childhood rotavirus vaccination in Taiwan.

    abstract：OBJECTIVE:Rotavirus is the most common cause of severe diarrhea in children. Two rotavirus vaccines (RotaTeq and Rotarix) have been licensed in Taiwan. We have investigated whether routine infant immunization with either vaccine could be cost-effective in Taiwan. METHODS:We modeled specific disease outcomes including ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.01.023

    authors： Wu CL,Yang YC,Huang LM,Chen KT

    更新日期：2009-03-04 00:00:00

  • Brucella abortusΔcydCΔcydD and ΔcydCΔpurD double-mutants are highly attenuated and confer long-term protective immunity against virulent Brucella abortus.

    abstract：:We constructed double deletion (ΔcydCΔcydD and ΔcydCΔpurD) mutants from virulent Brucella abortus biovar 1 field isolate (BA15) by deleting the genes encoding an ATP-binding cassette-type transporter (cydC and cydD genes) and a phosphoribosylamine-glycine ligase (purD). Both BA15ΔcydCΔcydD and BA15ΔcydCΔpurD double-mu...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.11.030

    authors： Truong QL,Cho Y,Park S,Kim K,Hahn TW

    更新日期：2016-01-04 00:00:00

  • Plaque purification as a method to mitigate the risk of adventitious-agent contamination in influenza vaccine virus seeds.

    abstract：:At present, the seed viruses for the manufacture of licensed seasonal inactivated influenza vaccines in the United States are derived from primary egg isolates as a result of concerns associated with adventitious agents. According to the prevailing view, the passage of influenza viruses through eggs serves as a filter...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.02.041

    authors： Murata H,Macauley J,Lewis AM Jr,Peden K

    更新日期：2011-04-12 00:00:00

  • Variable-number tandem repeat markers for identification of Brucella abortus 82 and 75/79-AV vaccine strains.

    abstract：:In Russia, live vaccine strains Brucella abortus 82 and B. abortus 75/79-AV have been widely and extensively utilized for specific prophylaxis of cattle brucellosis. To differentiate these vaccine strains from each other and laboratory collection of other vaccine (n=4), reference (n=15) and field Brucella strains (n=6...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.03.051

    authors： Kulakov YK,Zheludkov MM,Sclyarov OD

    更新日期：2010-10-01 00:00:00

  • Recombinant retrovirus-derived virus-like particle-based vaccines induce hepatitis C virus-specific cellular and neutralizing immune responses in mice.

    abstract：:While the immunological correlates of hepatitis C virus (HCV)-specific immunity are not well understood, it is now admitted that an effective vaccine against HCV will need to induce both cellular and humoral immune responses and address viral heterogeneity to prevent immune escape. We developed a vaccine platform spec...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.05.025

    authors： Huret C,Desjardins D,Miyalou M,Levacher B,Amadoudji Zin M,Bonduelle O,Combadière B,Dalba C,Klatzmann D,Bellier B

    更新日期：2013-03-01 00:00:00

  • Influenza vaccination policies for health workers in low-income and middle-income countries: A cross-sectional survey, January-March 2020.

    abstract：INTRODUCTION:The World Health Organization (WHO) recommends vaccination of health workers against influenza, but uptake in low-resource settings remains low. To complement routine global data collection efforts we conducted a detailed survey on influenza vaccination policies for health workers in low-income and middle-...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2020.10.001

    authors： Maltezou HC,Theodoridou K,Tseroni M,Raftopoulos V,Bolster A,Kraigsley A,Bresee J,Lambach P

    更新日期：2020-11-03 00:00:00

  • Vaccination with human papillomavirus type 16-derived peptides using a tattoo device.

    abstract：:Tattooing has been shown to be very efficient at inducing immunity by vaccination with DNA vaccines. In this study, we examined the usability of tattooing for delivery of peptide vaccines. We compared tattooing with subcutaneous (s.c.) needle injection using peptides derived from human papillomavirus type 16 (HPV16) p...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.03.073

    authors： Pokorná D,Poláková I,Kindlová M,Dusková M,Ludvíková V,Gabriel P,Kutinová L,Müller M,Smahel M

    更新日期：2009-06-02 00:00:00

  • Epidermal powder immunization against influenza.

    abstract：:Epidermal powder immunization (EPI) can efficiently deliver powdered protein vaccines to the epidermis. A phase I clinical trial was conducted to evaluate powdered trivalent influenza vaccine delivered using the PowderJect ND5.2 delivery system. Subjects received either Fluvirin IM injection (15 microg of each influen...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.vaccine.2004.06.041

    authors： Dean HJ,Chen D

    更新日期：2004-12-16 00:00:00

  • Catching-up with pentavalent vaccine: Exploring reasons behind lower rotavirus vaccine coverage in El Salvador.

    abstract：:Rotavirus vaccine was introduced in El Salvador in 2006 and is recommended to be given concomitantly with DTP-HepB-Haemophilus influenzae type b (pentavalent) vaccine at ages 2 months (upper age limit 15 weeks) and 4 months (upper age limit 8 months) of age. However, rotavirus vaccination coverage continues to lag beh...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.07.092

    authors： Suarez-Castaneda E,Burnett E,Elas M,Baltrons R,Pezzoli L,Flannery B,Kleinbaum D,de Oliveira LH,Danovaro-Holliday MC

