Abstract:
BACKGROUND:In January 2015, Tajikistan introduced the monovalent rotavirus vaccine into the national immunization program. Our objective was to estimate pre-vaccine burden of rotavirus-associated hospitalizations in children <5 years of age in Tajikistan. METHODS:During January 2013-December 2014, active surveillance for acute gastroenteritis (AGE)-associated hospitalizations in children <5 years of age was conducted by sentinel surveillance site staff. Patients' demographic and clinical data were summarized and a stool sample was collected. An Enzyme Linked Immunosorbent Assay was used for diagnosis of rotavirus infection and subset of the specimens was sent for polymerase chain reaction (PCR) genotyping. RESULTS:Of 2860 eligible children enrolled and tested, 1207 (42%) were positive for rotavirus. An increase in the number and proportion of rotavirus cases attributed to rotavirus season, with positivity rates >40%, was annually observed during June-September. The median age of rotavirus patients was 9 months and 939/1207 (78%) rotavirus patients were aged 6-23 months. Most (1097/1203; 91%) rotavirus patients were treated with intravenous fluids. G1P[8] was the predominant genotype during both years of surveillance, accounting for 133/222 (60%) of genotyped cases. CONCLUSION:Rotavirus is a major cause of hospitalization due to severe AGE in children <5 years of age in Tajikistan, accounting for >40% of cases. Continued, enhanced rotavirus surveillance may allow documentation of changes in rotavirus disease burden following vaccine introduction and assessment of vaccine effectiveness.
journal_name
Vaccinejournal_title
Vaccineauthors
Nazurdinov AB,Azizov ZA,Tishkova F,Turkov SM,Daniels DS,Leshem Edoi
10.1016/j.vaccine.2017.08.031subject
Has Abstractpub_date
2018-12-14 00:00:00pages
7794-7797issue
51eissn
0264-410Xissn
1873-2518pii
S0264-410X(17)31115-5journal_volume
36pub_type
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