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Immunogenicity of experimental live attenuated Japanese encephalitis vaccine viruses and comparison with wild-type strains using monoclonal and polyclonal antibodies.

Abstract：

:A total of 105 hybridomas secreting anti-Japanese encephalitis (JE) virus monoclonal antibodies (mAbs) were generated from six fusions against four strains of JE virus: wild-type strains SA14 and G8924 and live attenuated vaccines SA14-5-3 and SA14-14-2 (PDK-9). Most of the mAbs (87%) elicited haemagglutination inhibition activity while only a minority (24%) elicited neutralization. None of the mAbs prepared against SA14-5-3, parent of SA14-14-2, elicited neutralization while the only mAbs prepared against SA14-14-2 that elicited neutralization recognized flavivirus cross-reactive epitopes. In comparison, mAbs raised against wild-type strains showed that a spectrum of epitopes with different specificities, including JE type-specific epitopes, elicited neutralizing activity. Two mAbs, prepared against SA14-5-3 virus, were found to be vaccine-specific and five, prepared against strains SA14 and G8924, were wild-type-specific.

journal_name

Vaccine

journal_title

Vaccine

authors

Sil BK,Wills MR,Cao JX,Sharda R,Islam MA,Stagg DJ,Jennings AD,Gibson CA,Barrett AD

doi

10.1016/0264-410x(92)90372-q

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

329-33

issue

5

eissn

0264-410X

issn

1873-2518

pii

0264-410X(92)90372-Q

journal_volume

10

pub_type

杂志文章

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