Evidence that acetyl phosphate functions as a global signal during biofilm development.

abstract：:Global regulatory circuits of the type mediated by CRP and FNR in Escherichia coli were sought in Lactococcus lactis to provide a basis for redirecting carbon metabolism to specific fermentation products. Using a polymerase chain reaction (PCR) approach, two genes (flpA and flpB) encoding FNR-like proteins (FlpA and F...

journal_title：Molecular microbiology

authors： Gostick DO,Griffin HG,Shearman CA,Scott C,Green J,Gasson MJ,Guest JR

更新日期：1999-03-01 00:00:00

abstract：:Establishment of an axis of cell polarity and differentiation of the cell poles are fundamental aspects of cellular development in many organisms. We compared the effects of two bacterial cytoskeletal-like systems, the MreB and MinCDE systems, on these processes in Escherichia coli. We report that the Min proteins are...

journal_title：Molecular microbiology

authors： Shih YL,Kawagishi I,Rothfield L

更新日期：2005-11-01 00:00:00

abstract：:The Escherichia coli rodA and ftsW genes and the spoVE gene of Bacillus subtilis encode membrane proteins that control peptidoglycan synthesis during cellular elongation, division and sporulation respectively. While rodA and ftsW are essential genes in E. coli, the B. subtilis spoVE gene is dispensable for growth and ...

journal_title：Molecular microbiology

authors： Henriques AO,Glaser P,Piggot PJ,Moran CP Jr

更新日期：1998-04-01 00:00:00

abstract：:Candida albicans hyphae grow in a highly polarized fashion from their tips. This polarized growth requires the continuous delivery of secretory vesicles to the tip region. Vesicle delivery depends on Sec2p, the Guanine Exchange Factor (GEF) for the Rab GTPase Sec4p. GTP bound Sec4p is required for the transit of secre...

journal_title：Molecular microbiology

authors： Caballero-Lima D,Hautbergue GM,Wilson SA,Sudbery PE

更新日期：2014-11-01 00:00:00

abstract：:In Escherichia coli, the SeqA protein is known as a negative regulator of chromosome replication. This protein is also suggested to have a role in chromosome organization. SeqA preferentially binds to hemi-methylated DNA and is by immunofluorescence microscopy seen as foci situated at the replication factories. Loss o...

journal_title：Molecular microbiology

authors： Klungsøyr HK,Skarstad K

更新日期：2004-10-01 00:00:00

abstract：:Although the aerobic degradation of aromatic compounds has been extensively studied in many microorganisms, the anaerobic mineralization of the aromatic ring is a more recently discovered microbial capacity on which very little information is available from facultative anaerobic bacteria. In this issue of Molecular Mi...

journal_title：Molecular microbiology

authors： Carmona M,Díaz E

更新日期：2005-12-01 00:00:00

abstract：:The S box transcription termination control system regulates expression of genes involved in methionine metabolism. Expression of the S box regulon, comprised of 11 transcriptional units in Bacillus subtilis, is induced in response to starvation for methionine. We previously demonstrated that S-adenosylmethionine (SAM...

journal_title：Molecular microbiology

authors： McDaniel BA,Grundy FJ,Henkin TM

更新日期：2005-08-01 00:00:00

abstract：:Eeyarestatin 1 (ES1) is an inhibitor of endoplasmic reticulum (ER) associated protein degradation, Sec61-dependent Ca2+ homeostasis and protein translocation into the ER. Recently, evidence was presented showing that a smaller analog of ES1, ES24, targets the Sec61-translocon, and captures it in an open conformation t...

journal_title：Molecular microbiology

authors： Steenhuis M,Koningstein GM,Oswald J,Pick T,O'Keefe S,Koch HG,Cavalié A,Whitehead RC,Swanton E,High S,Luirink J

更新日期：2020-08-15 00:00:00

abstract：:The tra operon of the prototypical F plasmid and its relatives enables transfer of a copy of the plasmid to other bacterial cells via the process of conjugation. Tra proteins assemble to form the transferosome, the transmembrane pore through which the DNA is transferred, and the relaxosome, a complex of DNA-binding pr...

journal_title：Molecular microbiology

authors： Wong JJ,Lu J,Glover JN

更新日期：2012-08-01 00:00:00

abstract：:The Staphylococcus epidermidis genes icaABC are involved in the synthesis of the polysaccharide intercellular adhesin (PIA), which is located mainly on the cell surface, as shown by immunofluorescence studies with PIA-specific antiserum. PIA was shown to be a linear beta-1,6-linked glucosaminoglycan composed of at lea...

journal_title：Molecular microbiology

authors： Heilmann C,Schweitzer O,Gerke C,Vanittanakom N,Mack D,Götz F

更新日期：1996-06-01 00:00:00

abstract：:Type II restriction enzymes are paired with modification enzymes that protect type II restriction sites from cleavage by methylating them. A plasmid carrying a type II restriction-modification gene complex is not easily replaced by an incompatible plasmid because loss of the former leads to cell death through chromoso...

