Molecular shape and immunogenicity of meningococcal polysaccharide group A conjugate vaccine.

Abstract:

:Neisseria meningitidis is a leading cause of severe bacterial infections in infants and young children. As a major virulence factor, meningococcal capsular polysaccharide (PS) is poorly immunogenic and generally does not induce immunological memory. Conjugation of PS with a carrier protein can significantly increase the PS-specific immunogenicity and induce immunological memory. It is well known that the molecular shape/size of the conjugate vaccine is important for its immunogenicity. However, little is known about the molecular shape/size of the meningococcal conjugate vaccine. A meningococcal PS-ovalbumin (OVA) conjugate vaccine was prepared using cystamine as linker. Four components (P1-P4) with different molecular size were fractionated from the conjugate. Small angle X-ray scattering (SAXS) analysis revealed that the conjugate vaccine exhibited a rod-like shape similar to virus-like particles. PS-specific immunogenicity of the conjugate vaccine was related to its molecular shape and increased as a function of its molecular size. Thus, the present study provides a three-dimensional shape of the conjugate vaccine and helps to identify optimal design of a potent meningococcal conjugate vaccine.

journal_name

Vaccine

journal_title

Vaccine

authors

Xu M,Xing X,Wu Z,Du Y,Hu T

doi

10.1016/j.vaccine.2015.09.021

subject

Has Abstract

pub_date

2015-10-26 00:00:00

pages

5815-5821

issue

43

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(15)01285-2

journal_volume

33

pub_type

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