Abstract:
:Two shots of inactivated Japanese encephalitis (JE) vaccine were given to children, 139 with underlying diseases and 42 healthy, and their antibody responses were studied by the neutralization test. Before vaccination, most of the vaccinees did not have antibody against JE virus. One month after the second vaccination, they were all seroconverted and showed considerably high neutralizing titres. One healthy child developed fever on the day of vaccination without any severe symptoms afterwards, and no side reactions were observed in the handicapped children. These results suggest that the current JE vaccine is safe and can induce a strong immune response even in handicapped children.
journal_name
Vaccinejournal_title
Vaccineauthors
Yamada A,Imanishi J,Juang RF,Fukunaga T,Okuno Y,Tadano M,Fukai K,Baba K,Yabuuchi Hdoi
10.1016/0264-410x(86)90095-2subject
Has Abstractpub_date
1986-03-01 00:00:00pages
32-4issue
1eissn
0264-410Xissn
1873-2518pii
0264-410X(86)90095-2journal_volume
4pub_type
临床试验,杂志文章相关文献
VACCINE文献大全abstract::Dengue disease is a global challenge for healthcare systems particularly during outbreaks, and millions of dollars are spent every year for vector control. An efficient and safe vaccine that is cost-effective could resolve the burden that dengue virus imposes on affected countries. We describe here the immunogenicity ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2015.01.074
更新日期:2015-03-17 00:00:00
abstract::After a single injection of Typhim Vi (typhoid Vi polysaccharide vaccine), serum antibody concentrations were monitored for 3 years in 37 adults who resided where typhoid fever was not endemic. Anti-Vi antibody concentrations declined progressively during the study, to levels that support the current US recommendation...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2009.11.051
更新日期:2010-02-10 00:00:00
abstract::Data from two Swedish pertussis vaccine trials with various combination vaccines were used to compare anti-diphtheria antitoxin concentrations over time between different vaccines, vaccine lots and vaccine schedules. The immune responses were measured with a validated ELISA method.Results are given for 1326 children, ...
journal_title:Vaccine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0264-410x(99)00539-3
更新日期:2000-04-28 00:00:00
abstract::The toxicity of Clostridium difficile large clostridial toxin B (TcdB) can be reduced by many orders of magnitude by a combination of targeted point mutations. However, a TcdB mutant with five point mutations (referred to herein as mTcdB) still has residual toxicity that can be detected in cell-based assays and in-viv...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2014.06.032
更新日期:2015-01-01 00:00:00
abstract::Influenza becomes epidemic worldwide every year, and many individuals receive vaccination annually. Quality control relating to safety and potency of influenza vaccines is important to maintain public confidence. The safety of influenza vaccines has been assessed by clinical trials, and animal safety tests are perform...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2018.09.021
更新日期:2018-10-15 00:00:00
abstract::Vibrio cholerae O139 Bengal strain was the causative agent of the recent epidemics of cholera in India and Bangladesh. We studied antibacterial and antitoxin immune responses in acute and convalescent phase paired sera collected from seven of these cholera patients. Significant rise in the levels of both antibacterial...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(96)00035-7
更新日期:1996-08-01 00:00:00
abstract::We have previously described the generation of HIV-1 V3-specific cytotoxic T-lymphocytes (CTL) responses in BALB/c (H-2d) mice following immunization with Ty-virus-like particles carrying the V3 loop of gp120 (V3-VLPs) without adjuvant. In this study the effects of various adjuvants on CTL induction by V3-VLPs was exa...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(96)00010-2
更新日期:1996-07-01 00:00:00
abstract::Age-specific force of varicella infection, hospitalisation and death rates in non-immune persons were calculated using an age-based mathematical model and national data for France. A cost-effectiveness model was then applied to hypothetical cohorts of persons aged 15-45 years with a negative or uncertain history of va...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(03)00405-5
更新日期:2003-09-08 00:00:00
abstract::Recipients of renal transplants were vaccinated with 20 ng hepatitis B surface antigen aluminium-adsorbed vaccine in order to gauge their resistance to hepatitis B infection, to which these patients are at high risk. The patients were given three 40 micrograms doses of the vaccine over a period of six months and their...
