Can the response to 23-valent pneumococcal vaccine in splenectomised patients be predicted?

Abstract:

:The 23-valent pneumococcal vaccine has unequal effectiveness in splenectomised patients. We performed a longitudinal study (2005-2008) whose main objective was to characterize the profile of non-responders among splenectomised patients treated at our institution and identify potential predictive indicators of the response to the vaccine. The immune response was evaluated in 96 subjects. The proportion of responders was 70% (95% CI: 60-78%). Immunosuppression (OR=3.19, 95% CI 1.04-9.73) and the reason for splenectomy (hematologic neoplasia versus non-malignant hematologic diseases, OR=7.37, 95% CI 1.71-31.7) were independent predictors of non-response to vaccination. However, the positive predictive value of the model and the likelihood ratio for a positive result were low (PPV=76.6%, 95% CI 66.2-84.4%, LR(+)=1.41, 95% CI 1.08-1.86). We recommend determining the response to pneumococcal vaccine in these patients when possible.

journal_name

Vaccine

journal_title

Vaccine

authors

Llupià A,Vilella A,Costas L,Díez C,Torres F,Yagüe J,Massó M,Muñoz A,Mensa J

doi

10.1016/j.vaccine.2011.09.073

subject

Has Abstract

pub_date

2012-03-16 00:00:00

pages

2382-6

issue

13

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(11)01492-7

journal_volume

30

pub_type

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