Abstract：
:We explore cellular and molecular mechanisms of nasal adjuvant of a combination of a plasmid encoding the Flt3 ligand cDNA (pFL) and CpG oligodeoxynucleotides (CpG ODN). The double DNA adjuvant given with OVA maintained prolonged OVA-specific secretory IgA (S-IgA) Ab responses in external secretions for more than 25 weeks after the final immunization. Further, both Th1- and Th2-type cytokine responses were induced by this combined adjuvant regimen. The frequencies of plasmacytoid DCs (pDCs) and CD8(+) DCs were significantly increased in nasopharyngeal-associated lymphoreticular tissue (NALT) of mice given the combined adjuvant. Importantly, when we examined adjuvanticity of pFL plus CpG ODN in 2-year-old mice, significant levels of mucosal IgA Ab responses were also induced. These results demonstrate that nasal delivery of a combined DNA adjuvant offers an attractive possibility for the development of an effective mucosal vaccine for the elderly.
journal_name
Vaccinejournal_title
Vaccineauthors
Fukuiwa T,Sekine S,Kobayashi R,Suzuki H,Kataoka K,Gilbert RS,Kurono Y,Boyaka PN,Krieg AM,McGhee JR,Fujihashi Kdoi
10.1016/j.vaccine.2008.06.091subject
Has Abstractpub_date
2008-09-02 00:00:00pages
4849-59issue
37eissn
0264-410Xissn
1873-2518pii
S0264-410X(08)00843-8journal_volume
26pub_type
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