当前位置： SCI文献检索 > VACCINE期刊下所有文献 > A clinical trial examining the effect of increased total CRM(197) carrier protein dose on the antibody response to Haemophilus influenzae type b CRM(197) conjugate vaccine.

A clinical trial examining the effect of increased total CRM(197) carrier protein dose on the antibody response to Haemophilus influenzae type b CRM(197) conjugate vaccine.

Abstract：

:CRM(197) is a carrier protein in certain conjugate vaccines. When multiple conjugate vaccines with the same carrier protein are administered simultaneously, reduced response to vaccines and/or antigens related to the carrier protein may occur. This study examined responses of infants who, in addition to diphtheria toxoid/tetanus toxoid/acellular pertussis vaccine (DTaP) received either diphtheria CRM(197)-based Haemophilus influenzae type b conjugate vaccine (HbOC) or HbOC and a diphtheria CRM(197)-based combination 9-valent pneumococcal conjugate vaccine/meningococcal group C conjugate vaccine. Administration of conjugate vaccines with CRM(197) carrier protein load >50 microg did not reduce response to CRM(197) conjugate vaccines or immunogenicity to immunologically cross-reactive diphtheria toxoid.

journal_name

Vaccine

journal_title

Vaccine

authors

Usonis V,Bakasenas V,Lockhart S,Baker S,Gruber W,Laudat F

doi

10.1016/j.vaccine.2008.05.087

subject

Has Abstract

pub_date

2008-08-18 00:00:00

pages

4602-7

issue

35

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(08)00682-8

journal_volume

26

pub_type

杂志文章,随机对照试验

相关文献

VACCINE文献大全
  • A field vaccine trial in Tanzania demonstrates partial protection against malignant catarrhal fever in cattle.

    abstract：:Malignant catarrhal fever (MCF) is a fatal lymphoproliferative disease of cattle that, in East Africa, results from transmission of the causative virus, alcelaphine herpesvirus 1 (AlHV-1), from wildebeest. A vaccine field trial involving an attenuated AlHV-1 virus vaccine was performed over two wildebeest calving seas...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2015.12.009

    authors： Lankester F,Russell GC,Lugelo A,Ndabigaye A,Mnyambwa N,Keyyu J,Kazwala R,Grant D,Percival A,Deane D,Haig DM,Cleaveland S

    更新日期：2016-02-03 00:00:00

  • Controlled human infections: A report from the controlled human infection models workshop, Leiden University Medical Centre 4-6 May 2016.

    abstract：:The principle of deliberately infecting humans with infectious agents in a controlled setting, so-called controlled human infections (CHI), is not novel. Many CHI models have a long history and were established decades ago such as the intentional exposure to yellow fever and dengue performed in the 1900's (Reed, 1902)...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.10.092

    authors： Roestenberg M,Mo A,Kremsner PG,Yazdanbakhsh M

    更新日期：2017-12-18 00:00:00

  • Global programme for control of hepatitis B infection.

    abstract：:The hepatitis B virus (HBV) has infected more than 2000 million persons alive today and 350 million persons are chronically infected carriers of the virus, at high risk of death from active hepatitis, cirrhosis and primary hepatocellular cancer. Each year approximately 1 million people die from the acute and chronic s...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(95)80050-n

    authors： Kane M

    更新日期：1995-01-01 00:00:00

  • Burden of hospitalizations attributable to rotavirus infection in children in Spain, period 1999-2000.

    abstract：:The aim of this study is to provide estimates on the incidence of rotavirus infection requiring hospitalization in children

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2003.11.037

    authors： Gil A,Carrasco P,Jiménez R,San-Martín M,Oyagüez I,González A

    更新日期：2004-06-02 00:00:00

  • Assessing the impact of wastage on pediatric vaccine immunization formulary costs using a vaccine selection algorithm.

