Brief education to promote maternal influenza vaccine uptake: A randomized controlled trial.


BACKGROUND:Although pregnant women are the highest priority group for seasonal influenza vaccination, maternal influenza vaccination rates remain suboptimal. The purpose of this study was to evaluate the effect of a brief education intervention on maternal influenza vaccine uptake. METHODS:During the 2013-14 and 2014-15 influenza seasons, we recruited 321 pregnant women from the antenatal clinics of 4 out of 8 public hospitals in Hong Kong with obstetric services. Hospitals were geographically dispersed and provided services to pregnant women with variable socioeconomic backgrounds. Participants were randomized to receive either standard antenatal care or brief one-to-one education. Participants received telephone follow-up at 2 weeks postpartum. The primary study outcome was self-reported receipt of influenza vaccination during pregnancy. The secondary outcomes were the proportion of participants who initiated discussion about influenza vaccination with a health care professional and the proportion of participants who attempted to get vaccinated. RESULTS:Compared with participants who received standard care, the vaccination rate was higher among participants who received brief education (21.1% vs. 10%; p=0.006). More participants in the education group initiated discussion about influenza vaccination with their HCP (19.9% vs. 13.1%; p=0.10), but the difference was not statistically significant. Of participants who did not receive the influenza vaccine (n=271), 45 attempted to get vaccinated. A significantly higher proportion of participants who attempted to get vaccinated were in the intervention group (82.2% vs. 17.8%; p<0.001). If participants who had attempted vaccination had received the vaccine, vaccination rates would have been substantially higher (44.1% vs. 15%; p<0.001). Twenty-six participants were advised against influenza vaccination by a healthcare professional, including general practitioners, obstetricians, and nurses. CONCLUSION:Although brief education was effective in improving vaccination uptake among pregnant women, overall vaccination rates remain suboptimal. Multicomponent approaches, including positive vaccination recommendations by healthcare professionals, are needed to promote maternal influenza vaccination. CLINICAL TRIAL (NCT01772901).






Wong VWY,Fong DYT,Lok KYW,Wong JYH,Sing C,Choi AY,Yuen CYS,Tarrant M




Has Abstract


2016-10-17 00:00:00
















  • Booster response to recombinant yeast-derived hepatitis B vaccine in vaccinees whose anti-HBs responses were initially elicited by a plasma-derived vaccine.

    abstract::One hundred and eight primary school students who had been vaccinated with three doses of a plasma-derived hepatitis B vaccine were randomly divided into two groups, to receive a booster dose of either the same vaccine or of a recombinant yeast-derived vaccine. The pre-booster anti-hepatitis B surface antigen (HBs) ge...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Chan CY,Lee SD,Tsai YT,Lo KJ

    更新日期:1991-10-01 00:00:00

  • Impact of postpartum information about pertussis booster to parents in a university maternity hospital.

    abstract::Parent-to-infant transmission of pertussis remains an issue in France. Although adult booster vaccination was introduced in 2004 as part of a cocooning strategy targeted primarily to parents of young infants, vaccination coverage in this population has remained low. The aim of this study was to evaluate the impact on ...


    pub_type: 杂志文章


    authors: Leboucher B,Sentilhes L,Abbou F,Henry E,Grimprel E,Descamps P

    更新日期:2012-08-10 00:00:00

  • Antibodies to measles, mumps and rubella in UK children 4 years after vaccination with different MMR vaccines.

    abstract::Persistence of antibodies 4 years after vaccination with measles, mumps and rubella (MMR) vaccine from three different manufacturers was compared in 475 children who received a single injection of vaccine when aged 12-18 months. Antibodies to measles and mumps were measured using a plaque reduction neutralisation assa...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Miller E,Hill A,Morgan-Capner P,Forsey T,Rush M

    更新日期:1995-06-01 00:00:00

  • Modelling the effect of discontinuing universal Bacillus Calmette-Guérin vaccination in an intermediate tuberculosis burden setting.

    abstract:BACKGROUND:Bacillus Calmette-Guérin (BCG) vaccination is a widely-used public health intervention for tuberculosis (TB) control. In Taiwan, like other intermediate TB burden settings, steadily declining TB incidence raises important questions on whether universal BCG vaccination should be discontinued. Recent surveys o...


