Preparation and evaluation of Vero-cell infectious bursal disease vaccine in Pakistan.

abstract：INTRODUCTION:Despite the enormous benefits of childhood and maternal immunisation to individual and population health, the uptake of maternal vaccines during pregnancy remains suboptimal. Midwives are a trusted information source for parents and play an important role in the provision of immunisation information. Under...

journal_title：Vaccine

authors： Frawley JE,McKenzie K,Sinclair L,Cummins A,Wardle J,Hall H

更新日期：2020-01-10 00:00:00

abstract：:Pertussis vaccine development has mainly focused on Bordetella pertussis, and consequently these vaccines contain B. pertussis antigens only. However, the related species Bordetella parapertussis can also cause pertussis, although symptoms associated with the disease are generally considered to be milder. Recent field...

journal_title：Vaccine

authors： David S,van Furth R,Mooi FR

更新日期：2004-05-07 00:00:00

abstract：:Two cyclic peptide analogues corresponding to residues 139-146 (site A) of influenza A virus haemagglutinin (strain X31) were synthesized. The ability of these peptides to react with anti-influenza virus antibodies was found to depend on the conformation of the loop and on the orientation in which the peptide was pres...

journal_title：Vaccine

authors： Muller S,Plaué S,Samama JP,Valette M,Briand JP,Van Regenmortel MH

更新日期：1990-08-01 00:00:00

abstract：:The compatibility, safety and interaction on antibody induction of a combined vaccine application were assessed. Specific pathogen-free cats were vaccinated with either a modified live virus vaccine containing feline calici- (FCV), herpes- (FHV-1), parvovirus (FPV) and Chlamydophila felis (C. felis), an adjuvanted rec...

journal_title：Vaccine

authors： Brunner C,Kanellos T,Meli ML,Sutton DJ,Gisler R,Gomes-Keller MA,Hofmann-Lehmann R,Lutz H

更新日期：2006-03-10 00:00:00

abstract：BACKGROUND:It has been assumed that measles infection may be associated with persistent immune suppression and long-term excess mortality. However, few community studies of mortality after measles infection have been carried out. We examined long-term mortality for measles cases, sub-clinical measles cases, and uninfec...

journal_title：Vaccine

authors： Aaby P,Simondon F,Samb B,Cisse B,Jensen H,Lisse IM,Soumaré M,Whittle H

更新日期：2002-11-22 00:00:00

abstract：:Influenza H3N2 viruses have recently drifted from A/Wisconsin/67/05-like to A/Brisbane/10/07-like viruses. The effect of key amino acid substitutions in the hemagglutinin (HA) protein on the replication, antigenicity and immunogenicity of cold-adapted, live attenuated vaccine strains was examined. A/Brisbane/10/07 egg...

journal_title：Vaccine

authors： Chen Z,Zhou H,Jin H

更新日期：2010-05-28 00:00:00

abstract：:The treatment effect against psoriasis of an antigen (delipidated, deglycolipidated form of M. vaccae-PVAC) was investigated. One hundred and sixty-five patients were enrolled in three arms (50 or 15 microg or placebo), each receiving a total of two intradermal injections (days 0 and 21). At week 12, a 75% decrease in...

journal_title：Vaccine

authors： Netto EM,Takahashi D,de Fátima Paim de Oliveira M,Barbosa P,Ferraz N,Paixão A,Oyafuso LK,Bortoletto C,Matos D,Paixão M,da Silva AO,Badaro R

更新日期：2006-06-05 00:00:00

abstract：:Improving the ability of DNA-based vaccines to induce potent Type1/Th1 responses against intracellular pathogens in large outbred species is essential. Rhodoccocus equi and equine infectious anemia virus (EIAV) are two naturally occurring equine pathogens that also serve as important large animal models of neonatal im...

journal_title：Vaccine

authors： Mealey RH,Stone DM,Hines MT,Alperin DC,Littke MH,Leib SR,Leach SE,Hines SA

更新日期：2007-10-23 00:00:00

abstract：:The objectives of this study were to evaluate the effects of a therapeutic vaccine intervention with a modified-live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine on the dynamics of a heterologous viral infection in a population of pigs, and to determine the clinical and virological response of p...

journal_title：Vaccine

authors： Cano JP,Dee SA,Murtaugh MP,Pijoan C

更新日期：2007-05-30 00:00:00

abstract：:Vaccine adjuvants are essential for enhancing immune responses during vaccination. However, only a limited number of safe and effective adjuvants, especially mucosal adjuvants, are available for use in vaccines. The development of a practically applicable mucosal adjuvant is therefore urgently needed. Here, we showed ...

journal_title：Vaccine

authors： Fan X,Su Q,Qiu F,Yi Y,Shen L,Jia Z,Liang P,Zou Y,Bi S

更新日期：2018-07-05 00:00:00

abstract：:By using a baculovirus expression system, we have successfully produced simian immunodeficiency virus (SIV)-like particles (VLPs) with high levels of biologically active SIV envelope (Env) incorporated on their surfaces. To study whether SIV VLPs represent effective mucosal immunogens, we immunized groups of mice with...