    abstract：:Pediatric immunization is an important factor in providing protection against numerous common preventable diseases. The success of the pharmaceutical industry in developing new pediatric vaccines has resulted in a crowded recommended immunization schedule requiring several clinic visits over the first 12 years of life...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2003.11.018

    authors： Jacobson SH,Karnani T,Sewell EC

    更新日期：2004-06-02 00:00:00

  • Intranasal vaccination of infant mice induces protective immunity in the absence of nasal-associated lymphoid tissue.

    abstract：:Intranasal (i.n.) immunization is an effective regimen for the prophylaxis of respiratory diseases in early life. The aim of this study was to assess the need for nasal-associated lymphoid tissue (NALT) and cervical lymph nodes (CLN) in induction of protective immunity following mucosal vaccination of infant mice. We ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.01.027

    authors： Sabirov A,Metzger DW

    更新日期：2008-03-17 00:00:00

  • Invasive pneumococcal diseases in birth cohorts vaccinated with PCV-7 and/or PHiD-CV in the province of Quebec, Canada.

    abstract：BACKGROUND:The 10-valent protein D pneumococcal conjugate vaccine (PHiD-CV) was licensed on the basis of immunogenicity studies and there are no published data on its effectiveness to prevent invasive pneumococcal disease (IPD). In the province of Quebec, Canada, PHiD-CV was introduced in the summer of 2009, replacing ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.08.017

    authors： De Wals P,Lefebvre B,Defay F,Deceuninck G,Boulianne N

    更新日期：2012-10-05 00:00:00

  • Experimental immunisation and protection of guinea pigs with Vibrio cholerae toxoid and mucinases, neuraminidase and proteinase.

    abstract：:As measured by fluid accumulation in ileal loops, Vibrio cholerae mucinase complex, with or without toxoid, protected guinea pigs from challenges with V. cholerae live organisms and enterotoxin. The neuraminidase and proteinases of the complex were combined in modified oil emulsion or aluminum hydroxide adjuvants and ...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2003.12.004

    authors： Stewart-Tull DE,Lucas C,Bleakley CR

    更新日期：2004-06-02 00:00:00

  • Alterations in serotype-specific B cell responses to the 13-valent pneumococcal conjugate vaccine in aging HIV-infected adults.

    abstract：BACKGROUND:Advanced age and human immunodeficiency virus (HIV) infection are associated with increased pneumococcal disease risk. The impact of these factors on cellular responses to vaccination is unknown. METHODS:HIV-infected (HIV+) individuals 50-65 years old with CD4(+) Tcells/μl (CD4) >200 on antiretroviral thera...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2015.12.013

    authors： Ohtola JA,Khaskhely NM,Saul-Mcbeth JL,Iyer AS,Leggat DJ,Khuder SA,Westerink MAJ

    更新日期：2016-01-20 00:00:00

  • Influenza vaccination rates in Ontario children: implications for universal childhood vaccination policy.

    abstract：:The aims of this study were to estimate influenza vaccination coverage for children during the 2006-2007 influenza season in Ontario, Canada, where universal vaccination is available, and to compare the rate among children aged 6-23 months with corresponding rates from other Canadian provinces that specifically target...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2009.02.017

    authors： Moran K,Maaten S,Guttmann A,Northrup D,Kwong JC

    更新日期：2009-04-14 00:00:00

  • Immunogenicity of virus-like particles containing modified human immunodeficiency virus envelope proteins.

    abstract：:Extensive glycosylation and variable loops of the HIV envelope protein (Env) are reported to shield some neutralizing epitopes. Here, we investigated the immunogenicity of mutated HIV Envs presented in virus-like particles (VLPs). We immunized mice with simian human immunodeficiency virus (SHIV) VLPs containing mutant...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.01.107

    authors： Quan FS,Sailaja G,Skountzou I,Huang C,Vzorov A,Compans RW,Kang SM

    更新日期：2007-05-10 00:00:00

  • Anthrax vaccine: immunogenicity and safety of a dose-reduction, route-change comparison study in humans.

    abstract：:Anthrax vaccine adsorbed (AVA), an effective countermeasure against anthrax, is administered as six subcutaneous (SQ) doses over 18 months. To optimize the vaccination schedule and route of administration, we performed a prospective pilot study comparing the use of fewer AVA doses administered intramuscularly (IM) or ...

