Abstract:
:The 23-valent pneumococcal vaccine has unequal effectiveness in splenectomised patients. We performed a longitudinal study (2005-2008) whose main objective was to characterize the profile of non-responders among splenectomised patients treated at our institution and identify potential predictive indicators of the response to the vaccine. The immune response was evaluated in 96 subjects. The proportion of responders was 70% (95% CI: 60-78%). Immunosuppression (OR=3.19, 95% CI 1.04-9.73) and the reason for splenectomy (hematologic neoplasia versus non-malignant hematologic diseases, OR=7.37, 95% CI 1.71-31.7) were independent predictors of non-response to vaccination. However, the positive predictive value of the model and the likelihood ratio for a positive result were low (PPV=76.6%, 95% CI 66.2-84.4%, LR(+)=1.41, 95% CI 1.08-1.86). We recommend determining the response to pneumococcal vaccine in these patients when possible.
journal_name
Vaccinejournal_title
Vaccineauthors
Llupià A,Vilella A,Costas L,Díez C,Torres F,Yagüe J,Massó M,Muñoz A,Mensa Jdoi
10.1016/j.vaccine.2011.09.073subject
Has Abstractpub_date
2012-03-16 00:00:00pages
2382-6issue
13eissn
0264-410Xissn
1873-2518pii
S0264-410X(11)01492-7journal_volume
30pub_type
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