Abstract:
:Since 1999, Italy has been challenged by several epidemics of Notifiable Avian Influenza (NAI) of the H5 and H7 subtypes, occurring in the densely populated poultry areas of northern part of the country. Vaccination with a conventional vaccine containing a seed strain with a different neuraminidase subtype to the field virus was used to complement biosecurity and restriction measures as part of an overall eradication strategy. This vaccination technique, known as the "DIVA-Differentiating Infected from Vaccinated Animals" system, enabled, the identification of field exposed flocks and ultimately the eradication of H7N1, H7N3 and H5N2 infections. A bivalent H5/H7 prophylactic vaccination programme of defined poultry populations was introduced subsequently to increase their resistance to field infection. Retrospective analysis of the outbreaks identified important reservoir species such as quail, and demonstrated clearly the higher susceptibility of turkeys to infection. Data generated during 6 years of experience with vaccination against Avian Influenza (AI) indicate that it is a useful tool to limit secondary spread and possibly prevent the introduction of AI viruses in a susceptible population. The Italian AI control programme including vaccination was managed in a flexible manner and enabled the continuation of international trade. It is imperative that if vaccination is to be used to combat the current H5N1 epidemic it is used in conjunction with other measures and under official supervision. An extraordinary effort is required from international organisations to accredit control strategies so that harmonised and validated programs can be implemented. Transparency and sharing of field results from countries that are practising such programmes is crucial to the progressive control and ultimately the eradication of NAI infections in the animal reservoir.
journal_name
Vaccinejournal_title
Vaccineauthors
Capua I,Marangon Sdoi
10.1016/j.vaccine.2007.01.113subject
Has Abstractpub_date
2007-06-28 00:00:00pages
4987-95issue
27eissn
0264-410Xissn
1873-2518pii
S0264-410X(07)00172-7journal_volume
25pub_type
杂志文章,评审相关文献
VACCINE文献大全abstract::These studies were performed to determine the effects of GPI-0100, a semi synthetic Quillaja Saponin analog, formulated with herpes simplex virus type-1 (HSV-1) glycoprotein D (gD) on immunity to HSV. SKH-1 hairless mice, used as a model of herpes labialis, inoculated with HSV-1 results in facial lesions, virus replic...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2005.10.017
更新日期:2006-03-06 00:00:00
abstract::The immunogenicity of the live oral hybrid vaccine organism Salmonella typhi Ty21a/V. cholerae Inaba (EX210) following its growth in media containing variable concentrations of supplemental galactose was examined in human volunteer subjects. The local intestinal IgA-specific antibody responses to both typhoid and chol...
journal_title:Vaccine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0264-410x(91)90039-9
更新日期:1991-07-01 00:00:00
abstract::Praziquantel (PZQ), which is used to treat all forms of schistosomiasis, has been shown to induce strong T cell activities and decrease T regulatory cell levels. In our study, we investigated whether PZQ may be used as an adjuvant for a hepatitis B surface antigen (HBsAg) DNA vaccine (pcD-S2) in eliciting strong humor...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2009.10.101
更新日期:2010-02-23 00:00:00
abstract::Six adjuvant formulations were compared for their ability to potentiate the primary and memory antibody responses in mice to three companion animal vaccine immunogens--feline leukemia virus (FeLV), feline immunodeficiency virus (FIV), and a recombinantly-derived heartworm antigen. The combination of a novel bacterial ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(97)00136-9
更新日期:1997-12-01 00:00:00
abstract::Mutations arising in neutralizing epitopes of hepatitis C virus may play a role in the ability of the virus to escape control by neutralizing antibodies and in the establishment of chronic infections. An amino-acid substitution, Q412H, within a major conserved neutralization epitope EP I (aa 412-426) in the E2 glycopr...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2010.04.024
更新日期:2010-06-07 00:00:00
abstract::Genetic diversity and hypermutation contribute to difficulties in developing a vaccine against viruses like HIV and influenza. There are currently no known immune correlates of protection against HIV. This has made the development of a vaccine against HIV that would provide sterilizing immunity in the near future an i...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2007.12.008
更新日期:2008-06-06 00:00:00
abstract::Liquid vaccine dosage forms have limited stability and require refrigeration during their manufacture, distribution and storage. In contrast, solid vaccine dosage forms, produced by for example spray drying, offer improved storage stability and reduced dependence on cold-chain facilities. This is advantageous for mass...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2018.04.055
更新日期:2018-05-31 00:00:00
abstract::Patterns of microRNA expression appear to delineate the process of spontaneous neoplastic development-transformation (SPNDT) occurring in the African green monkey kidney (AGMK) VERO cell line (Teferedegne et al., 2010). Analysis of microarray data identified 6 microRNAs whose high-level of expression peaked when the W...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2017.04.004
更新日期:2017-10-04 00:00:00