    journal_title：Vaccine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0264-410x(01)00462-5

    authors： Pittman PR,Kim-Ahn G,Pifat DY,Coonan K,Gibbs P,Little S,Pace-Templeton JG,Myers R,Parker GW,Friedlander AM

    更新日期：2002-01-31 00:00:00

  • Pandemic unadjuvanted influenza A (H1N1) vaccine in dermatomyositis and polymyositis: immunogenicity independent of therapy and no harmful effect in disease.

    abstract：:The goal of the present study was to evaluate the influence of the influenza A H1N1/2009 vaccine on dermatomyositis/polymyositis (DM/PM) disease parameters and the potential deleterious effect of therapy on immune response. Thirty-seven DM and 21 PM patients (Bohan and Peter's criteria) were gender- and age-matched to...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.10.063

    authors： Shinjo SK,de Moraes JC,Levy-Neto M,Aikawa NE,de Medeiros Ribeiro AC,Schahin Saad CG,Precioso A,Silva CA,Bonfá E

    更新日期：2012-12-17 00:00:00

  • Relation of activation-induced deaminase (AID) expression with antibody response to A(H1N1)pdm09 vaccination in HIV-1 infected patients.

    abstract：:The relevance of CD4+T-cells, viral load and age in the immunological response to influenza infection and vaccination in HIV-1 infected individuals has previously been pointed out. Our study aimed at assessing, in the setting of 2009 A(H1N1)pdm09 influenza vaccination, whether quantification of activation-induced deam...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2013.03.002

    authors： Cagigi A,Pensieroso S,Ruffin N,Sammicheli S,Thorstensson R,Pan-Hammarström Q,Hejdeman B,Nilsson A,Chiodi F

    更新日期：2013-04-26 00:00:00

  • An experimental vaccine cocktail for Plasmodium falciparum malaria.

    abstract：:Surface proteins from several different life-cycle stages of the malaria parasite Plasmodium falciparum were expressed at high levels in the yeast Saccharomyces cerevisiae. Purified proteins, both individually and in cocktails, were used to immunize mice and goats in conjunction with either Freund's adjuvant or a mura...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/0264-410x(93)90287-8

    authors： Bathurst IC,Gibson HL,Kansopon J,Hahm BK,Green KM,Chang SP,Hui GS,Siddiqui WA,Inselburg J,Millet P

    更新日期：1993-01-01 00:00:00

  • Precise answers to the wrong question: prospective clinical trials and the meta-analyses of pneumococcal vaccine in elderly and high-risk adults.

    abstract：:Ten prospective clinical trials conducted in elderly and high-risk adults have failed to show that pneumococcal vaccine prevents pneumococcal bacteraemia and all pneumonia. Several of these trials focused on unrepresentative populations and most had serious methodological problems. Few adequately considered sample siz...

    journal_title：Vaccine

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.vaccine.2003.09.027

    authors： Fedson DS,Liss C

    更新日期：2004-02-25 00:00:00

  • Measles serological survey in the Italian population: interpretation of results using mixture model.

    abstract：:In 2003-2004, a national measles seroprevalence study was conducted in Italy and data were analysed by using both commercial ELISA cut-off, and by applying a mixture model. Results of the two methods were compared and interpreted in the light of measles incidence, vaccination coverage and previous seroprevalence data....

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2008.05.094

    authors： Rota MC,Massari M,Gabutti G,Guido M,De Donno A,Ciofi degli Atti ML

    更新日期：2008-08-12 00:00:00

  • Prospects for oral replicating adenovirus-vectored vaccines.

    abstract：:Orally delivered replicating adenovirus (Ad) vaccines have been used for decades to prevent adenovirus serotype 4 and 7 respiratory illness in military recruits, demonstrating exemplary safety and high efficacy. That experience suggests that oral administration of live recombinant Ads (rAds) holds promise for immuniza...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2013.05.016

    authors： Deal C,Pekosz A,Ketner G

    更新日期：2013-07-11 00:00:00

  • Immunization of eyed channel catfish, Ictalurus punctatus, eggs with monovalent Flavobacterium columnare vaccine and bivalent F. columnare and Edwardsiella ictaluri vaccine.

