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Protective effect of PCV vaccine against experimental pneumococcal challenge in adults is primarily mediated by controlling colonisation density.

Abstract：

:Widespread use of Pneumococcal Conjugate Vaccines (PCV) has reduced vaccine-type nasopharyngeal colonisation and invasive pneumococcal disease. In a double-blind, randomised controlled trial using the Experimental Human Pneumococcal Challenge (EHPC) model, PCV-13 (Prevenar-13) conferred 78% protection against colonisation acquisition and reduced bacterial intensity (AUC) as measured by classical culture. We used a multiplex qPCR assay targeting lytA and pneumococcal serotype 6A/B cpsA genes to re-assess the colonisation status of the same volunteers. Increase in detection of low-density colonisation resulted in reduced PCV efficacy against colonisation acquisition (29%), compared to classical culture (83%). For experimentally colonised volunteers, PCV had a pronounced effect on decreasing colonisation density. These results obtained in adults suggest that the success of PCV vaccination could primarily be mediated by the control of colonisation density. Studies assessing the impact of pneumococcal vaccines should allow for density measurements in their design.

journal_name

Vaccine

journal_title

Vaccine

authors

German EL,Solórzano C,Sunny S,Dunne F,Gritzfeld JF,Mitsi E,Nikolaou E,Hyder-Wright AD,Collins AM,Gordon SB,Ferreira DM

doi

10.1016/j.vaccine.2019.05.080

subject

Has Abstract

pub_date

2019-07-09 00:00:00

pages

3953-3956

issue

30

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(19)30717-0

journal_volume

37

pub_type

杂志文章,随机对照试验

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