Deletion of the A35 gene from Modified Vaccinia Virus Ankara increases immunogenicity and isotype switching.

abstract：:The protection elicited by the intramuscular injection of two plasmid DNAs encoding Leishmania major cysteine proteinase type I (CPb) and type II (CPa) was evaluated in a murine model of experimental cutaneous leishmaniasis. BALB/c mice were immunized either separately or with a cocktail of the two plasmids expressing...

journal_title：Vaccine

authors： Rafati S,Salmanian AH,Taheri T,Vafa M,Fasel N

更新日期：2001-05-14 00:00:00

abstract：:After introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in the infant national immunization program (NIP) in the Netherlands in 2006, Streptococcus pneumoniae strains of the non-vaccine serotype 19A emerged and became the dominant serotype in carriage in children and their parents. Similar patterns we...

journal_title：Vaccine

authors： Bosch AATM,van Houten MA,Bruin JP,Wijmenga-Monsuur AJ,Trzciński K,Bogaert D,Rots NY,Sanders EAM

更新日期：2016-01-20 00:00:00

abstract：:Enterobactin (Ent)-mediated high affinity iron acquisition is critically important for Gram-negative bacterial pathogens to survive and infect the host. Recently, we reported an efficient method to prepare novel Ent conjugate vaccines for inducing high level of Ent-specific antibodies, which displayed similar bacterio...

journal_title：Vaccine

authors： Wang H,Zeng X,Lin J

更新日期：2020-11-17 00:00:00

abstract：:DNA-mediated immunizations have been used to raise neutralizing antibodies for measles virus. Single inoculations of plasmids expressing measles hemagglutinin or fusion glycoproteins raised neutralizing antibody in BALB/c mice. Plasmids expressing the hemagglutinin glycoprotein (both normal and secreted) raised neutra...

journal_title：Vaccine

authors： Yang K,Mustafa F,Valsamakis A,Santoro JC,Griffin DE,Robinson HL

更新日期：1997-06-01 00:00:00

abstract：INTRODUCTION:As congenital cytomegalovirus (CMV) infection is one of the major causes of birth defects and developmental abnormalities, it is essential to develop vaccines and therapeutic antibodies against CMV. Clinical trials demonstrated that the subunit vaccine based on glycoprotein B, which had been believed to be...

journal_title：Vaccine

authors： Kobayashi R,Abe M,Oguri K,Torikai M,Nishimura T,Mori H,Koshizuka T,Inoue N

更新日期：2018-09-25 00:00:00

abstract：:The immunity levels against diphtheria, tetanus and poliomyelitis were investigated among blood donors (n = 2079) in Berlin. Of all participants, only 60% had full, long-term protection against diphtheria, 72% against tetanus, 87% against poliomyelitis type 1, 77% against poliomyelitis type 2 and 73% against type 3. T...

journal_title：Vaccine

authors： Stark K,Schönfeld C,Barg J,Molz B,Vornwald A,Bienzle U

更新日期：1999-02-26 00:00:00

abstract：OBJECTIVE:To determine if the addition of a physician peer educator would lead to improved immunization quality when compared to the traditional education provided as part of a vaccines for children (VFC) site visit. METHODS:A randomized controlled trial was conducted. Study participants were private pediatric and fam...

journal_title：Vaccine

authors： Taylor JA,Rietberg K,Greenfield L,Bibus D,Yasuda K,Marcuse EK,Duchin JS

更新日期：2008-08-05 00:00:00

abstract：:Interleukin-5 (IL-5) is a cytokine which is essential for the maturation of eosinophils in bone marrow and for their release into the blood. Eotaxin is a CC type chemokine implicated in the recruitment of eosinophils in a variety of inflammatory disorders. Since eosinophil-activity is governed by these two pathways, w...

journal_title：Vaccine

authors： Zou Y,Sonderegger I,Lipowsky G,Jennings GT,Schmitz N,Landi M,Kopf M,Bachmann MF

更新日期：2010-04-19 00:00:00

abstract：:A recombinant ricin vaccine from E. coli (RVEc™), was developed at the US Army Medical Research Institute of Infectious Diseases (USAMRIID) and assessed in an FDA sponsored Phase 1a clinical trial. At the maximum dosage, two of the study participants developed physiological responses that were elevated to the level of...

journal_title：Vaccine

authors： Montgomery VA,Lindsey CY,Smith LA,Webb RP

更新日期：2021-01-15 00:00:00

abstract：:The efficacy of a vaccine is based primarily on the adherence of the subject to the immunization schedule. This paper compares the compliance rates (CR) for the third dose of hepatitis B virus (HBV) vaccine given according to one of two vaccination schedules among subjects attending two sexually transmitted disease (S...

