The function of CreA, the carbon catabolite repressor of Aspergillus nidulans, is regulated at the transcriptional and post-transcriptional level.

abstract：:In the yeast Saccharomyces cerevisiae, genes involved in phospholipid biosynthesis are activated by ICRE (inositol/choline-responsive element) up-stream motifs and the corresponding heterodimeric binding factor, Ino2 + Ino4. Both Ino2 and Ino4 contain basic helix-loop-helix (bHLH) domains required for ICRE binding, wh...

journal_title：Molecular microbiology

authors： Dietz M,Heyken WT,Hoppen J,Geburtig S,Schüller HJ

更新日期：2003-05-01 00:00:00

abstract：:Rpc25 is a strongly conserved subunit of RNA polymerase III with homology to Rpa43 in RNA polymerase I, Rpb7 in RNA polymerase II and the archaeal RpoE subunit. A central domain of Rpc25 can replaced the corresponding region of Rpb7 with little or no growth defect, underscoring the functional relatedness of these prot...

journal_title：Molecular microbiology

authors： Zaros C,Thuriaux P

更新日期：2005-01-01 00:00:00

abstract：:Chemoreceptors play a central role in chemotaxis, allowing bacteria to detect chemical gradients and bias their swimming behavior in order to navigate toward favorable environments. The genome of the kiwifruit pathogen, Pseudomonas syringae pv. actinidiae (Psa) strain NZ-V13 encodes 43 predicted chemoreceptors, none o...

journal_title：Molecular microbiology

authors： McKellar JL,Minnell JJ,Gerth ML

更新日期：2015-05-01 00:00:00

abstract：:Transcript degradation is a key step in gene regulation. In eukaryotes, mRNA decay is generally initiated by removal of the poly(A) tail mediated by the Ccr4-Caf1-Not complex. Deadenylated transcripts are then rapidly degraded, primarily via the decapping-dependent pathway. Components of this pathway can be localized ...

journal_title：Molecular microbiology

authors： Morozov IY,Jones MG,Spiller DG,Rigden DJ,Dattenböck C,Novotny R,Strauss J,Caddick MX

更新日期：2010-04-01 00:00:00

abstract：:We used DNA macroarray analysis to identify genes that respond to the status of the intracellular acetyl phosphate (acP) pool. Genes whose expression correlated negatively with the ability to synthesize acP (i.e. negatively regulated genes) function primarily in flagella biosynthesis, a result consistent with observat...

journal_title：Molecular microbiology

authors： Wolfe AJ,Chang DE,Walker JD,Seitz-Partridge JE,Vidaurri MD,Lange CF,Prüss BM,Henk MC,Larkin JC,Conway T

更新日期：2003-05-01 00:00:00

abstract：:The AppA protein of Rhodobacter sphaeroides is unique in its ability to sense and transmit redox signals as well as light signals. By functioning as antagonist to the PpsR transcriptional repressor, it regulates the expression of photosynthesis genes in response to these environmental stimuli. Here we show binding of ...

journal_title：Molecular microbiology

authors： Han Y,Meyer MH,Keusgen M,Klug G

更新日期：2007-05-01 00:00:00

abstract：:Prediction studies, conformational analyses and membrane-topology mapping lead to the conclusion that the penicillin sensory transducer, BlaR, involved in the inducibility of beta-lactamase synthesis in Bacillus licheniformis, is embedded in the plasma membrane bilayer via four transmembrane segments TM1-TM4 that form...

journal_title：Molecular microbiology

authors： Hardt K,Joris B,Lepage S,Brasseur R,Lampen JO,Frère JM,Fink AL,Ghuysen JM

更新日期：1997-03-01 00:00:00

abstract：:The overall transcription of DNA has previously been demonstrated to proceed at extremely high levels of accuracy. We review the evidence that the process of transcription is subject to proof-reading in the Hopfield sense. In addition, we speculate that the proof-reading activity associated with transcription is subje...

journal_title：Molecular microbiology

authors： Libby RT,Gallant JA

更新日期：1991-05-01 00:00:00

abstract：:Natural competence in Streptococcus pneumoniae is regulated by a quorum-sensing mechanism consisting of a competence-stimulating peptide (CSP), its dedicated secretion apparatus (ComAB), its histidine kinase receptor (ComD) and a response regulator (ComE). In this report, we show that ComE is a DNA-binding protein tha...

journal_title：Molecular microbiology

authors： Ween O,Gaustad P,Håvarstein LS

更新日期：1999-08-01 00:00:00

abstract：:Gene expression in fungi by ambient pH is regulated via a conserved signalling cascade whose terminal component is the zinc finger transcription factor PacC/Rim1p. We have identified a pacC orthologue in the vascular wilt pathogen Fusarium oxysporum that binds the consensus 5'-GCCAAG-3' sequence and is proteolytically...