abstract::Experimental whole-parasite immunization through concurrent administration of infectious Plasmodium sporozoites with drugs that prevent pathogenic blood-stage infection represents the current benchmark in malaria vaccine development. Key questions concerning translation remain, including the requirement for single-dos...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2014.07.112
更新日期:2014-10-14 00:00:00
abstract::Development of active targeted immunotherapeutics is a rapid developing field in the arena of chronic infectious diseases. The question of repeated, closely spaced administration of immunotherapeutics to achieve a rapid impact on the replicating agent is an important one. We analyzed here, using a prototype adenovirus...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2014.03.089
更新日期:2014-05-30 00:00:00
abstract::The hemagglutinin/protease (HA/P) seems to be an attractive locus for the insertion of heterologous tags in live cholera vaccine strains. A deltaCTXphi spontaneous mutant derived from a pathogenic strain of O139 Vibrio cholerae was sequentially manipulated to obtain hapA Colon, two colons celA derivatives which were l...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(02)00412-7
更新日期:2003-03-07 00:00:00
abstract::The measurement of measles-specific neutralizing antibodies, directed against the surface measles virus hemagglutinin and fusion proteins, is considered the gold standard in measles serology. We assessed functional measles-specific neutralizing antibody levels in a racially diverse cohort of 763 young healthy adolesce...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2011.04.037
更新日期:2011-06-15 00:00:00
abstract::Two modified live attenuated vaccines against the disease Rift Valley fever (RVF) have been tested for safety and efficacy in young calves. The RVF Smithburn vaccine produced in South Africa and used successfully to prevent and control the disease in endemic sub-Saharan countries was compared to the candidate vaccine ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2011.05.055
更新日期:2011-08-05 00:00:00
abstract::Thirty-two rhesus monkeys were used to evaluate the dose response of a recombinant HEV vaccine, and the efficacy of the vaccine based on the ORF2 protein of the Pakistani strain for pre- and post-exposure vaccination against intravenous challenge with homologous or heterologous virus was examined. Post-exposure vaccin...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(97)00145-x
更新日期:1997-12-01 00:00:00
abstract::The safety and immunogenicity of a new formulation of the inactivated hepatitis A vaccine, Avaxim, was evaluated in 189 children, aged 18 months to 15 years in a monocentric, open trial. Two vaccinations were given six months apart. Enrollment was balanced within three age groups: 18 months to 3 years, 4-8 years and 9...
journal_title:Vaccine
pub_type: 临床试验,杂志文章
doi:10.1016/s0264-410x(98)00461-7
更新日期:1999-04-09 00:00:00
abstract::A new strategy for designing synthetic vaccines is presented. In this approach synthetic peptides are conformationally restricted by replacing putative hydrogen bonds with covalent mimics. The chemistry for substituting a hydrazone-ethane link (N-N = CH-CH2-CH2) for an (i + 4)----i hydrogen bond in a pentapeptide with...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/s0264-410x(88)80007-0
更新日期:1988-04-01 00:00:00
abstract::Swine influenza virus (SIV) is not only an important respiratory pathogen in pigs but also a potent threat to human health. Although immunization with recombinant poxviruses expressing protective antigens as vaccines has been widely used for against many infectious diseases, development of recombinant swinepox virus (...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2012.02.028
更新日期:2012-04-26 00:00:00
abstract::Vaccine safety fears following media reports of adverse events led to low (50.3%) coverage in a supplementary measles-rubella immunization campaign in Georgia in 2008. Review of adverse events associated with the campaign identified 432 reports (<0.1% of ∼ 493,000 vaccinees) including 338 (78.2%) cases of syncope. The...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2010.07.043
更新日期:2010-09-07 00:00:00
abstract:INTRODUCTION:In France, the human papilloma (HPV) vaccine is recommended to all female adolescents, and since 2016 to men having sex with men (MSM) under the age of 27. Here, we aimed to explore HPV vaccine coverage in adult MSM living in France. METHODS:We elaborated an anonymous online questionnaire targeting MSM an...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2020.01.049
更新日期:2020-02-24 00:00:00
abstract::Since its registration in 2002, Gudair® vaccine has become the key tool for managing paratuberculosis in sheep in Australia. This study was conducted to evaluate its effectiveness in reducing paratuberculosis prevalence in 12 flocks over more than one decade. Flocks with variable initial prevalence (5, 4 and 3 with lo...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2016.08.064
更新日期:2016-09-30 00:00:00
abstract::Influenza viruses exhibit a fascinating level of antigenic heterogeneity that facilitates re-infection in the human population. The human antibody repertoire also manifests endless capability for variation in the genes that specify the portion of antibody molecules interacting with epitopes. A recent explosion of tech...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2009.10.124
更新日期:2009-12-30 00:00:00
abstract::The feasibility of a combined diphtheria-tetanus-acellular pertussis-hepatitis B (DTPa-HBV) vaccine was assessed and a comparison made of immunogenicity and reactogenicity to DTPa and HBV vaccines mixed in one syringe and to concomitant but separate injections as a primary vaccination course in three groups of infants...