journal_title:Vaccine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0264-410x(84)90039-2
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:This phase I trial evaluated the safety and immunogenicity of a candidate tuberculosis vaccination regimen, ChAdOx1 85A prime-MVA85A boost, previously demonstrated to be protective in animal studies, in healthy UK adults. METHODS:We enrolled 42 healthy, BCG-vaccinated adults into 4 groups: low dose Starter ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2019.10.102
更新日期:2020-01-22 00:00:00
abstract::Potential endpoints for blood stage malaria vaccine efficacy trials include uncomplicated malaria disease, which is hard to differentiate from other febrile illnesses, and mortality, which requires prohibitively large sample sizes. Strictly defined severe malaria predicts malaria-associated mortality where case fatali...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2004.01.054
更新日期:2004-08-13 00:00:00
abstract::Establishing successful vaccine programs for pregnant women would be the quintessence of preventive medicine when you realize the preventive potential for reproductive problems of many of the new and old vaccines. The development of vaccines to prevent maternal, fetal and newborn disease is actually in its infancy. Th...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/s0264-410x(03)00396-7
更新日期:2003-07-28 00:00:00
abstract::Mice immunized with plasmid DNA encoding Nef regulatory protein of human immunodeficiency virus type 1 developed high levels of anti-Nef antibodies. After 4 intramuscular injections of 100 microg plasmid DNA, anti-Nef antibodies reached titers up to 2 x 10(4). A significant specific antibody response was maintained fo...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(99)00203-0
更新日期:1999-09-01 00:00:00
abstract::Immunogenicity of inactivated virus or subviral vaccines may be enhanced by complexing with an IgG antibody. Such antibody would increase the uptake, processing and presentation of the vaccine's antigens by antigen presenting cells (APC), via the adhesion of the antibody-vaccine complex to Fc-receptors on macrophages ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(95)00189-8
更新日期:1996-03-01 00:00:00
abstract::Meningococcal disease is a serious medical condition that can prove fatal within hours in otherwise healthy individuals. Disease incidence is highest in infants, yet there is no broadly protective quadrivalent vaccine that covers this age group. A new investigational quadrivalent meningococcal glycoconjugate vaccine a...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2009.07.036
更新日期:2009-09-18 00:00:00
abstract::Carbopol is a polyanionic carbomer gel used in man for a variety of topical applications and drug delivery purposes. Here we show that subcutaneous administration of carbopol with glycoprotein antigens elicits unusually strong specific adaptive immune responses in mice. Recombinant soluble HIV-1 envelope glycoprotein ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2010.01.046
更新日期:2010-03-16 00:00:00
abstract:INTRODUCTION:Nosocomial outbreaks of seasonal influenza are frequent, and vaccination is largely recommended for healthcare workers (HCWs). Vaccine coverage in French HCWs does not exceed 20%. Decision-aids (DA) are potential useful interventions to increase vaccine coverage (VC). Our aim was to evaluate the impact of ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2020.07.011
更新日期:2020-08-10 00:00:00
abstract::A National Immunization Technical Advisory Group (NITAG) is an expert advisory committee that provides evidence-based recommendations to the Ministry of Health (MoH) to guide immunization programs and policies. The World Health Organization (WHO), the Initiative for Supporting National Independent Immunization and Vac...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2013.01.047
更新日期:2013-05-28 00:00:00
abstract::A highly efficacious vaccine is required to counteract a threat of an avian influenza pandemic. Increasing the potency of vaccines by adjuvation is essential not only to overcome generally low immunogenicity of pandemic strains, but also to allow dose sparing and as such to make it feasible to satisfy huge global prod...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2008.04.071
更新日期:2008-07-04 00:00:00
