Deletion of the A35 gene from Modified Vaccinia Virus Ankara increases immunogenicity and isotype switching.

Abstract:

:We show here that the immunogenicity of the Modified Vaccinia Ankara MVA vaccine strain can be improved by deletion of the A35 gene, without diminishing the ability of the virus to replicate. Deletion of the A35 gene resulted in increased virus-specific immunoglobulin production, class switching to IgG isotypes, and virus-specific IFNγ-secreting splenocytes. The MVA35 deletion virus provided excellent protective efficacy against virulent virus challenge. These results suggest that A35 deletion mutant strains will have superior vaccine performance for poxvirus vaccines as well as platform vaccines for other infectious diseases and cancer.

journal_name

Vaccine

journal_title

Vaccine

authors

Rehm KE,Roper RL

doi

10.1016/j.vaccine.2011.02.023

subject

Has Abstract

pub_date

2011-04-12 00:00:00

pages

3276-83

issue

17

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(11)00236-2

journal_volume

29

pub_type

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