    pub_type: 杂志文章


    authors: Fu H,Lin HH,Hallett TB,Arinaminpathy N

    更新日期:2018-09-18 00:00:00

  • Mucosal immunization with experimental feline immunodeficiency virus (FIV) vaccines induces both antibody and T cell responses but does not protect against rectal FIV challenge.

    abstract::Feline immunodeficiency virus (FIV) is a natural lentiviral pathogen of cats which can be experimentally transmitted via rectal and vaginal routes--the major routes of human immunodeficiency virus type 1 transmission in man. An important objective for lentiviral research is the development of vaccine strategies which ...


    pub_type: 杂志文章


    authors: Finerty S,Stokes CR,Gruffydd-Jones TJ,Hillman TJ,Reeves NA,Whiting CV,Schaaper WM,Dalsgaard K,Harbour DA

    更新日期:2000-08-01 00:00:00

  • Immunosuppressive drugs impairs antibody response of the polysaccharide and conjugated pneumococcal vaccines in patients with Crohn's disease.

    abstract:BACKGROUND:Patients with Crohn's disease (CD) have a higher risk of infectious diseases including pneumococcal infections, and the risk increases with immunotherapy. The primary endpoint of this study was to investigate the specific antibody response to two pneumococcal vaccines in CD patients with and without immunosu...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kantsø B,Halkjær SI,Thomsen OØ,Belard E,Gottschalck IB,Jørgensen CS,Krogfelt KA,Slotved HC,Ingels H,Petersen AM

    更新日期:2015-10-05 00:00:00

  • Impact of influenza vaccination on mortality in the French elderly population during the 2000-2009 period.

    abstract::With declining influenza vaccine coverage in the elderly in recent years in France, we aimed at assessing the benefits of seasonal influenza vaccination, based on available data for observed mortality, vaccine coverage and vaccine effectiveness. To estimate the annual number of deaths avoided by vaccination in the peo...


    pub_type: 杂志文章


    authors: Bonmarin I,Belchior E,Lévy-Bruhl D

    更新日期:2015-02-25 00:00:00

  • Levels of antibodies specific to diphtheria toxoid, tetanus toxoid, and Haemophilus influenzae type b in healthy children born to Tdap-vaccinated mothers.

    abstract:INTRODUCTION:Vaccination of pregnant women protects both women and their newborns against some infectious diseases. Thailand implemented tetanus toxoid (TT) vaccination of pregnant women in 1977, which was replaced by tetanus-diphtheria toxoid (dT) vaccination in 2005. The tetanus-diphtheria-acellular pertussis (Tdap) ...


    pub_type: 杂志文章


    authors: Wanlapakorn N,Maertens K,Thongmee T,Srimuan D,Thatsanathorn T,Van Damme P,Leuridan E,Poovorawan Y

    更新日期:2020-10-14 00:00:00

  • Immunogenicity and safety of tetravalent dengue vaccine in 2-11 year-olds previously vaccinated against yellow fever: randomized, controlled, phase II study in Piura, Peru.

    abstract::In a randomized, placebo-controlled, monocenter, observer blinded study conducted in an area where dengue is endemic, we assessed the safety and immunogenicity of a recombinant, live, attenuated, tetravalent dengue vaccine candidate (CYD-TDV) in 2-11 year-olds with varying levels of pre-existing yellow-fever immunity ...


    pub_type: 杂志文章,随机对照试验


    authors: Lanata CF,Andrade T,Gil AI,Terrones C,Valladolid O,Zambrano B,Saville M,Crevat D

    更新日期:2012-09-07 00:00:00

  • Establishment of gene-vaccinated skin grafting against Toxoplasma gondii infection in mice.

    abstract::Vaccine effects of in vivo gene-vaccinated skin graft were evaluated against Toxoplasma gondii (T. gondii) infection. By using a gene gun, cDNA coding T. gondii SAG1 molecule was intracutaneously vaccinated into C57BL/6 (B6; a susceptible strain), BALB/c (a resistant strain) and (C57BL/6 x BALB/c) F1 (CBF1) mice, and ...


    pub_type: 杂志文章


    authors: Saito S,Aosai F,Rikihisa N,Mun HS,Norose K,Chen M,Kuroki T,Asano T,Ochiai T,Hata H,Ichinose M,Yano A