journal_title：Molecular microbiology

authors： Caracuel Z,Roncero MI,Espeso EA,González-Verdejo CI,García-Maceira FI,Di Pietro A

更新日期：2003-05-01 00:00:00

abstract：:Biofilm formation of Staphylococcus epidermidis on smooth polymer surfaces has been shown to be mediated by the ica operon. Upon activation of this operon, a polysaccharide intercellular adhesin (PIA) is synthesized that supports bacterial cell-to-cell contacts and triggers the production of thick, multilayered biofil...

journal_title：Molecular microbiology

authors： Ziebuhr W,Krimmer V,Rachid S,Lössner I,Götz F,Hacker J

更新日期：1999-04-01 00:00:00

abstract：:Misfolded proteins are usually arrested in the endoplasmic reticulum (ER) and degraded by the ER-associated degradation (ERAD) machinery. Several mutant alleles of PMA1, the gene coding for the plasma membrane H(+)-ATPase, render misfolded proteins that are retained in the ER and degraded by ERAD. A subset of misfolde...

journal_title：Molecular microbiology

authors： Mazón MJ,Eraso P,Portillo F

更新日期：2007-02-01 00:00:00

abstract：:Accurate aminoacyl-tRNA synthesis is essential for correct translation of the genetic code in all organisms. Whereas many aspects of this process are conserved, others display a surprisingly high level of divergence from the canonical Escherichia coli model system. These differences are most pronounced in archaea wher...

journal_title：Molecular microbiology

authors： Praetorius-Ibba M,Ibba M

更新日期：2003-05-01 00:00:00

abstract：:Post-translational modifications account for much of the biological diversity generated at the proteome level. Of these, glycosylation is the most prevalent. Long thought to be unique to Eukarya, it is now clear that both Bacteria and Archaea are also capable of N-glycosylation, namely the covalent linkage of oligosac...

journal_title：Molecular microbiology

authors： Yurist-Doutsch S,Chaban B,VanDyke DJ,Jarrell KF,Eichler J

更新日期：2008-06-01 00:00:00

abstract：:The Bacillus subtilis GlnR transcription factor regulates gene expression in response to changes in nitrogen availability. Glutamine synthetase transmits the nitrogen regulatory signal to GlnR. The DNA-binding activity of GlnR is activated by a transient protein-protein interaction with feedback-inhibited glutamine sy...

journal_title：Molecular microbiology

authors： Wray LV Jr,Fisher SH

更新日期：2008-04-01 00:00:00

abstract：:Type IV secretion systems are increasingly recognized as important virulence determinants of Gram-negative bacterial pathogens. While the examination of several type IV-secreted proteins suggested that their secretion depends on C-terminal signals, the nature of these signals and their conservation among different sys...

journal_title：Molecular microbiology

authors： Hohlfeld S,Pattis I,Püls J,Plano GV,Haas R,Fischer W

更新日期：2006-03-01 00:00:00

abstract：:In their natural habitats, microorganisms are often exposed to osmolality changes in the environment. The osmotic stress must be sensed and converted into an activity change of specific enzymes and transport proteins and/or it must trigger their synthesis such that the osmotic imbalance can be rapidly restored. On the...

journal_title：Molecular microbiology

authors： Poolman B,Glaasker E

更新日期：1998-07-01 00:00:00

abstract：:Trans-acting small regulatory RNAs (sRNAs) are key players in the regulation of gene expression in bacteria. There are hundreds of different sRNAs in a typical bacterium, which in contrast to eukaryotic microRNAs are more heterogeneous in length, sequence composition, and secondary structure. The vast majority of sRNA...

journal_title：Molecular microbiology

authors： Georg J,Lalaouna D,Hou S,Lott SC,Caldelari I,Marzi S,Hess WR,Romby P

更新日期：2020-03-01 00:00:00

abstract：:Post-translational proteolysis-dependent regulation of critical cellular processes is a common feature in bacteria. The Escherichia coli Lon protease is involved in the control of the SOS response, acid tolerance and nutritional deprivation. Moreover, Lon plays a role in the regulation of toxin-antitoxin (TA) systems ...

journal_title：Molecular microbiology

authors： Langklotz S,Narberhaus F

更新日期：2011-06-01 00:00:00

abstract：:A new virus of halophilic Archaea is reported by Liu et al., and is remarkable in many ways. SNJ2 is the first temperate, pleomorphic virus (pleolipovirus) that integrates into the genome of its host. Analyses of the virus structure and its genome have provided an unexpected puzzle while at the same time solving anoth...