    更新日期：2015-11-27 00:00:00

  • Immunogenicity and reactogenicity of co-administered tetanus-diphtheria-acellular pertussis (Tdap) and tetravalent meningococcal conjugate (MCV4) vaccines compared to their separate administration.

    abstract：:In the United States, co-administration of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine and tetravalent meningococcal conjugate vaccine (MCV4) is recommended in adolescents. In this clinical study, 1341 adolescents received Tdap (Boostrix® GlaxoSmithKline) and MCV4 (Menactra®, Sanof...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2010.11.057

    authors： Weston WM,Friedland LR,Wu X,Howe B

    更新日期：2011-01-29 00:00:00

  • Pulcherrimasaponin, from the leaves of Calliandra pulcherrima, as adjuvant for immunization in the murine model of visceral leishmaniasis.

    abstract：:A novel triterpenoidal saponin, called pulcherrimasaponin (CP05), isolated from the leaves of Calliandra pulcherrima Benth. shows remarkable similarities to the previously described potent adjuvant, QS21 saponin (Quillaja saponaria Molina). On the basis of chemical and physicochemical evidence, its structure was estab...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2004.08.022

    authors： Silva BP,Soares JB,Souza EP,Palatnik M,Sousa CB,Parente JP

    更新日期：2005-01-11 00:00:00

  • Immunogenicity and protection conferred by an optimized purified inactivated Zika vaccine in mice.

    abstract：:After decades of inconsequential infections, and sporadic outbreaks in the Asia-Pacific region between 2007 and 2013, Zika virus caused a widespread epidemic in South America in 2015 that was complicated by severe congenital infections. After the WHO declared a Public Health Emergency of International Concern in Febru...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.04.013

    authors： Lecouturier V,Bernard MC,Berry C,Carayol S,Richier E,Boudet F,Heinrichs J

    更新日期：2019-05-06 00:00:00

  • Risk factors for human papillomavirus exposure and co-factors for cervical cancer in Latin America and the Caribbean.

    abstract：:The incidence of cervical cancer in Latin America and the Caribbean (LAC) is among the highest in the world. Because there are major demographic shifts happening in LAC countries (population growth, urbanization and ageing) cervical cancer incidence and mortality will likely continue to be a significant public health ...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2008.06.008

    authors： Almonte M,Albero G,Molano M,Carcamo C,García PJ,Pérez G

    更新日期：2008-08-19 00:00:00

  • Lessons learned in the analysis of high-dimensional data in vaccinomics.

    abstract：:The field of vaccinology is increasingly moving toward the generation, analysis, and modeling of extremely large and complex high-dimensional datasets. We have used data such as these in the development and advancement of the field of vaccinomics to enable prediction of vaccine responses and to develop new vaccine can...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.04.088

    authors： Oberg AL,McKinney BA,Schaid DJ,Pankratz VS,Kennedy RB,Poland GA

    更新日期：2015-09-29 00:00:00

  • A canine adenovirus type 2 vaccine vector confers protection against foot-and-mouth disease in guinea pigs.

    abstract：:Vaccination is a key element in the control of foot-and-mouth disease (FMD). The majority of the antigenic sites that induce protective immune responses are localized on the FMD virus (FMDV) capsid that is formed by four virus-encoded structural proteins, VP1 to VP4. In the present study, recombinant canine adenovirus...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.02.074

    authors： De Vleeschauwer AR,Zhou X,Lefebvre DJ,Garnier A,Watier F,Pignon C,Lacour SA,Zientara S,Bakkali-Kassimi L,De Clercq K,Klonjkowski B

    更新日期：2018-04-12 00:00:00

  • Genotypic and phenotypic characterization of West Nile virus NS5 methyltransferase mutants.

    abstract：:Although West Nile virus (WNV) causes annual cases of neurological disease and deaths in humans, a vaccine has not been licensed for human use. Several WNV genes have been targeted for mutagenesis in attempts to generate live attenuated vaccine candidates, including the non-structural protein NS5. Specifically, mutati...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.09.045

    authors： Kaiser JA,Luo H,Widen SG,Wood TG,Huang CY,Wang T,Barrett ADT

    更新日期：2019-11-15 00:00:00

  • Immune response to a Tdap booster in vertically HIV-infected adolescents.

    abstract：BACKGROUND:Pertussis cases have increased worldwide and knowledge on immune response and cytokine profile after Tdap vaccine in immunodeficient adolescents is scarce. OBJECTIVE:To evaluate the immune response after Tdap in HIV-infected (HIV) and in healthy adolescents (CONTROL). METHODOLOGY:Thirty HIV adolescents wit...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2018.07.043

    authors： Spina FG,Gouvea A,Succi RCM,Calanca F,Weckx LY,Terreri MT,Takano MAS,de Moraes-Pinto MI

    更新日期：2018-09-05 00:00:00