The penicillin sensory transducer, BlaR, involved in the inducibility of beta-lactamase synthesis in Bacillus licheniformis is embedded in the plasma membrane via a four-alpha-helix bundle.

abstract：:The process of septation requires precise temporal and spatial organization of penicillin binding proteins (PBPs) and associated proteins for the deposition of new cell wall material. In most bacteria, the filamentous protein FtsZ organises PBPs into assemblies at the midcell which then constrict inwards as peptidogly...

journal_title：Molecular microbiology

authors： Cadby IT,Lovering AL

更新日期：2014-10-01 00:00:00

abstract：:SsrA is a tmRNA involved in tagging polypeptides on stalled ribosomes. The resulting fusion proteins are then degraded. We purified endogenous SsrA-tagged proteins by means of a genetically engineered SsrA and identified some of them. Analysis of the proteins suggested that they are tagged at their C-terminal extremit...

journal_title：Molecular microbiology

authors： Collier J,Binet E,Bouloc P

更新日期：2002-08-01 00:00:00

abstract：SUMMARY:The conserved bacterial protein RloC, a distant homologue of the tRNA(Lys) anticodon nuclease (ACNase) PrrC, is shown here to act as a wobble nucleotide-excising and Zn(++)-responsive tRNase. The more familiar PrrC is silenced by a genetically linked type I DNA restriction-modification (R-M) enzyme, activated b...

journal_title：Molecular microbiology

authors： Davidov E,Kaufmann G

更新日期：2008-09-01 00:00:00

abstract：:The involvement of signal transduction in the repair of radiation-induced damage to DNA has been known in eukaryotes but remains understudied in bacteria. This article for the first time demonstrates a role for the periplasmic lipoprotein (YfgL) with protein kinase activity transducing a signal for DNA strand break re...

journal_title：Molecular microbiology

authors： Khairnar NP,Kamble VA,Mangoli SH,Apte SK,Misra HS

更新日期：2007-07-01 00:00:00

abstract：:A transposon mutant of Escherichia coli 5K was isolated which reduced 10- to 50-fold the secreted extracellular haemolytic activity of cells carrying the complete hlyCABD operon while leaving unaffected the intracellular haemolytic activity and the levels of intracellular and extracellular haemolysin protein, HlyA. Th...

journal_title：Molecular microbiology

authors： Stanley PL,Diaz P,Bailey MJ,Gygi D,Juarez A,Hughes C

更新日期：1993-11-01 00:00:00

abstract：:Molecular analyses were applied to the genes encoding variants of the serosubtyping antigen, the class 1 outer membrane protein (PorA), from 55 serogroup A Neisseria meningitidis strains. These genes were evolutionarily stable and exhibited a limited range of genetic variation, primarily generated by recombination. Tr...

journal_title：Molecular microbiology

authors： Suker J,Feavers IM,Achtman M,Morelli G,Wang JF,Maiden MC

更新日期：1994-04-01 00:00:00

abstract：:A search was performed for a periplasmic molecular chaperone which may assist outer membrane proteins of Escherichia coli on their way from the cytoplasmic to the outer membrane. Proteins of the periplasmic space were fractionated on an affinity column with sepharose-bound outer membrane porin OmpF. A 17 kDa polypepti...

journal_title：Molecular microbiology

authors： Chen R,Henning U

更新日期：1996-03-01 00:00:00

abstract：:The virulence genes of the plant pathogen Agrobacterium tumefaciens are induced by more than 40 low-molecular-weight phenolic compounds. The prevailing opinion is that (i) wound-derived phenols produced on breach of the integrity of the cell wall act as the initiating signal in a series of events which results in host...

journal_title：Molecular microbiology

authors： Duban ME,Lee K,Lynn DG

更新日期：1993-03-01 00:00:00

abstract：:The bacterial actin homologue MreB forms a helix underneath the cytoplasmic membrane and was shown to be essential in the morphogenesis of the rod-shaped cells. Additionally, MreB was implicated to be involved in DNA segregation. However, in our hands the mreBCD deletion strain (PA340-678) grew without apparent DNA se...

journal_title：Molecular microbiology

authors： Karczmarek A,Martínez-Arteaga R,Alexeeva S,Hansen FG,Vicente M,Nanninga N,den Blaauwen T

更新日期：2007-07-01 00:00:00

abstract：:Centromere-like loci from bacteria segregate plasmids to progeny cells before cell division. The ParA ATPase (a MinD homologue) of the par2 locus from plasmid pB171 forms oscillating helical structures over the nucleoid. Here we show that par2 distributes plasmid foci regularly along the length of the cell even in cel...

