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Cooperative binding of anti-tetanus toxin monoclonal antibodies: Implications for designing an efficient biclonal preparation to prevent tetanus toxin intoxication.

Abstract：

:Oligoclonal combinations of several monoclonal antibodies (MAbs) are being considered for the treatment of various infectious pathologies. These combinations are less sensitive to antigen structural changes than individual MAbs; at the same time, their characteristics can be more efficiently controlled than those of polyclonal antibodies. The main goal of this study was to evaluate the binding characteristics of six biclonal equimolar preparations (BEP) of tetanus toxin (TeNT)-specific MAbs and to investigate how the MAb combination influences the BEPs' protective capacity. We show that a combination of TeNT-specific MAbs, which not only bind TeNT but also exert positive cooperative effects, results in a BEP with superior binding characteristics and protective capacity, when compared with the individual component MAbs. Furthermore, we show that a MAb with only partial protective capacity but positive effects on the binding of the other BEP component can be used as a valuable constituent of the BEP.

journal_name

Vaccine

journal_title

Vaccine

authors

Lukic I,Filipovic A,Inic-Kanada A,Marinkovic E,Miljkovic R,Stojanovic M

doi

10.1016/j.vaccine.2018.05.058

subject

Has Abstract

pub_date

2018-06-18 00:00:00

pages

3764-3771

issue

26

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(18)30678-9

journal_volume

36

pub_type

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