Once upon a time there was beta-catenin in cadherin-mediated signalling.

Abstract:

:beta-Catenin was initially characterized as a protein interacting with the cadherin cytoplasmic tail and regulating cell-cell contacts and actin cytoskeleton interactions. Moreover, the gene coding for the Drosophila orthologue of beta-catenin, armadillo, was independently identified downstream of wingless in the segment-polarity signalling pathway. In fact, beta-catenin/Armadillo turned out to be key mediators of the Wnt/Wingless pathways in vertebrates and invertebrates. beta-Catenin participates in both adhesion and signalling functions in a mutually exclusive manner; bound to cadherins at the plasma membrane or 'unbound' in cytosolic or nuclear complexes. This model had placed beta-catenin at the crossroads between cadherin and Wnt signalling, leading to the dogma of inhibition of beta-catenin signalling by cadherins.

journal_name

Biol Cell

journal_title

Biology of the cell

authors

Gavard J,Mège RM

doi

10.1042/BC20040531

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

921-6

issue

12

eissn

0248-4900

issn

1768-322X

pii

BC20040531

journal_volume

97

pub_type

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