journal_title:Vaccine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0264-410x(97)00089-3
更新日期:1997-10-01 00:00:00
abstract:INTRODUCTION:The World Health Organization (WHO) recommends vaccination of health workers against influenza, but uptake in low-resource settings remains low. To complement routine global data collection efforts we conducted a detailed survey on influenza vaccination policies for health workers in low-income and middle-...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2020.10.001
更新日期:2020-11-03 00:00:00
abstract::The screening of common genetic polymorphisms among candidate genes for AIDS pathology in HIV exposed cohort populations has led to the description of 20 AIDS restriction genes (ARGs), variants that affect susceptibility to HIV infection or to AIDS progression. The combination of high-throughput genotyping platforms a...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2007.12.054
更新日期:2008-06-06 00:00:00
abstract::The success of immunization programs in lowering the incidence of vaccine preventable diseases (VPDs) has led to increased public attention on potential health risks associated with vaccines. As a result, a scientifically rigorous response to investigating reported adverse events following immunization (AEFI) and effe...
journal_title:Vaccine
pub_type: 杂志文章,评审
doi:10.1016/j.vaccine.2019.07.041
更新日期:2020-11-17 00:00:00
abstract::Intranasal (i.n.) immunization of BALB/c mice with chimeric murine rotavirus EDIM (epizootic diarrhea of infant mice) VP6 and attenuated E. coli heat-labile toxin (LT), LT(R192G), stimulated >99% protection against rotavirus shedding after EDIM challenge. Here, we evaluated other potential adjuvants with chimeric VP6 ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/s0264-410x(02)00043-9
更新日期:2002-03-15 00:00:00
abstract:BACKGROUND:Micrurus venoms contain two main groups of toxic protein components: short-chain α-neurotoxins (SNtx) and phospholipases type A2 (PLA2). In North America, generally, the Micrurus venoms have low abundance of SNtx compared to that of PLA2s; however, both are highly toxic to mammals, and consequently both can ...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2020.12.052
更新日期:2021-02-05 00:00:00
abstract::Eight different vaccination schemes using four commercially available inactivated Bluetongue vaccines against serotypes 4 and 8 in three different combinations (setting 1-3) were tested under field conditions for their ability to generate a measurable immune response in sheep. Animals of setting 1 (groups A-D) were si...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2019.08.011
更新日期:2019-09-16 00:00:00
abstract::To assess human papillomavirus (HPV) prevalence and genotype distribution by age and cervical cytology/histology status among women undergoing routine gynecological examinations, and to discuss the possible impact on preventive strategies. Liquid-based cytology (LBC) samples were tested for HPV DNA, mRNA, and HPV geno...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2012.06.013
更新日期:2012-07-27 00:00:00
abstract::Immunization with amyloid-beta (Abeta) peptide reduces amyloid load in animal studies and in humans; however clinical trials resulted in the development of a pro-inflammatory cellular response to Abeta. Apoptosis has been employed to stimulate humoral and Th2-biased cellular immune responses. Thus, we sought to invest...
journal_title:Vaccine
pub_type: 杂志文章
doi:10.1016/j.vaccine.2008.12.044
更新日期:2009-02-25 00:00:00