abstract::The goal of the present study was to evaluate the influence of the influenza A H1N1/2009 vaccine on dermatomyositis/polymyositis (DM/PM) disease parameters and the potential deleterious effect of therapy on immune response. Thirty-seven DM and 21 PM patients (Bohan and Peter's criteria) were gender- and age-matched to...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2012.10.063
更新日期:2012-12-17 00:00:00
abstract::Group B streptococcus (GBS) is a leading cause of neonatal sepsis, with the highest incidence (1.3 per 1000 live births) reported from Africa. Although the incidence of invasive GBS disease is reportedly low in South Asia, there is disconnect between prevalence of maternal recto-vaginal colonization and the incidence ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2017.02.025
更新日期:2017-08-16 00:00:00
abstract::Respiratory syncytial virus (RSV) is the primary cause of serious lower respiratory tract illness in young children. We have engineered a recombinant candidate vaccine G1F/M2, consisting of a cytotoxic T lymphocyte (CTL) epitope of RSV-M2 protein and a domain of RSV-G protein. In this study, the long-term immunogenici...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2007.08.007
更新日期:2007-10-16 00:00:00
abstract::A soluble fraction obtained from Bordetella pertussis was evaluated as adjuvant for the pertussis component of the Diphtheria-Pertussis-Tetanus (DPT) vaccine. High levels of antibodies were induced, and a 78% protection rate of mice challenged with live B. pertussis was observed. Two proteins were identified as the 73...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2006.08.033
更新日期:2007-01-08 00:00:00
abstract::In this study, a recombinant truncated West Nile virus envelope protein antigen (rWNV-E) was produced in serum-free cultures of the expresSF+ insect cell line via baculovirus infection. This production system was selected based on its use in the production of candidate human and animal vaccine antigens. A defined ferm...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2008.10.046
更新日期:2009-01-07 00:00:00
abstract:CONTEXT:The true level of influenza vaccine efficacy is controversial and many factors may influence its estimation. OBJECTIVES:To estimate the efficacy of vaccination of children and non-elderly adults for the prevention of influenza and to explore the impact of type of vaccine, age, degree of strain matching, influe...
journal_title:Vaccine
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.vaccine.2012.10.084
更新日期:2012-12-17 00:00:00
abstract::The objectives of this research were to evaluate the risk of prolonged testicular infection as a consequence of vaccination of peri-pubertal bulls with a modified-live, noncytopathic strain of BVDV and to assess vaccine efficacy in preventing prolonged testicular infections after a subsequent acute infection. Seronega...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2006.09.037
更新日期:2007-01-15 00:00:00
abstract::In order to perform preliminary evaluations of subunit vaccine candidates before extensive trials in large food-producing animals, an in vitro B-lymphocyte response assay, based on the principles of an ELISA, was established. The assay was developed in detail for the porcine system using antigens from the Gram-negativ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(91)90149-z
更新日期:1991-03-01 00:00:00
abstract::Since 2005, the Government of the United States of America has provided more than US$ 50 million to advance influenza vaccine development in low-resourced countries. This programme has provided a unique opportunity for the US Government to develop a comprehensive view of, and to understand better the challenges and fu...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2011.02.080
更新日期:2011-07-01 00:00:00
abstract::Respiratory syncytial virus (RSV) is the most common cause of viral bronchiolitis and pneumonia in children. The present study compares the level of attenuation, genetic stability and efficacy of three conditional-lethal temperature-sensitive (ts) mutants of the RSV A2 wild-type virus, designated ts-1, ts-1-NG1, and t...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/0264-410x(93)90168-w
更新日期:1993-11-01 00:00:00
abstract::Streptococcus suis (S. suis) is a major porcine pathogen causing meningitis, arthritis and several other pathologies. Recently, we identified a highly specific immunoglobulin M degrading enzyme of S. suis, designated IdeSsuis, which is expressed by various serotypes. The objective of this work was to access the immuno...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2015.03.047
更新日期:2015-05-05 00:00:00