journal_title：Vaccine

authors： Yao Q,Vuong V,Li M,Compans RW

更新日期：2002-06-07 00:00:00

abstract：BACKGROUND:New, more effective vaccines to prevent tuberculosis (TB) disease are needed urgently. H4:IC31 is an investigational vaccine that contains a fusion protein of the immunodominant antigens TB10.4 and Ag85B, formulated in IC31 adjuvant. We assessed the safety and immunogenicity of H4:IC31 in South African adult...

journal_title：Vaccine

authors： Geldenhuys H,Mearns H,Miles DJ,Tameris M,Hokey D,Shi Z,Bennett S,Andersen P,Kromann I,Hoff ST,Hanekom WA,Mahomed H,Hatherill M,Scriba TJ,H4:IC31 Trial Study Group.,van Rooyen M,Bruce McClain J,Ryall R,de Bruyn G,H4:

更新日期：2015-07-09 00:00:00

abstract：:WHO is now celebrating more than 30 years of freedom from smallpox. What was originally seen as a victory over an ancient scourge can now be viewed as an epidemiologically driven programme to overcome governmental inertia and under-achievement in delivering an off-patent vaccine. Though efforts are accelerating global...

journal_title：Vaccine

authors： Music S

更新日期：2010-01-22 00:00:00

abstract：OBJECTIVES:We aimed to estimate vaccine effectiveness against severe measles based on the number of vaccine doses administered and the time since last vaccination. PATIENTS AND METHODS:We included measles cases aged at least 2 years and born since 1980 who were notified in France between 2006 and mid-2019. We consider...

journal_title：Vaccine

authors： Bonneton M,Antona D,Danis K,Aït-Belghiti F,Levy-Bruhl D

更新日期：2020-06-15 00:00:00

abstract：:The carboxyl-terminal region of the merozoite surface protein-1 (MSP1) is a leading candidate for a vaccine against malaria in the erythrocytic stage. In this study, we investigated the utility of interleukin-12 (IL-12) cDNA as an adjuvant for malaria DNA vaccine in a mouse challenge model. We found that co-immunizati...

journal_title：Vaccine

authors： Sakai T,Hisaeda H,Nakano Y,Zhang M,Takashima M,Ishii K,Maekawa Y,Matsumoto S,Nitta Y,Miyazaki Ji,Yamamoto S,Himeno K

更新日期：2003-03-28 00:00:00

abstract：:Humoral responses against extra-cellular HIV-1 Tat may be beneficial as Tat has been implicated in the viral pathogenesis associated with HIV-1 disease progression. We determined the levels of anti-Tat IgG in sera of HIV-1 seropositive individuals from the Rural Clinical Cohort in Uganda using nine different Tat prote...

journal_title：Vaccine

authors： Campbell GR,Senkaali D,Watkins J,Esquieu D,Opi S,Yirrell DL,Kaleebu P,Loret EP

更新日期：2007-12-05 00:00:00

abstract：BACKGROUND:Recent guidance from related regulatory agencies and medical societies supports mandatory vaccination of healthcare workers (HCW) against influenza. At St. Jude Children's Research Hospital, a pediatric oncology referral center, more than 90% of HCWs receive vaccine each year without a policy mandating immun...

journal_title：Vaccine

authors： Hakim H,Gaur AH,McCullers JA

更新日期：2011-08-11 00:00:00

abstract：OBJECTIVE:Despite recommendations by professional organizations that all pregnant women receive inactivated influenza vaccine, safety concerns remain a barrier. Our objective was to assess the effect of trivalent influenza vaccines (IIV3) during pregnancy on parent report 6-month infant development. METHODS:We conduct...

journal_title：Vaccine

authors： Avalos LA,Ferber J,Zerbo O,Naleway AL,Bulkley J,Thompson M,Cragan J,Williams J,Odouli R,Kauffman TL,Ball S,Shifflett P,Li DK

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:Gram-negative bacteria (GNB) are a leading cause of nosocomial infection and sepsis. Increasing multi-antibiotic resistance has left clinicians with fewer therapeutic options. Antibodies to GNB lipopolysaccharide (LPS, or endotoxin) have reduced morbidity and mortality as a result of infection and are not su...

journal_title：Vaccine

authors： Cross AS,Greenberg N,Billington M,Zhang L,DeFilippi C,May RC,Bajwa KK

更新日期：2015-11-27 00:00:00

abstract：:H5N1, highly pathogenic avian influenza poses, a threat to animal and human health. Rapid changes in H5N1 viruses require periodic reformulation of the conventional strain-matched vaccines, thus emphasizing the need for a broadly protective influenza vaccine. Here, we constructed BV-Dual-3M2e-LTB, a recombinant baculo...

