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Immunogenicity of mumps virus vaccine candidates matching circulating genotypes in the United States and China.

Abstract：

:Mumps virus (MuV) causes acute infection in humans with characteristic swelling of the parotid gland. While vaccination has greatly reduced the incidence of MuV infection, there have been multiple large outbreaks of mumps virus (MuV) in highly vaccinated populations. The most common vaccine strain, Jeryl Lynn, belongs to genotype A, which is no longer a circulating genotype. We have developed two vaccine candidates that match the circulating genotypes in the United States (genotype G) and China (genotype F). We found that there was a significant decrease in the ability of the Jeryl Lynn vaccine to produce neutralizing antibody responses to non-matched viruses, when compared to either of our vaccine candidates. Our data suggests that an updated vaccine may allow for better immunity against the circulating MuV genotypes G and F.

journal_name

Vaccine

journal_title

Vaccine

authors

Zengel J,Phan SI,Pickar A,Xu P,He B

doi

10.1016/j.vaccine.2017.05.084

subject

Has Abstract

pub_date

2017-07-13 00:00:00

pages

3988-3994

issue

32

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(17)30752-1

journal_volume

35

pub_type

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