journal_title：Molecular microbiology

authors： Dyall-Smith M,Porter K

更新日期：2015-12-01 00:00:00

abstract：:A number of small, multicopy plasmids from Gram-positive bacteria replicate by an asymmetric rolling-circle mechanism. Previous studies with several of these plasmids have identified a palindromic sequence, SSOA, that acts as the single-strand origin (SSO) for the replication of the lagging-strand DNA. Although not al...

journal_title：Molecular microbiology

authors： Dempsey LA,Zhao AC,Khan SA

更新日期：1995-02-01 00:00:00

abstract：:We previously characterized a defective-folding mutant of maltose-binding protein of Escherichia coli, MalE31, which formed periplasmic inclusion bodies. Here, we show that MalE31 aggregation does not affect bacterial growth at 30 degrees C but is lethal at 37 degrees C. Surprisingly, under mild heat shock conditions ...

journal_title：Molecular microbiology

authors： Hunke S,Betton JM

更新日期：2003-12-01 00:00:00

abstract：:A virulence-associated region in the genome of Dichelobacter nodosus has been shown to contain an integrase gene which is highly related to the integrases of Shigella flexneri phage Sf6 and coliphages P4 and phi R73, together with open reading frames (vapB, C and D) related to genes borne on plasmids in Neisseria gono...

journal_title：Molecular microbiology

authors： Cheetham BF,Katz ME

更新日期：1995-10-01 00:00:00

abstract：:Protein kinase C constitutes a family of serine-threonine kinases found in all eukaryotes and implicated in a wide range of cellular functions, including regulation of cell growth, cellular differentiation and immunity. Here, we present three independent lines of evidence which indicate that protein kinase C is essent...

journal_title：Molecular microbiology

authors： Penn TJ,Wood ME,Soanes DM,Csukai M,Corran AJ,Talbot NJ

更新日期：2015-10-01 00:00:00

abstract：:Accumulation of stalled ribosomes at the 3' end of mRNA without a stop codon (non-stop mRNA) is supposed to be toxic to bacterial cells. Escherichia coli has at least two distinct systems to rescue such stalled ribosomes: SsrA-dependent trans-translation and ArfA-dependent ribosome rescue. Combination of the ssrA and ...

journal_title：Molecular microbiology

authors： Chadani Y,Ono K,Kutsukake K,Abo T

更新日期：2011-05-01 00:00:00

abstract：:We present evidence showing that rpoS (katF) is a regulator of katG gene transcription in an oxyR-independent manner. Mutation of the rpoS gene in several different Escherichia coli strains caused a significant reduction in catalase HPI activity. In rpoS-delta oxyR double mutants, the level of HPI was considerably low...

journal_title：Molecular microbiology

authors： Ivanova A,Miller C,Glinsky G,Eisenstark A

更新日期：1994-05-01 00:00:00

abstract：:The pulmonary pathogen Legionella pneumophila uses the Dot/Icm type IV secretion system (T4SS) to replicate inside host cells. This apparatus translocates proteins into macrophages to alter their endocytic pathway and enable bacterial growth. Although the secretion ATPase DotB is critical for T4SS function, its specif...

journal_title：Molecular microbiology

authors： Sexton JA,Yeo HJ,Vogel JP

更新日期：2005-07-01 00:00:00

abstract：:We have devised a simple method for the reconstitution of bacterial membrane proteins directly from small (1-20 ml) volumes of cell culture, thus eliminating the preparation of membrane vesicles. Cells are subjected to simultaneous lysozyme digestion and osmotic lysis, and after brief centrifugation ghosts are solubil...

journal_title：Molecular microbiology

authors： Varadhachary A,Maloney PC

更新日期：1990-08-01 00:00:00

abstract：:SigD and SigE (Salmonella invasion gene) are proteins needed for optimal invasion of Salmonella typhimurium into eukaryotic cells in vitro. SigD is a secreted protein and SigE is a putative chaperone required for SigD stability and/or secretion. SigD is secreted by a type III secretion apparatus encoded within a patho...

journal_title：Molecular microbiology

authors： Darwin KH,Miller VL

更新日期：2000-02-01 00:00:00

abstract：:A series of plasmids carrying an IRL-kan-IRR transposable cassette, in which IRL and IRR are the left- and right-terminal sequences of IS91, have been constructed. These cassettes could be complemented for transposition with similar efficiency when IS91 transposase was provided either in cis or in trans. A total of 87...

journal_title：Molecular microbiology

authors： Bernales I,Mendiola MV,de la Cruz F

更新日期：1999-07-01 00:00:00