Abstract：
:In clinical trials, the specificity of the disease endpoint is critical to an accurate estimate of vaccine efficacy. We used a logistic regression model to analyse parasite densities among children before and after treatment with antimalarials, in order to estimate the impact that clearing asymptomatic parasitaemia had on the specificity of the endpoint of febrile malaria. The malaria attributable fever fraction was higher after antimalarial treatment (i.e. fever and parasitaemia were more likely to be causally related), implying that drug treatment prior to monitoring decreased the misclassification of febrile malaria. In intervention studies with febrile malaria as an endpoint, clearing asymptomatic parasitaemia increases the study's power more effectively than raising the threshold parasitaemia.
journal_name
Vaccinejournal_title
Vaccineauthors
Bejon P,Mwangi T,Lowe B,Peshu N,Hill AV,Marsh Kdoi
10.1016/j.vaccine.2007.07.057subject
Has Abstractpub_date
2007-11-23 00:00:00pages
8198-202issue
48eissn
0264-410Xissn
1873-2518pii
S0264-410X(07)00894-8journal_volume
25pub_type
杂志文章相关文献
VACCINE文献大全abstract：BACKGROUND:Poliomyelitis is endemic in Northern Nigeria where there is continuous transmission of wild poliovirus 1 and 3 (WPV1 and 3) and circulating vaccine derived poliovirus 2 (cVDPV2) resulting in a high number of cases of children with acute flaccid paralysis. The seroprevalence of antibodies to polio serotypes w...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.09.023
更新日期：2012-11-06 00:00:00
abstract：:In a phase I/II dose escalation study, varying volumes (0.1 ml, 0.5 ml, 1.0 ml and 2.0 ml) of 7-valent pneumococcal conjugate vaccine (PCV) (Prevnar or 0.5 ml of 23-valent pneumococcal polysaccharide vaccine (PPV) were administered to 220 adults 70 through 79 years of age previously vaccinated with 0.5 ml PPV at age 6...
journal_title：Vaccine
pub_type： 临床试验,杂志文章
doi：10.1016/j.vaccine.2005.02.017
更新日期：2005-05-25 00:00:00
abstract：:It is generally accepted that the introduction of hepatitis B vaccine to national programmes of immunization in developing countries is desirable, but it has so far been constrained by the high cost of the vaccine. To determine the potential minimal costs of the vaccine, a study has been carried out of the production ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(90)90101-q
更新日期：1990-08-01 00:00:00
abstract：:Influenza H3N2 viruses have recently drifted from A/Wisconsin/67/05-like to A/Brisbane/10/07-like viruses. The effect of key amino acid substitutions in the hemagglutinin (HA) protein on the replication, antigenicity and immunogenicity of cold-adapted, live attenuated vaccine strains was examined. A/Brisbane/10/07 egg...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.03.078
更新日期：2010-05-28 00:00:00
abstract：:Few suspension cells can be used for vaccine manufacturing today as they either do not meet requirements from health regulatory authorities or do not produce high virus titres. Two new avian designer cell lines (AGE1.CR and AGE1.CR.pIX) that have been adapted to grow in suspension in serum-free medium were evaluated f...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.05.083
更新日期：2009-08-06 00:00:00
abstract：:Infection with influenza virus during pregnancy poses a significant risk of complications for both mother and fetus. During the H1N1 2009 pandemic, pregnant women constituted one of the priority groups for vaccination in many countries, creating a need for close monitoring of the safety of the vaccine in pregnant wome...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.04.114
更新日期：2011-08-26 00:00:00
abstract：:The adjuvant properties of polyglucosamine/squalene-based nanocapsules (PG-nanocapsules) associated with different subunit antigens has been previously reported. Thus, the aim of the present study was to monitor the biodistribution of PG-nanocapsules and their affinity for the draining lymph nodes after subcutaneous (...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.01.059
更新日期：2014-03-26 00:00:00
abstract：:Successful vaccination of mice against an otherwise lethal challenge with the Peru strain of Trypanosoma cruzi necessitates the induction of a strong cell mediated immune response. Previously, immunization of mice with the paraflagellar rod proteins from Trypanosoma cruzi90% reduction in parasitemia in immunized mice ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(99)00380-1
更新日期：2000-01-31 00:00:00
