The apicoplast of Plasmodium falciparum is translationally active.

abstract：:The interaction of Neisseria meningitidis with the meninges that surround and protect the brain is a pivotal event in the progression of bacterial meningitis. Two models of the human meninges were established in vitro, using (i) sections of fresh human brain and (ii) cultures of viable cells grown from human meningiom...

journal_title：Molecular microbiology

authors： Hardy SJ,Christodoulides M,Weller RO,Heckels JE

更新日期：2000-05-01 00:00:00

abstract：:Pneumococcus has been shown to bind to epithelial cells of the nasopharynx and lung, and to endothelial cells of the peripheral vasculature. To characterize bacterial elements required for attachment to these cell types, a library of genetically altered pneumococci with defects in exported proteins was screened for th...

journal_title：Molecular microbiology

authors： Spellerberg B,Cundell DR,Sandros J,Pearce BJ,Idanpaan-Heikkila I,Rosenow C,Masure HR

更新日期：1996-02-01 00:00:00

abstract：:The phsA gene encodes phenoxazinone synthase (PHS), which catalyses the penultimate step in the pathway for actinomycin biosynthesis in Streptomyces antibioticus. The phsA promoter strikingly resembles a putative Streptomyces sigma E cognate promoter, and purified E sigma E holoenzyme transcribed the phsA promoter in ...

journal_title：Molecular microbiology

authors： Jones GH,Paget MS,Chamberlin L,Buttner MJ

更新日期：1997-01-01 00:00:00

abstract：:Monoclonal antibodies against the lipopolysaccharide (LPS) of the deep rough mutant I-69 Rd-/b+ of Haemophilus influenzae were obtained after immunization of mice with sheep erythrocytes which had been coated with de-O-acylated LPS. Characterization of antibodies was performed by enzyme immuno assay (EIA) using LPS or...

journal_title：Molecular microbiology

authors： Rozalski A,Brade L,Kosma P,Moxon R,Kusumoto S,Brade H

更新日期：1997-02-01 00:00:00

abstract：:Peptidoglycan (PG), the major component of the bacterial cell wall, is one large macromolecule. To allow for the different curvatures of PG at cell poles and division sites, there must be local differences in PG architecture and eventually also chemistry. Here we report such local differences in the Gram-positive rod-...

journal_title：Molecular microbiology

authors： Morales Angeles D,Liu Y,Hartman AM,Borisova M,de Sousa Borges A,de Kok N,Beilharz K,Veening JW,Mayer C,Hirsch AK,Scheffers DJ

更新日期：2017-04-01 00:00:00

abstract：:The flagellar genes of Caulobacter crescentus are expressed under cell-cycle control. Expression is regulated by both flagellar assembly cues and cell-cycle events. In this paper we define the sequences required for the expression of the flgF operon, a new class of sigma 54 flagellar promoter. This promoter type is ex...

journal_title：Molecular microbiology

authors： Marques MV,Gober JW

更新日期：1995-04-01 00:00:00

abstract：:Lyme disease is a tick-transmitted infection caused by the spirochete Borrelia burgdorferi. Ticks deposit B. burgdorferi into the dermis of the host, where they eventually become associated with collagen fibres. We demonstrated previously that B. burgdorferi is unable to bind collagen, but can bind the collagen-associ...

journal_title：Molecular microbiology

authors： Guo BP,Brown EL,Dorward DW,Rosenberg LC,Höök M

更新日期：1998-11-01 00:00:00

abstract：:An internal segment of the (p)ppGpp synthetase gene, relA, of Streptomyces coelicolor A3(2) was amplified from genomic DNA using the polymerase chain reaction and used as a hybridization probe to isolate the complete gene from a cosmid library. relA lies downstream of a gene (apt) that apparently encodes adenine phosp...

journal_title：Molecular microbiology

authors： Chakraburtty R,White J,Takano E,Bibb M

更新日期：1996-01-01 00:00:00

abstract：:Defensins represent an evolutionarily conserved group of small peptides with potent antibacterial activities. We report here that extracellular proteinases secreted by the human pathogens Pseudomonas aeruginosa, Enterococcus faecalis and Streptococcus pyogenes release dermatan sulphate by degrading dermatan sulphate-c...

journal_title：Molecular microbiology

authors： Schmidtchen A,Frick IM,Björck L

更新日期：2001-02-01 00:00:00

abstract：:Myxococcus xanthus is a Gram-negative, soil-dwelling bacterium with a complex life cycle which includes fruiting body formation and sporulation in response to starvation. This developmental process is slow, requiring a minimum of 24-48 h, and requires cells to be at high cell density on a solid surface. It is known th...