journal_title：Vaccine

authors： Zhang J,Fan HY,Zhang Z,Zhang J,Zhang J,Huang JN,Ye Y,Liao M

更新日期：2016-01-27 00:00:00

abstract：:Staphylococcus aureus is a major human pathogen and many of the strains are resistant to conventional antibacterial treatment. The bacteria cause disease largely due to the production of multiple toxins, whose synthesis is controlled by an RNA molecule termed RNAIII. The production of RNAIII is induced by quorum sensi...

journal_title：Vaccine

authors： Yang G,Gao Y,Dong J,Xue Y,Fan M,Shen B,Liu C,Shao N

更新日期：2006-02-20 00:00:00

abstract：BACKGROUND:The Polio Endgame strategy includes phased withdrawal of oral poliovirus vaccines (OPV) coordinated with introduction of inactivated poliovirus vaccine (IPV) to ensure population immunity. The impact of IPV introduction into a primary OPV series of immunizations in a developing country is uncertain. METHODS...

journal_title：Vaccine

authors： Mychaleckyj JC,Haque R,Carmolli M,Zhang D,Colgate ER,Nayak U,Taniuchi M,Dickson D,Weldon WC,Oberste MS,Zaman K,Houpt ER,Alam M,Kirkpatrick BD,Petri WA Jr

更新日期：2016-01-12 00:00:00

abstract：:DNA vaccination is a promising alternative strategy for developing new human and animal vaccines. The massive efforts made these past 25 years to increase the immunizing potential of this kind of vaccine are still ongoing. A relatively small number of studies concerning poultry have been published. Even though there i...

journal_title：Vaccine

authors： Meunier M,Chemaly M,Dory D

更新日期：2016-01-04 00:00:00

abstract：:Visceral leishmaniasis, caused by the intracellular parasite Leishmania donovani is a significant public health problem in many regions of the world. Anti-leishmanial immune defences are primarily dependent on the ability of the host to mount an interleukin-12 (IL-12) driven Th1 type of responses. Thus, IL-12 plays a ...

journal_title：Vaccine

authors： Tewary P,Saxena S,Madhubala R

更新日期：2006-03-20 00:00:00

abstract：:In a previous work we selected montanide ISA720 (M-ISA720) among different adjuvants for the vaccination with a V3 loop based multi-epitope polypeptide TAB9. In this paper we present the evaluation of the toxicity and immunogenicity of this formulation in non-human primates. TAB9 in M-ISA720 was highly immunogenic in ...

journal_title：Vaccine

authors： Gómez CE,Navea L,Lobaina L,Dubed M,Expósito N,Soto A,Duarte CA

更新日期：1999-05-04 00:00:00

abstract：:The use of pneumococcal polysaccharide vaccine (PPV) is low in some countries, maybe because of doubts regarding its efficacy. This meta-analysis aims at combining evidence from randomized trials of PPV assessing its efficacy in preventing Streptococcus pneumoniae related diseases in immunocompetent adults. In the fou...

journal_title：Vaccine

authors： Cornu C,Yzèbe D,Léophonte P,Gaillat J,Boissel JP,Cucherat M

更新日期：2001-09-14 00:00:00

abstract：:Immune responses to the infectious bronchitis virus (IBV) nucleocapsid protein were studied using a recombinant-DNA expression product. In mice, a lymphocyte proliferative response and a delayed-type hypersensitivity reaction to IBV were induced upon immunization with this nucleocapsid protein. Next, we studied the ro...

journal_title：Vaccine

authors： Boots AM,Benaissa-Trouw BJ,Hesselink W,Rijke E,Schrier C,Hensen EJ

更新日期：1992-01-01 00:00:00

abstract：:Vaccination with plasmid DNA against infectious pathogens including dengue is an active area of investigation. By design, DNA vaccines are able to elicit both antibody responses and cellular immune responses capable of mediating long-term protection. Great technical improvements have been made in dengue DNA vaccine co...

journal_title：Vaccine

authors： Danko JR,Beckett CG,Porter KR

更新日期：2011-09-23 00:00:00

abstract：:Salmonella strains have great potential as live carriers of heterologous antigens to induce immunity against a variety of infectious diseases. However, the amount of heterologous antigen required to induce an adequate immune response may be toxic for the bacterium and result in cell death, overattenuation or loss of e...

journal_title：Vaccine

authors： Tijhaar EJ,Zheng-Xin Y,Karlas JA,Meyer TF,Stukart MJ,Osterhaus AD,Mooi FR

更新日期：1994-08-01 00:00:00

abstract：:A major impediment to the development of peptide vaccines has been the inability accurately to mimic conformationally constrained epitopes on the envelope proteins of pathogens. This limitation is further compounded by the fact that several viral envelope proteins exist either as covalently or non-covalently associate...

journal_title：Vaccine

authors： Rao KV,Panda SK,Manivel V

更新日期：1992-01-01 00:00:00