journal_title：Molecular microbiology

authors： Ebersbach G,Ringgaard S,Møller-Jensen J,Wang Q,Sherratt DJ,Gerdes K

更新日期：2006-09-01 00:00:00

abstract：:The structural complexity of a ligand in association with the molecular chaperones SecB and SecA was investigated using three species of precursor maltose-binding protein, which differ in their stability as a result of an amino acid substitution in each that affects the rate of folding of the polypeptide. In the prese...

journal_title：Molecular microbiology

authors： de Cock H,Randall LL

更新日期：1998-01-01 00:00:00

abstract：:Ustilago maydis, the causal agent of corn smut disease, displays dimorphic growth in which it alternates between a budding haploid saprophyte and a filamentous dikaryotic pathogen. We are interested in identifying the genetic determinants of filamentous growth and pathogenicity in U. maydis. To do this, we have taken ...

journal_title：Molecular microbiology

authors： Mayorga ME,Gold SE

更新日期：1999-11-01 00:00:00

abstract：:The Leishmania major aquaglyceroporin, LmAQP1, is responsible for the transport of antimonite [Sb(III)], an activated form of Pentostam or Glucantime. Downregulation of LmAQP1 provides resistance to trivalent antimony compounds and increased expression of LmAQP1 in drug-resistant parasites can reverse the resistance. ...

journal_title：Molecular microbiology

authors： Uzcategui NL,Zhou Y,Figarella K,Ye J,Mukhopadhyay R,Bhattacharjee H

更新日期：2008-12-01 00:00:00

abstract：:Differential gene expression is a key strategy adopted by the Lyme disease spirochaete, Borrelia burgdorferi, for adaptation and survival in the mammalian host and the tick vector. Many B. burgdorferi surface lipoproteins fall into two distinct groups according to their expression patterns: one group primarily express...

journal_title：Molecular microbiology

authors： Wang P,Dadhwal P,Cheng Z,Zianni MR,Rikihisa Y,Liang FT,Li X

更新日期：2013-09-01 00:00:00

abstract：:Genetic approaches can address the question of how integral membrane Sec factors interact with each other and facilitate protein translocation across the cytoplasmic membrane of E. coli. This review summarizes genetic analyses of SecY, SecE and some other protein translocation factors, utilizing 'prl' mutations, 'sec'...

journal_title：Molecular microbiology

authors： Ito K

更新日期：1992-09-01 00:00:00

abstract：:Bacterial spores are surrounded by a multilayered proteinaceous shell called the coat. In Bacillus subtilis, a coat protein called CotE guides the assembly of a major subset of coat proteins. To understand how CotE carries out its role in coat morphogenesis, we subjected its gene to mutagenesis and studied the effects...

journal_title：Molecular microbiology

authors： Little S,Driks A

更新日期：2001-11-01 00:00:00

abstract：:Structural maintenance of chromosome (SMC) and the SMC-interacting kleisin protein families have key functions in the chromosome organization of most organisms. Here, we report that the Bacillus subtilis kleisin, ScpA, can form a ternary complex with the SMC and ScpB proteins in a yeast tri-hybrid assay, supporting th...

journal_title：Molecular microbiology

authors： Dervyn E,Noirot-Gros MF,Mervelet P,McGovern S,Ehrlich SD,Polard P,Noirot P

更新日期：2004-03-01 00:00:00

abstract：:The overall transcription of DNA has previously been demonstrated to proceed at extremely high levels of accuracy. We review the evidence that the process of transcription is subject to proof-reading in the Hopfield sense. In addition, we speculate that the proof-reading activity associated with transcription is subje...

journal_title：Molecular microbiology

authors： Libby RT,Gallant JA

更新日期：1991-05-01 00:00:00

abstract：:Fluorescent polyclonal antibodies specific for MukB have been used to study its localization in Escherichia coli. In wild-type cells, the MukB protein appeared as a limited number of oblong shapes embracing the nucleoid. MukB remained associated with the nucleoid in the absence of DNA replication. The centre of gravit...

journal_title：Molecular microbiology

authors： den Blaauwen T,Lindqvist A,Löwe J,Nanninga N

更新日期：2001-12-01 00:00:00

abstract：:The transcription factor Rex has been implicated in regulation of the expression of genes important for fermentative growth and for growth under conditions of low oxygen tension in several Gram-positive bacteria. Rex senses the redox poise of the cell through changes in the NADH/NAD(+) ratio. The crystal structures of...

journal_title：Molecular microbiology

authors： Wang E,Bauer MC,Rogstam A,Linse S,Logan DT,von Wachenfeldt C

更新日期：2008-07-01 00:00:00

abstract：:Computer analysis of the crystallographic structure of the A subunit of Escherichia coli heat-labile toxin (LT) was used to predict residues involved in NAD binding, catalysis and toxicity. Following site-directed mutagenesis, the mutants obtained could be divided into three groups. The first group contained fully ass...