journal_title：Molecular microbiology

authors： O'Connor KA,Zusman DR

更新日期：1997-05-01 00:00:00

abstract：:Expression of type 1 fimbriae in Salmonella enterica serovar Typhimurium undergoes phase variation or alteration between a fimbriate and a non-fimbriate phenotype. This variation is known to be dependent upon environmental conditions in vitro and is thought to be a complex process involving regulation by a number of p...

journal_title：Molecular microbiology

authors： Tinker JK,Clegg S

更新日期：2001-05-01 00:00:00

abstract：:GPI-anchoring is a universal and critical post-translational protein modification in eukaryotes. In fungi, many cell wall proteins are GPI-anchored, and disruption of GPI-anchored proteins impairs cell wall integrity. After being synthesized and attached to target proteins, GPI anchors undergo modification on lipid mo...

journal_title：Molecular microbiology

authors： Chung D,Thammahong A,Shepardson KM,Blosser SJ,Cramer RA

更新日期：2014-06-01 00:00:00

abstract：:The pulmonary pathogen Legionella pneumophila uses the Dot/Icm type IV secretion system (T4SS) to replicate inside host cells. This apparatus translocates proteins into macrophages to alter their endocytic pathway and enable bacterial growth. Although the secretion ATPase DotB is critical for T4SS function, its specif...

journal_title：Molecular microbiology

authors： Sexton JA,Yeo HJ,Vogel JP

更新日期：2005-07-01 00:00:00

abstract：:We report here the construction and analysis of insertional mutations in each of the three genes of the gltBDF operon and the nucleotide sequence of the region downstream from gltD. Two open reading frames were identified, the first of which corresponds to gltF. The gltB and gltD genes code for the large and small sub...

journal_title：Molecular microbiology

authors： Castaño I,Flores N,Valle F,Covarrubias AA,Bolivar F

更新日期：1992-09-01 00:00:00

abstract：:Ethylenediaminetetraacetate (EDTA) is currently the most abundant organic pollutant due to its recalcitrance and extensive use. Only a few bacteria can degrade it, using EDTA monooxygenase (EmoA) to initiate the degradation. EmoA is an FMNH2 -dependent monooxygenase that requires an NADH:FMN oxidoreductase (EmoB) to p...

journal_title：Molecular microbiology

authors： Jun SY,Lewis KM,Youn B,Xun L,Kang C

更新日期：2016-06-01 00:00:00

abstract：:In cell-free Yersinia pseudotuberculosis culture supernatants, we have chemically characterized three N-acyl homoserine lactone (AHL) molecules, N-octanoyl homoserine lactone (C8-HSL), N-(3-oxohexanoyl)homoserine lactone (3-oxo-C6-HSL) and N-hexanoyl homoserine lactone (C6-HSL). We have identified, cloned and sequence...

journal_title：Molecular microbiology

authors： Atkinson S,Throup JP,Stewart GS,Williams P

更新日期：1999-09-01 00:00:00

abstract：:Roughly 10% of all genes in Escherichia coli are controlled by the global transcription factor Lrp, which responds to nutrient availability. Bioinformatically, we identified lrp as one of several putative targets for the sRNA MicF, which is transcriptionally downregulated by Lrp. Deleting micF results in higher Lrp le...

journal_title：Molecular microbiology

authors： Holmqvist E,Unoson C,Reimegård J,Wagner EG

更新日期：2012-05-01 00:00:00

abstract：:Bacteria co-ordinate their social behaviour in a density-dependent manner by production of diffusible signal molecules by a process known as quorum sensing (QS). It is generally assumed that in homogenous environments and at high cell density, QS synchronizes cells in the population to perform collective social tasks ...

journal_title：Molecular microbiology

authors： Pradhan BB,Chatterjee S

更新日期：2014-05-01 00:00:00

abstract：:A new mechanism for the turning-off of gene expression in Salmonella Pathogenicity Island 1 (SPI-1) is proposed by Espinosa and Casadesús, which involves the action of the LeuO quiescent regulator, by two different pathways. A major one through the activation of the hilE gene, where the HilE protein would in turn inac...

journal_title：Molecular microbiology

authors： Bustamante VH,Calva E

更新日期：2014-03-01 00:00:00

abstract：:Gram-negative bacteria have evolved numerous pathways to secrete proteins across their complex cell envelopes. Here, we describe a protein secretion system that uses a holin membrane protein in tandem with a cell wall-editing enzyme to mediate the secretion of substrate proteins from the periplasm to the cell exterior...

