Monoclonal antibodies for prophylactic and therapeutic use against viral infections.

Abstract:

:Neutralizing antibodies play an essential part in antiviral immunity and are instrumental in preventing or modulating viral diseases. Polyclonal antibody preparations are increasingly being replaced by highly potent monoclonal antibodies (mAbs). Cocktails of mAbs and bispecific constructs can be used to simultaneously target multiple viral epitopes and to overcome issues of neutralization escape. Advances in antibody engineering have led to a large array of novel mAb formats, while deeper insight into the biology of several viruses and increasing knowledge of their neutralizing epitopes has extended the list of potential targets. In addition, progress in developing inexpensive production platforms will make antiviral mAbs more widely available and affordable.

journal_name

Vaccine

journal_title

Vaccine

authors

Both L,Banyard AC,van Dolleweerd C,Wright E,Ma JK,Fooks AR

doi

10.1016/j.vaccine.2013.01.025

subject

Has Abstract

pub_date

2013-03-15 00:00:00

pages

1553-9

issue

12

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(13)00082-0

journal_volume

31

pub_type

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