    abstract：:The efficacy of a modified live monovalent Flavobacterium columnare vaccine and bivalent F. columnare and Edwardsiella ictaluri vaccines were evaluated following immersion vaccination of eyed channel catfish (Ictalurus punctatus) eggs. The modified live F. columnare vaccine was grown in modified Shieh broth and admini...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2006.09.055

    authors： Shoemaker CA,Klesius PH,Evans JJ

    更新日期：2007-01-22 00:00:00

  • Prenatal Tdap immunization and risk of maternal and newborn adverse events.

    abstract：:Many countries recommend combined tetanus toxoid, reduced diphtheria toxoid and acellular pertussis immunization (Tdap) during pregnancy to stimulate transplacental transmission of pertussis antibodies to newborns. The immune system can be altered during pregnancy, potentially resulting in differing immunization risks...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2017.06.071

    authors： Layton JB,Butler AM,Li D,Boggess KA,Weber DJ,McGrath LJ,Becker-Dreps S

    更新日期：2017-07-24 00:00:00

  • Enhancement of the protective efficacy of a Chlamydia trachomatis recombinant vaccine by combining systemic and mucosal routes for immunization.

    abstract：:Chlamydia trachomatis causes respiratory and sexually transmitted infections. Here, we tested a vaccine formulated with the recombinant major outer membrane protein from C. trachomatis mouse pneumonitis (CT-MoPn) for its ability to protect mice against an intranasal (i.n.) challenge. The adjuvants CpG and Montanide we...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2010.09.040

    authors： Ralli-Jain P,Tifrea D,Cheng C,Pal S,de la Maza LM

    更新日期：2010-11-10 00:00:00

  • Antitumour immunity mediated by mannan-modified adenovirus vectors expressing VE-cadherin.

    abstract：:Anti-angiogenesis represents an indispensible strategy for cancer therapy. As a strictly endothelial-specific adhesion molecule, vascular endothelial cadherin (VE-cadherin, VE-cad) is a promising anti-angiogenesis target. In this study a recombinant adenovirus vector modified with mannan was used to deliver VE-cad (Ad...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2011.03.109

    authors： Zhao Z,Yao Y,Ding Z,Chen X,Xie K,Luo Y,Zhang J,Chen X,Wu X,Xu J,Zhao J,Niu T,Liu J,Li Q,Zhang W,Wen Y,Su J,Hu B,Bu H,Wei Y,Wu Y

    更新日期：2011-06-06 00:00:00

  • Immunology of scorpion toxins and perspectives for generation of anti-venom vaccines.

    abstract：:Scorpions and other venomous animals contain concentrates of biologically active substances developed to block vital physiological and biochemical functions of the victims. These have contrasting human health concerns, provide important pharmacological raw material and pose a serious threat to human life and health in...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2004.12.027

    authors： Gazarian KG,Gazarian T,Hernández R,Possani LD

    更新日期：2005-05-16 00:00:00

  • The immune response to a two-dose schedule of quadrivalent HPV vaccine in 9-13 year-old girls: Is it influenced by age, menarche status or body mass index?

    abstract：:HPV vaccines are highly immunogenic. A two-dose schedule for 9-14 year-old is recommended. However, no data exist regarding the impact of age, menarche status and body mass index (BMI) on the immune response to a two-dose schedule. In this post-hoc analysis, we present antibody titers to HPV6/11/16/18 in 9-13 year-old...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2019.09.089

    authors： Sauvageau C,Gilca V,Donken R,Fan SY,Ogilvie G,Dobson S

    更新日期：2019-11-20 00:00:00

  • Pneumococcal conjugate serotype distribution and predominating role of serotype 3 in German adults with community-acquired pneumonia.

    abstract：INTRODUCTION:Implementation of the 7-valent pneumococcal conjugate vaccine (PCV7) in infant vaccination programs has substantially reduced the burden of PCV7 serotypes also in adult community-acquired pneumonia (CAP). Currently, it is unclear, if this extensive herd protection effect can be extrapolated to the addition...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2019.11.026

    authors： Forstner C,Kolditz M,Kesselmeier M,Ewig S,Rohde G,Barten-Neiner G,Rupp J,Witzenrath M,Welte T,Pletz MW,CAPNETZ study group.