journal_title：Vaccine

authors： Dal-Ré R,González A,Ramirez V,Ballesteros J,del Romero J,Bru F

更新日期：1995-02-01 00:00:00

abstract：:Foot and Mouth Disease (FMD) is an acute disease caused by Foot and Mouth Disease Virus (FMDV) which causes important economy losses, this is why it is necessary to obtain a vaccine that stimulates a rapid and long-lasting protective immune response. Cliptox is a mineral microparticle that in earlier studies has shown...

journal_title：Vaccine

authors： Batista A,Quattrocchi V,Olivera V,Langellotti C,Pappalardo JS,Di Giacomo S,Mongini C,Portuondo D,Zamorano P

更新日期：2010-08-31 00:00:00

abstract：:As part of safety monitoring during a group B meningococcal disease vaccination campaign in New Zealand, we examined the possible excess risk of vaccine-associated simple febrile seizures (SFS). We conducted a cohort analysis using data from active hospital-based surveillance in the South Auckland area and a national ...

journal_title：Vaccine

authors： Stehr-Green P,Radke S,Kieft C,Galloway Y,McNicholas A,Reid S

更新日期：2008-02-06 00:00:00

abstract：:Effects of cholera toxin B subunits supplemented with 0.1% cholera toxin (CTB*) on systemic IgE antibody responses to ovalbumin (OVA) were examined in BDFI (H-2b/d), Balb/c (H-2d) and C3H (H-2k) mice given OVA intragastrically or intranasally. Two successive doses of OVA intragastrically administered to Balb/c and C3H...

journal_title：Vaccine

authors： Tamura S,Shoji Y,Hasiguchi K,Aizawa C,Kurata T

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Two conserved pneumococcal proteins, pneumolysin toxoid (dPly) and pneumococcal histidine triad protein D (PhtD), combined with 10 polysaccharide conjugates from the pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) in two investigational pneumococcal vaccine (PHiD-CV/dPl...

journal_title：Vaccine

authors： Odutola A,Ota MOC,Antonio M,Ogundare EO,Saidu Y,Owiafe PK,Worwui A,Idoko OT,Owolabi O,Kampmann B,Greenwood BM,Alderson M,Traskine M,Swinnen K,Verlant V,Dobbelaere K,Borys D

更新日期：2019-05-01 00:00:00

abstract：:This article presents the World Health Organization's (WHO) recommendations for pain mitigation at the time of vaccination from the WHO position paper on reducing pain at the time of vaccination: WHO position paper-September 2015, recently published in the Weekly Epidemiological Record [1]. This position paper summari...

journal_title：Vaccine

authors： WHO.

更新日期：2016-07-12 00:00:00

abstract：:Susceptible dairy cattle were immunized with attenuated, live calf-derived, in vitro-cultured or biologically cloned Babesia bovis, with non-viable exoantigens, or with recombinant rhoptry-associated protein 1 (rRAP1). Antibody response assessed by the indirect fluorescent assay (IFA) and by the growth inhibition acti...

journal_title：Vaccine

authors： Fish L,Leibovich B,Krigel Y,McElwain T,Shkap V

更新日期：2008-12-19 00:00:00

abstract：:The epidemiology of infection due to Haemophilus influenzae type b (Hib) varies in different groups of Australian and New Zealand children. In most populations the annual case attack rate is approximately 40-60 per 100,000 children under 5 years of age and epiglottitis accounts for a relatively high but variable propo...

journal_title：Vaccine

authors： Gilbert GL

更新日期：1991-06-01 00:00:00

abstract：:We have demonstrated that vaccination of turkeys with an unformulated DNA vaccine induces significant protection against Chlamydophila (Cp.) psittaci infections. Nevertheless, the immunogenicity of the DNA vaccine can still be improved by increasing translation and transfection efficiency. Therefore, the ompA codon wa...

journal_title：Vaccine

authors： Verminnen K,Beeckman DS,Sanders NN,De Smedt S,Vanrompay DC

更新日期：2010-04-19 00:00:00

abstract：:Ten prospective clinical trials conducted in elderly and high-risk adults have failed to show that pneumococcal vaccine prevents pneumococcal bacteraemia and all pneumonia. Several of these trials focused on unrepresentative populations and most had serious methodological problems. Few adequately considered sample siz...

journal_title：Vaccine

authors： Fedson DS,Liss C

更新日期：2004-02-25 00:00:00

abstract：:The vast majority of vaccines used throughout the world are supplied by the private sector. It is essential therefore that the industry is closely engaged in future policy developments at a national and international level and is able to respond to the changing needs and priorities that may be required to ensure the s...

journal_title：Vaccine

authors： Almond J,Medaglini D

更新日期：2017-01-20 00:00:00

abstract：:In a study to develop novel vaccination strategies against tuberculosis, we encapsulated DNA encoding Ag85B, MPT-64 and MPT-83 antigens mixed with dimethyldioctyldecyl ammonium bromide (DDA) into biodegradable poly(dl-lactide-co-glycolide, PLGA) microspheres. Scanning electron microscopy (SEM) analysis demonstrated a ...