journal_title：Molecular microbiology

authors： Palmer T,Finney AJ,Saha CK,Atkinson GC,Sargent F

更新日期：2020-09-04 00:00:00

abstract：:The prnA gene codes for a transcriptional activator that mediates proline induction of four other genes involved in proline utilization as a nitrogen and/or carbon source in Aspergillus nidulans. In this paper, we present the genomic and cDNA sequence and the transcript map of prnA. The PrnA protein belongs to the Zn ...

journal_title：Molecular microbiology

authors： Cazelle B,Pokorska A,Hull E,Green PM,Stanway G,Scazzocchio C

更新日期：1998-04-01 00:00:00

abstract：:The DnaA protein of Escherichia coli is a multi-functional protein which, In addition to promoting initiation of replication, can regulate the initiation or termination of transcription of a variety of genes. It acts by binding to DNA at a defined sequence, termed a DnaA-box. Three candidate DnaA-boxes which occur wit...

journal_title：Molecular microbiology

authors： Smith RW,McAteer S,Masters M

更新日期：1996-07-01 00:00:00

abstract：:The creA gene of A. nidulans encodes a wide-domain regulatory protein mediating carbon catabolite repression. Northern blot analysis of creA mRNA revealed a complex expression profile: the addition of monosaccharides to a carbon-starved culture of A. nidulans provoked a strong transient stimulation of creA transcript ...

journal_title：Molecular microbiology

authors： Strauss J,Horvath HK,Abdallah BM,Kindermann J,Mach RL,Kubicek CP

更新日期：1999-04-01 00:00:00

abstract：:NsrR is a nitric oxide (NO)-sensitive transcription repressor that controls NO metabolism in a wide range of bacteria. In Bacillus subtilis, NsrR represses transcription of the nitrite reductase (nasDEF) genes that are under positive control of the ResD-ResE two-component signal transduction system. Derepression is ac...

journal_title：Molecular microbiology

authors： Kommineni S,Yukl E,Hayashi T,Delepine J,Geng H,Moënne-Loccoz P,Nakano MM

更新日期：2010-12-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are persistent and toxic environmental pollutants that accumulate in anoxic habitats. With the exception of naphthalene, nothing is known about the microbial degradation of PAH in these environments. The challenge that must be met in anaerobic PAH degradation is the destabilizat...

journal_title：Molecular microbiology

authors： Sawers RG

更新日期：2015-01-01 00:00:00

abstract：:Photorhabdus and Xenorhabdus bacteria colonize the intestines of the infective soil-dwelling stage of entomophagous nematodes, Heterorhabditis and Steinernema, respectively. These nematodes infect susceptible insect larvae and release the bacteria into the insect blood. The bacteria kill the insect larvae and convert ...

journal_title：Molecular microbiology

authors： Goodrich-Blair H,Clarke DJ

更新日期：2007-04-01 00:00:00

abstract：:We have demonstrated hypervariability of native short-motif repeats (microsatellites) in Escherichia coli. Twenty-five of the longest microsatellites in the E. coli genome were identified. These were analysed for length variability among 22 wild-type (non-mutator) isolates from the E. coli collection of reference (ECO...

journal_title：Molecular microbiology

authors： Metzgar D,Thomas E,Davis C,Field D,Wills C

更新日期：2001-01-01 00:00:00

abstract：:Understanding the mechanisms of polysialic acid synthesis in Escherichia coli K1 requires a molecular description of the polymerase complex. Since the number of potential models explaining polysialic acid assembly would be constrained if only one sialyltransferase were required for this process, the phenotypes of a si...

journal_title：Molecular microbiology

authors： Steenbergen SM,Vimr ER

更新日期：1990-04-01 00:00:00

abstract：:In spite of displaying the most extreme dormancy and resistance properties known among living systems, bacterial endospores retain an alert environment-sensing mechanism that can respond within seconds to the presence of specific germinants. This germination response is triggered in the absence of both germinant and g...

journal_title：Molecular microbiology

authors： Foster SJ,Johnstone K

更新日期：1990-01-01 00:00:00

abstract：:An msDNA operon, consisting of genes for msDNA and a reverse transcriptase, is present in Escherichia coliB and absent from E. coliK12. We have found that the msDNA operon is located on a DNA fragment, longer than 15kb, that is absent from E. coliK12. Using conjugation, P1 transduction, and nucleic acid hybridization ...

journal_title：Molecular microbiology

authors： Lim D,Maas WK

更新日期：1990-12-01 00:00:00