    更新日期：2020-01-29 00:00:00

  • Protective effect of PCV vaccine against experimental pneumococcal challenge in adults is primarily mediated by controlling colonisation density.

    abstract：:Widespread use of Pneumococcal Conjugate Vaccines (PCV) has reduced vaccine-type nasopharyngeal colonisation and invasive pneumococcal disease. In a double-blind, randomised controlled trial using the Experimental Human Pneumococcal Challenge (EHPC) model, PCV-13 (Prevenar-13) conferred 78% protection against colonisa...

    journal_title：Vaccine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.vaccine.2019.05.080

    authors： German EL,Solórzano C,Sunny S,Dunne F,Gritzfeld JF,Mitsi E,Nikolaou E,Hyder-Wright AD,Collins AM,Gordon SB,Ferreira DM

    更新日期：2019-07-09 00:00:00

  • Generation of recombinant bacillus Calmette-Guérin and Mycobacterium smegmatis expressing BfpA and intimin as vaccine vectors against enteropathogenic Escherichia coli.

    abstract：:Enteropathogenic Escherichia coli (EPEC) is an important cause of diarrhea in children. EPEC adheres to the intestinal epithelium and causes attaching and effacing (A/E) lesions. Recombinant Mycobacterium smegmatis (Smeg) and Mycobacterium bovis BCG strains were constructed to express either BfpA or intimin. The entir...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2012.05.083

    authors： Vasconcellos HL,Scaramuzzi K,Nascimento IP,Da Costa Ferreira JM Jr,Abe CM,Piazza RM,Kipnis A,Dias da Silva W

    更新日期：2012-09-07 00:00:00

  • A global perspective of vaccination of healthcare personnel against measles: systematic review.

    abstract：:Measles transmission has been well documented in healthcare facilities. Healthcare personnel who are unvaccinated and who lack other evidence of measles immunity put themselves and their patients at risk for measles. We conducted a systematic literature review of measles vaccination policies and their implementation i...

    journal_title：Vaccine

    pub_type： 杂志文章,评审

    doi：10.1016/j.vaccine.2013.11.005

    authors： Fiebelkorn AP,Seward JF,Orenstein WA

    更新日期：2014-08-27 00:00:00

  • The effectiveness of seasonal trivalent inactivated influenza vaccine in preventing laboratory confirmed influenza hospitalisations in Auckland, New Zealand in 2012.

    abstract：BACKGROUND:Few studies report the effectiveness of trivalent inactivated influenza vaccine (TIV) in preventing hospitalisation for influenza-confirmed respiratory infections. Using a prospective surveillance platform, this study reports the first such estimate from a well-defined ethnically diverse population in New Ze...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2014.04.013

    authors： Turner N,Pierse N,Bissielo A,Huang QS,Baker MG,Widdowson MA,Kelly H,SHIVERS investigation team.

    更新日期：2014-06-17 00:00:00

  • Immunisation with a plasmid DNA vaccine encoding gonadotrophin releasing hormone (GnRH-I) and T-helper epitopes in saline suppresses rodent fertility.

    abstract：:Research into active immunisation against gonadotrophin releasing hormone (GnRH-I) has gained widespread acceptance as a means of controlling reproduction and behaviour of farm, companion and wild animals. Many studies describe the use of multiple copies of the self-peptide in linear alignment and conjugation with a l...

    journal_title：Vaccine

    pub_type： 杂志文章

    doi：10.1016/j.vaccine.2007.12.052

    authors： Khan MA,Ogita K,Ferro VA,Kumasawa K,Tsutsui T,Kimura T

    更新日期：2008-03-04 00:00:00