    更新日期:2001-02-28 00:00:00

  • Sero-epidemiology of measles and mumps in Korea: impact of the catch-up campaign on measles immunity.

    abstract::A catch-up campaign targeting children aged 8-16 years using measles-rubella (MR) vaccine was conducted during 2001 in Korea. To evaluate the impact of the campaign and assess mumps immunity, human IgG antibodies were detected using ELISA for measles (5826 samples) and mumps (5890 samples) in a national sample of oppo...


    pub_type: 杂志文章,多中心研究


    authors: Kim SS,Han HW,Go U,Chung HW

    更新日期:2004-12-02 00:00:00

  • Effect of adjuvants and route of immunizations on the immune response to recombinant plague antigens.

    abstract::In this study, we compare four different adjuvants, LT(R192G), CpG ODN, MPL((R))TDM, and alum, for their ability to affect the magnitude, distribution, and duration of antibody responses against F1-V, the lead-candidate antigen for the next generation vaccine against plague, in a murine model. In addition, three diffe...


    pub_type: 杂志文章


    authors: Uddowla S,Freytag LC,Clements JD

    更新日期:2007-11-19 00:00:00

  • Immunogenicity, safety, biodistribution and persistence of ADVAX, a prophylactic DNA vaccine for HIV-1, delivered by in vivo electroporation.

    abstract::ADVAX is a DNA-based candidate HIV vaccine that was safe but weakly immunogenic when delivered intramuscularly (IM) in humans. Studies were performed in animal models to determine whether an alternative delivery method, in vivo electroporation (EP), could improve the immunogenicity of ADVAX while maintaining an accept...


    pub_type: 杂志文章


    authors: Dolter KE,Evans CF,Ellefsen B,Song J,Boente-Carrera M,Vittorino R,Rosenberg TJ,Hannaman D,Vasan S

    更新日期:2011-01-17 00:00:00

  • SIV vaccines: current status. The role of the SIV-macaque model in AIDS research.

    abstract::SIV vaccines made of inactivated whole virus, modified live virus and native and recombinant envelope antigens have protected macaques against experimental infection with low doses of cell-free SIV given systemically. The few vaccinated monkeys that do become infected have tended to live longer than the infected contr...


    pub_type: 杂志文章,评审


    authors: Gardner M

    更新日期:1991-11-01 00:00:00

  • Induction of anti-viral immune responses by immunization with recombinant-DNA encoded avian coronavirus nucleocapsid protein.

    abstract::Immune responses to the infectious bronchitis virus (IBV) nucleocapsid protein were studied using a recombinant-DNA expression product. In mice, a lymphocyte proliferative response and a delayed-type hypersensitivity reaction to IBV were induced upon immunization with this nucleocapsid protein. Next, we studied the ro...


    pub_type: 杂志文章


    authors: Boots AM,Benaissa-Trouw BJ,Hesselink W,Rijke E,Schrier C,Hensen EJ

    更新日期:1992-01-01 00:00:00

  • DNA vaccine with α-galactosylceramide at prime phase enhances anti-tumor immunity after boosting with antigen-expressing dendritic cells.

    abstract::DNA vaccines contribute to a promising new approach for the generation of cytotoxic T lymphocytes (CTL). DNA vaccines do have several disadvantages, including poor immunogenicity and oncogene expression. We used the natural killer T-cell (NKT) ligand α-galactosylceramide (α-GalCer) as an adjuvant to prime initial DNA ...


    pub_type: 杂志文章


    authors: Kim D,Hung CF,Wu TC,Park YM

    更新日期:2010-10-21 00:00:00

  • Review of prescribing information for influenza vaccines for pregnant and lactating women.

    abstract::Information provided by most influenza vaccine manufacturers do not reflect the recommendations of WHO and/or national public health advisory groups with regard to the use of influenza vaccines in pregnant or lactating women. The majority of vaccines contain precautionary language which could discourage use in pregnan...


