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Enhancement of antibody response of turkeys to trivalent avian influenza vaccine by positively charged liposomal avridine adjuvant.

Abstract：

:Trivalent avian influenza (AIV) antigens (H4N8, H5N2 and H7N3), mixed with positively charged, negatively charged and neutral avridine-containing liposomes, and oil-emulsion were subcutaneously administered to 6-week-old turkeys. Charged liposomal avridine adjuvant, either positive or negative, produced a better antibody response than uncharged liposomal avridine or oil-emulsion adjuvants when used in a trivalent avian influenza vaccine. The antibody response to the different antigens was generally greater to the positively charged adjuvanted vaccine compared with the negatively or neutral charged or oil-emulsion adjuvanted vaccines and these differences were significant (P less than 0.05) with the three antigens. The results suggest that the positively charged liposomal avridine plays a significant role as adjuvant to the AIV antigens.

journal_name

Vaccine

journal_title

Vaccine

authors

Fatunmbi OO,Newman JA,Sivanandan V,Halvorson DA

doi

10.1016/0264-410x(92)90444-o

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

623-6

issue

9

eissn

0264-410X

issn

1873-2518

pii

0264-410X(92)90444-O

journal_volume

10

pub_type

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