journal_title：Molecular microbiology

authors： Pizza M,Domenighini M,Hol W,Giannelli V,Fontana MR,Giuliani MM,Magagnoli C,Peppoloni S,Manetti R,Rappuoli R

更新日期：1994-10-01 00:00:00

abstract：:The TonB system of Escherichia coli (TonB/ExbB/ExbD) transduces the protonmotive force (pmf) of the cytoplasmic membrane to drive active transport by high-affinity outer membrane transporters. In this study, chromosomally encoded ExbD formed formaldehyde-linked complexes with TonB, ExbB and itself (homodimers) in vivo...

journal_title：Molecular microbiology

authors： Ollis AA,Manning M,Held KG,Postle K

更新日期：2009-08-01 00:00:00

abstract：:Post-transcriptional repression of porin synthesis has emerged as a major function of Hfq-dependent, small non-coding RNAs (sRNAs). Many enterobacteria express OmpX-like porins, a family of outer membrane proteins whose physiological roles and structural properties have been studied intensively. While regulatory sRNAs...

journal_title：Molecular microbiology

authors： Papenfort K,Pfeiffer V,Lucchini S,Sonawane A,Hinton JC,Vogel J

更新日期：2008-05-01 00:00:00

abstract：:Deletion of gene Rv3676 in Mycobacterium tuberculosis coding for a transcription factor belonging to the cAMP receptor protein (CRP) family caused growth defects in laboratory medium, in bone marrow-derived macrophages and in a mouse model of tuberculosis. Transcript profiling of M. tuberculosis grown in vitro identif...

journal_title：Molecular microbiology

authors： Rickman L,Scott C,Hunt DM,Hutchinson T,Menéndez MC,Whalan R,Hinds J,Colston MJ,Green J,Buxton RS

更新日期：2005-06-01 00:00:00

abstract：:Listeria monocytogenes is an intracellular bacterial pathogen that expresses several surface proteins critical for the infectious process. Such proteins include InlA (internalin) and InlB, involved in bacterial entry into the host cell, and ActA, required for bacterially induced actin-based motility. Although the mole...

journal_title：Molecular microbiology

authors： Braun L,Dramsi S,Dehoux P,Bierne H,Lindahl G,Cossart P

更新日期：1997-07-01 00:00:00

abstract：:In F. graminearum, the transcription factor TRI6 positively regulates the trichothecene biosynthetic gene cluster (BGC) leading to the production of the secondary metabolite 15-acetyl deoxynivalenol. Secondary metabolites are not essential for survival, instead, they enable the pathogen to successfully infect its host...

journal_title：Molecular microbiology

authors： Shostak K,Bonner C,Sproule A,Thapa I,Shields SWJ,Blackwell B,Vierula J,Overy D,Subramaniam R

更新日期：2020-10-01 00:00:00

abstract：:The volume of electron flow through the cbb3 branch of the electron transport chain and the redox state of the quinone pool generate signals that regulate photosynthesis gene expression in Rhodobacter sphaeroides. An inhibitory signal is generated at the level of the catalytic subunit of the cbb3 cytochrome c oxidase ...

journal_title：Molecular microbiology

authors： Oh JI,Kaplan S

更新日期：2001-03-01 00:00:00

abstract：:Helicobacter pylori is a human gastric pathogen associated with gastric and duodenal ulcers as well as gastric cancer. Mounting evidence suggests this pathogen's motility is prerequisite for successful colonization of human gastric tissues. Here, we isolated an H. pylori G27 HP0518 mutant exhibiting altered motility i...

journal_title：Molecular microbiology

authors： Asakura H,Churin Y,Bauer B,Boettcher JP,Bartfeld S,Hashii N,Kawasaki N,Mollenkopf HJ,Jungblut PR,Brinkmann V,Meyer TF

更新日期：2010-12-01 00:00:00

abstract：:The ubiquitous human commensal Escherichia coli has been well investigated through its model representative E. coli K-12. In this work, we initially characterized E. coli Fec10, a recently isolated human commensal strain of phylogroup A/sequence type ST10. Compared to E. coli K-12, the 4.88 Mbp Fec10 genome is charact...

journal_title：Molecular microbiology

authors： Kamal SM,Cimdins-Ahne A,Lee C,Li F,Martín-Rodríguez AJ,Seferbekova Z,Afasizhev R,Wami HT,Katikaridis P,Meins L,Lünsdorf H,Dobrindt U,Mogk A,Römling U

更新日期：2020-09-28 00:00:00

abstract：:During Bacillus subtilis endospore formation, a complex protein coat is assembled around the maturing spore. The coat is made up of more than two dozen proteins that form an outer layer, which provides chemical resistance, and an inner layer, which may play a role in the activation of germination. A third, amorphous l...

journal_title：Molecular microbiology

authors： Seyler RW Jr,Henriques AO,Ozin AJ,Moran CP Jr

更新日期：1997-09-01 00:00:00