abstract：:Ticks (Acari: Ixodidae) are considered to be the most important vectors of disease-causing pathogens in domestic and wild animals, and emerging and re-emerging tick-borne diseases (TBD) exert an enormous impact on them. Wild ungulates are hosts for a wide variety of tick species and tick-borne pathogens that affect hu...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.07.062
更新日期：2020-09-22 00:00:00
abstract：:Haemophilus parasuis (H. parasuis) is a swine pathogen responsible for the Glässer's disease, which has received more attention in the past decade due to the increasing economic losses in the pig industry worldwide. As traditional inactive vaccine of H. parasuis has obvious disadvantage, to identify efficient immunopr...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.02.023
更新日期：2015-03-30 00:00:00
abstract：:Generating broadly neutralizing antibodies with candidate vaccines has remained an elusive goal. Consequently, vaccine candidates developed have aimed at eliciting cell-mediated immune effector activities (CMI) that could delay disease progression, and maybe also limit secondary transmission, by controlling virus repl...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2009.01.039
更新日期：2009-03-23 00:00:00
abstract：:After the publication of case reports of hepatitis B vaccinees with onset or relapse of multiple sclerosis (MS), followed by a media-driven scare campaign in France, the perception that hepatitis B vaccine causes MS has developed. This has led to a fall in the acceptance of hepatitis B vaccination particularly in Fren...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(99)00533-2
更新日期：2000-04-03 00:00:00
abstract：BACKGROUND:Females who receive the human papillomavirus (HPV) vaccine may believe they are protected from developing cervical cancer and no longer require screening. Concern has also been expressed that vaccinated females are those that would be screened regularly. This study assesses the Pap testing behavior of vaccin...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2013.10.082
更新日期：2013-12-17 00:00:00
abstract：:The level of antibody production induced by a vaccine involves a variety of host factors. One of these, insulin-like growth factor-1 (IGF-1), plays an important role in lymphocyte maturation and antibody expression. Here, we investigated the role of macrophage-derived IGF-1 in the induction of influenza vaccine-specif...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.07.037
更新日期：2017-08-24 00:00:00
abstract：:ArtinM and Jacalin (JAC) are lectins from the jackfruit (Artocarpus integrifolia) that have important role in modulation of immune responses to pathogens. Neospora caninum is an Apicomplexa parasite that causes neuromuscular disease in dogs and reproductive disorders in cattle, with economic impact on the livestock in...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.09.136
更新日期：2011-11-15 00:00:00
abstract：:Groups of calves (20 per group) were vaccinated subcutaneously with a single dose of BCG Pasteur (6 x 10(4) or 6 x 10(6) colony forming units) and two months later, 15 calves from each group were challenged intratracheally with virulent Mycobacterium bovis. Vaccination with either dose of BCG induced significant prote...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(94)00055-r
更新日期：1995-08-01 00:00:00
abstract：:Plasmid DNA encoding herpes simplex virus type-1 glycoprotein D (gD-1) was complexed with asialoorosomucoid conjugated to poly-L-lysine. Following its intravenous injection into BALB/c mice, this complex was targeted to the liver. Liver cells expressing gD-1 were detected immunohistochemically through day 6 post-immun...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(99)00438-7
更新日期：2000-02-14 00:00:00
abstract：:Viral hepatitis B is an enigmatic disease in which the host's own immune response to persistent viral infection may bring about host destruction through antiviral inflammatory responses which might otherwise present as a benign or inapparent disease. The simple solution to the hepatitis B problem is by immunoprophylax...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/s0264-410x(03)00529-2
更新日期：2003-12-01 00:00:00
abstract：BACKGROUND:The Institute of Medicine, in a 2013 report, recommended that the Vaccine Safety Datalink (VSD) expand collaborations to include more diversity in the study population. Kaiser Permanente Colorado (KPCO), an established VSD site, partnered with Denver Health (DH), an integrated safety net healthcare system, t...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.01.017