journal_title：Vaccine

authors： Cai H,Hu XD,Yu DH,Li SX,Tian X,Zhu YX

更新日期：2005-07-14 00:00:00

abstract：:The physico-chemical characterization of NadADelta(351-405), a recombinant protein discovered by reverse vaccinology, component of a candidate vaccine against Neisseria meningitidis serotype B is presented. Analytical methods like mass spectrometry, electrophoresis, optical spectroscopy and SEC-MALLS have been applied...

journal_title：Vaccine

authors： Magagnoli C,Bardotti A,De Conciliis G,Galasso R,Tomei M,Campa C,Pennatini C,Cerchioni M,Fabbri B,Giannini S,Mattioli GL,Biolchi A,D'Ascenzi S,Helling F

更新日期：2009-03-26 00:00:00

abstract：INTRODUCTION:It is important to quickly identify parent beliefs, intentions, and behaviors toward childhood vaccination, especially parents of children 19 to 35 months. This paper describes parental immunization beliefs, intentions, and behaviors; assesses the relationships between beliefs and intentions regarding chil...

journal_title：Vaccine

authors： Boyle J,Berman L,Nowak GJ,Iachan R,Middleton D,Deng Y

更新日期：2020-02-28 00:00:00

abstract：:A placebo-controlled, double-blind study on the efficacy of a hepatitis A vaccine (SmithKline Beecham Biologicals) was started in a region of Chile in September 1990, using hepatitis B vaccine as control. A total of 260 healthy children, 6-15 years of age, negative for antibody to hepatitis A virus (anti-HAV), antibod...

journal_title：Vaccine

authors： Riedemann S,Reinhardt G,Frösner GG,Ibarra H,Moraleda L,Hering V,Siegel F,Toledo C,Leon J,Gonzalez JL

更新日期：1992-01-01 00:00:00

abstract：:Fish has a soluble form of TLR5 ortholog (TLR5S), which does not exist in mammals. We identified TLR5S from rainbow trout and named rtTLR5S, which was about 38% homologous to the extracellular domains of human (hu) and mouse TLR5. Adjuvancy of rtTLR5S to flagellin response by human TLR5 (huTLR5) was tested in this stu...

journal_title：Vaccine

authors： Tsujita T,Ishii A,Tsukada H,Matsumoto M,Che FS,Seya T

更新日期：2006-03-15 00:00:00

abstract：:A safety requirement for live vaccines is investigating possible shedding in recipients since the presence of replication competent vaccine in secretions could result in direct and indirect horizontal transmission. This is especially relevant for oral rabies vaccine baits that are deliberately distributed into the env...

journal_title：Vaccine

authors： Vos A,Freuling C,Ortmann S,Kretzschmar A,Mayer D,Schliephake A,Müller T

更新日期：2018-02-01 00:00:00

abstract：:The potency of genetic immunization observed in the mouse has demonstrated the utility of DNA vaccines to induce cell-mediated and humoral immune responses. However, it has been relatively difficult to generate comparable responses in non-rodent species. The use of molecular adjuvants may increase the magnitude of the...

journal_title：Vaccine

authors： Maue AC,Waters WR,Palmer MV,Nonnecke BJ,Minion FC,Brown WC,Norimine J,Foote MR,Scherer CF,Estes DM

更新日期：2007-06-11 00:00:00

abstract：BACKGROUND:It has been assumed that measles infection may be associated with persistent immune suppression and long-term excess mortality. However, few community studies of mortality after measles infection have been carried out. We examined long-term mortality for measles cases, sub-clinical measles cases, and uninfec...

journal_title：Vaccine

authors： Aaby P,Simondon F,Samb B,Cisse B,Jensen H,Lisse IM,Soumaré M,Whittle H

更新日期：2002-11-22 00:00:00

abstract：:We have previously shown that vaccination of BALB/c mice with a combination of BCG plus killed Leishmania promastigotes, applied by the i.p. route 10 and 3 days before Trypanosoma cruzi inoculation, prolonged their survival and decreased their parasitaemia. In the present study we show that the BCG-Leishmania vaccine ...

journal_title：Vaccine

authors： Araujo Z,Heremans H,Stordeur P,Wissing M,Goldman M,Castes M,Carlier Y

更新日期：2000-03-06 00:00:00

abstract：:Measles incidence has decreased dramatically in China due to the implement of measles-containing vaccine (MCV). However, a measles epidemic caused resurgence recently, even among vaccinated individuals. To evaluate the effectiveness of current immunization programs and discuss initiatives for the next step in measles ...

journal_title：Vaccine

authors： Cui A,Zhang Y,Zhu Z,Wang H,Mao N,Song J,Xu W

更新日期：2020-05-08 00:00:00