Abstract:
:Natural competence in Streptococcus pneumoniae is regulated by a quorum-sensing mechanism consisting of a competence-stimulating peptide (CSP), its dedicated secretion apparatus (ComAB), its histidine kinase receptor (ComD) and a response regulator (ComE). In this report, we show that ComE is a DNA-binding protein that acts autocatalytically by binding to a region in its own promoter. Two additional ComE binding sites were identified in the pneumococcal genome, one in the promoter region of comAB and the other upstream of an ABC transporter of unknown function. A comparison of the ComE-binding sequences with the sequence motif previously found to be involved in the co-ordinated expression of the late genes revealed that they are unrelated. These findings indicate that ComE activates transcription of the late genes indirectly, i.e. via one or more intermediate factors.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Ween O,Gaustad P,Håvarstein LSdoi
10.1046/j.1365-2958.1999.01528.xsubject
Has Abstractpub_date
1999-08-01 00:00:00pages
817-27issue
4eissn
0950-382Xissn
1365-2958pii
mmi1528journal_volume
33pub_type
杂志文章abstract::Anammox bacteria exhibit remarkable and characteristic metabolic features that enable them to oxidize ammonium under anoxic conditions. Their ultrastructure is complex, with three compartments, comprising paryphoplasm, the riboplasm and the anammoxosome. The latter is surrounded by ladderane lipids, creating a lipid-s...
journal_title:Molecular microbiology
pub_type: 评论,杂志文章
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abstract::Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, plays a critical role in the orchestration of immune responses. S1P levels within the mammalian host are tightly regulated, in part through the activity of S1P lyase (S1PL) which catalyses its irreversible degradation. Herein, we describe the identifi...
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pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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journal_title:Molecular microbiology
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pub_type: 杂志文章
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更新日期:1997-03-01 00:00:00
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