更新日期：2017-03-01 00:00:00
abstract：:The aim of this study is to provide estimates on the incidence of rotavirus infection requiring hospitalization in children journal_title：Vaccine pub_type： 杂志文章 doi：10.1016/j.vaccine.2003.11.037 更新日期：2004-06-02 00:00:00
abstract：:Dendritic cells (DC) play an integral role in plasmid DNA vaccination. However, the interaction between plasmid DNA and DC in vivo is incompletely understood. In this report, we utilise the sheep pseudoafferent cannulation model to examine the interaction between plasmid DNA encoding enhanced green fluorescent protein...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.03.023
更新日期：2005-07-21 00:00:00
abstract：:A cost-effectiveness analysis of the introduction of acellular pertussis booster doses at either 4 or 15 years of age was performed. A transmission dynamic model was used to predict the level of indirect protection in those too young to be vaccinated. Multivariate sensitivity analyses were performed. In England and Wa...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(01)00473-x
更新日期：2002-01-31 00:00:00
abstract：:Influenza A/H1N1 new vaccine helps control disease spread. Cross-sectional survey was conducted at PHC & Emergency Departments in Qatar to determine influenza A/H1N1 vaccination rate among HCWs and associated factors, 523 HCWs were enrolled. The study showed that 13.4% HCWs received vaccination. Feeling protected stro...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.08.093
更新日期：2011-03-03 00:00:00
abstract：:During the 2009/10 pandemic of influenza A (H1N1), the American Society of Transplantation and other health organizations recommended that immunocompromised patients should be vaccinated as the key preventive measure. Since there are no data available for the immunogenicity of the unadjuvanted pandemic influenza vacci...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.07.050
更新日期：2011-09-16 00:00:00
abstract：OBJECTIVE:To assess whether recipients and non-recipients of the human papillomavirus (HPV) vaccine subsequently differ in terms of sexual risk taking behaviour. DESIGN:Cross-sectional survey. Sequential analyses constructed from self-reported age at vaccination, age at first intercourse and age at response. SETTING:...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.07.025
更新日期：2014-09-03 00:00:00
abstract：:The role of the defect in erythritol catabolism in the attenuated virulence of Brucella abortus B19 vaccine strain in mice was investigated by means of five different strains: (i) the erythritol sensitive B19 vaccine strain; (ii) a natural erythritol tolerant (NET) mutant obtained spontaneously from B19; (iii) an eryt...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(98)00063-2
更新日期：1998-10-01 00:00:00
abstract：:Foot and Mouth Disease (FMD) is an acute disease caused by Foot and Mouth Disease Virus (FMDV) which causes important economy losses, this is why it is necessary to obtain a vaccine that stimulates a rapid and long-lasting protective immune response. Cliptox is a mineral microparticle that in earlier studies has shown...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.06.098
更新日期：2010-08-31 00:00:00
abstract：:Protection against diseases caused by the avian viruses, Marek's disease, Infectious laryngotracheitis, chicken anemia and turkey meningoencephalitis is achieved by live vaccines. The application quality is important to assure proper uptake in commercial flocks. We describe a novel evaluation method for the vaccinatio...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.12.052
更新日期：2018-01-29 00:00:00
abstract：:The predominant route of HIV infection is through the sexual transmission via M cells. Most of the peptide and protein vaccines show poor transport across the epithelial barrier and are commonly administered by parenteral route. In the present study four HIV peptides from envelope (gp 41-LZ (leucine zipper), gp 41-FD ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.06.031
更新日期：2005-12-01 00:00:00
abstract：:Vaccination is an effective strategy to prevent pneumococcal diseases. Currently, licensed vaccines include the pneumococcal polysaccharide vaccine (PPSV) and the pneumococcal conjugate vaccine (PCV), which target some of the most common of the 94 serotypes of S. pneumoniae based on their capsular composition. However...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2018.11.015
更新日期：2019-01-03 00:00:00