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    authors: Proveaux T,Lambach P,Ortiz JR,Hombach J,Halsey NA

    更新日期:2016-10-26 00:00:00

  • Combination vaccines in the South African setting.

    abstract::The number of vaccines available and included as part of the national immunization schedules, has increased significantly over the past few decades. This impacts on patient/parent compliance and creates a challenge for health care providers for implementation of schedules necessitating training and infrastructure impr...


    pub_type: 杂志文章,评审


    authors: Visser A,Hoosen A

    更新日期:2012-09-07 00:00:00

  • Comparison of immune responses generated by optimized DNA vaccination against SIV antigens in mice and macaques.

    abstract::Optimized DNA vectors were constructed comprising the proteome of SIV including the structural, enzymatic, regulatory, and accessory proteins. In addition to native antigens as produced by the virus, fusion proteins and modified antigens with altered secretion, cellular localization and stability characteristics were ...


    pub_type: 杂志文章


    authors: Kulkarni V,Jalah R,Ganneru B,Bergamaschi C,Alicea C,von Gegerfelt A,Patel V,Zhang GM,Chowdhury B,Broderick KE,Sardesai NY,Valentin A,Rosati M,Felber BK,Pavlakis GN

    更新日期:2011-09-09 00:00:00

  • Foot-and-mouth disease vaccine potency testing in cattle using homologous and heterologous challenge strains: precision of the "Protection against Podal Generalisation" test.

    abstract::The level of protection conferred by foot-and-mouth disease (FMD) vaccines in primovaccinated animals primarily depends on the potency of the vaccine and the relatedness of the vaccine strain and circulating field isolate. The "Gold Standard" FMD vaccine potency test is the in vivo test performed in the target species...


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    authors: Goris N,Maradei E,D'Aloia R,Fondevila N,Mattion N,Perez A,Smitsaart E,Nauwynck HJ,La Torre J,Palma E,De Clercq K

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  • Influenza vaccine effectiveness in preventing influenza-associated intensive care admissions and attenuating severe disease among adults in New Zealand 2012-2015.

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    authors: Thompson MG,Pierse N,Sue Huang Q,Prasad N,Duque J,Claire Newbern E,Baker MG,Turner N,McArthur C,SHIVERS investigation team.

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  • A national examination of pharmacy-based immunization statutes and their association with influenza vaccinations and preventive health.

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    authors: McConeghy KW,Wing C

    更新日期:2016-06-24 00:00:00

  • Low uptake of influenza vaccine among university students: evaluating predictors beyond cost and safety concerns.

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    pub_type: 杂志文章


    authors: Bednarczyk RA,Chu SL,Sickler H,Shaw J,Nadeau JA,McNutt LA

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    authors: Yang YT,Shaw J

    更新日期:2018-01-29 00:00:00

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    authors: Ayrle H,Mevissen M,Kaske M,Vögtlin A,Fricker R,Hoffmann B,Büttner M,Marinovic Z,Walkenhorst M

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    pub_type: 杂志文章,评审


    authors: King C,Beard J,Crampin AC,Costello A,Mwansambo C,Cunliffe NA,Heyderman RS,French N,Bar-Zeev N,VacSurv Consortium.

    更新日期:2015-09-11 00:00:00

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    abstract::A vaccine based upon a recombinant plant virus (CPMV-PARVO1), displaying a peptide derived from the VP2 capsid protein of canine parvovirus (CPV), has previously been described. To date, studies with the vaccine have utilized viable plant chimaeric particles (CVPs). In this study, CPMV-PARVO1 was inactivated by UV tre...


    pub_type: 杂志文章


    authors: Langeveld JP,Brennan FR,Martínez-Torrecuadrada JL,Jones TD,Boshuizen RS,Vela C,Casal JI,Kamstrup S,Dalsgaard K,Meloen RH,Bendig MM,Hamilton WD

    更新日期:2001-06-14 00:00:00

  • Intranasal inoculate of influenza virus vaccine against lethal virus challenge.

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    pub_type: 杂志文章


    authors: Fan X,Su Q,Qiu F,Yi Y,Shen L,Jia Z,Liang P,Zou Y,Bi S

    更新日期:2018-07-05 00:00:00

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    pub_type: 杂志文章


    authors: Corbeil S,Seguin C,Trudel M

    更新日期:1996-04-01 00:00:00

  • Induction of autoantibody production but not autoimmune disease in HEL transgenic mice vaccinated with HEL in combination with CpG or control oligodeoxynucleotides.

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    pub_type: 杂志文章


    authors: Wang Y,Krieg AM

    更新日期:2004-06-30 00:00:00