journal_title：Molecular microbiology

authors： Handa N,Nakayama Y,Sadykov M,Kobayashi I

更新日期：2001-05-01 00:00:00

abstract：:Myxococcus xanthus is a Gram-negative bacterium capable of complex developmental processes involving vegetative swarming and fruiting body formation. Social (S-) gliding motility, one of the two motility systems used by M. xanthus, requires at least two cell surface structures: type IV pili (TFP) and extracellular pol...

journal_title：Molecular microbiology

authors： Yang Z,Lux R,Hu W,Hu C,Shi W

更新日期：2010-06-01 00:00:00

abstract：:We have found a simple relationship between bacterial growth rate and the translation elongation rate. Thus, for a set of defined ribosomal protein S12 mutations which reduce the efficiency of the ternary complex ribosome interaction (and restrict the frequency of translational errors) there is a linear relationship b...

journal_title：Molecular microbiology

authors： Tubulekas I,Hughes D

更新日期：1993-01-01 00:00:00

abstract：:Accumulation of stalled ribosomes at the 3' end of mRNA without a stop codon (non-stop mRNA) is supposed to be toxic to bacterial cells. Escherichia coli has at least two distinct systems to rescue such stalled ribosomes: SsrA-dependent trans-translation and ArfA-dependent ribosome rescue. Combination of the ssrA and ...

journal_title：Molecular microbiology

authors： Chadani Y,Ono K,Kutsukake K,Abo T

更新日期：2011-05-01 00:00:00

abstract：:Biofilm formation is a social behaviour that generates favourable conditions for sustained survival in the natural environment. For the Gram-positive bacterium Bacillus subtilis the process involves the differentiation of cell fate within an isogenic population and the production of communal goods that form the biofil...

journal_title：Molecular microbiology

authors： Cairns LS,Hobley L,Stanley-Wall NR

更新日期：2014-08-01 00:00:00

abstract：:The inv locus of Yersinia enterocolitica is sufficient to convert a non-invasive Escherichia coli K12 strain into a microorganism that is able to penetrate cultured mammalian cells. The nucleotide sequence of inv reveals an open reading frame corresponding to an 835-amino-acid protein that is homologous to the invasin...

journal_title：Molecular microbiology

authors： Young VB,Miller VL,Falkow S,Schoolnik GK

更新日期：1990-07-01 00:00:00

abstract：:We previously identified three well-dispersed mutations, E978-K, F989-L and D1009-R within the haemolysin A signal region, located at positions -46, -35 and -15, with respect to the C-terminus, respectively. Each mutation reduces the efficiency of secretion two- to threefold leaving 30-45% of the wild-type activity. W...

journal_title：Molecular microbiology

authors： Kenny B,Chervaux C,Holland IB

更新日期：1994-01-01 00:00:00

abstract：:Through trans-splicing of a 39-nt spliced leader (SL) onto each protein-coding transcript, mature kinetoplastid mRNA acquire a hypermethylated 5'-cap structure, but its function has been unclear. Gene deletions for three Trypanosoma brucei cap 2'-O-ribose methyltransferases, TbMTr1, TbMTr2 and TbMTr3, reveal distinct ...

journal_title：Molecular microbiology

authors： Zamudio JR,Mittra B,Campbell DA,Sturm NR

更新日期：2009-06-01 00:00:00

abstract：:Choline-binding proteins (CBPs) from Streptococcus pneumoniae are involved in several important processes. Inactivation of zmpB, a gene that encodes a surface-located putative zinc metalloprotease, in a S. pneumoniae serotype 4 strain was recently reported to reveal a composite phenotype, including extensive chain for...

journal_title：Molecular microbiology

authors： Bergé M,García P,Iannelli F,Prère MF,Granadel C,Polissi A,Claverys JP

更新日期：2001-03-01 00:00:00

abstract：:Understanding the basis of bacterial persistence in latent infections is critical for eradication of tuberculosis. Analysis of Mycobacterium tuberculosis mRNA expression in an in vitro model of non-replicating persistence indicated that the bacilli require electron transport chain components and ATP synthesis for surv...

journal_title：Molecular microbiology

authors： Dhiman RK,Mahapatra S,Slayden RA,Boyne ME,Lenaerts A,Hinshaw JC,Angala SK,Chatterjee D,Biswas K,Narayanasamy P,Kurosu M,Crick DC

更新日期：2009-04-01 00:00:00

abstract：:bfp, the structural gene of the major repeating bundle-forming pilus (BFP) subunit, was cloned from the enteroadherent factor (EAF) plasmid of enteropathogenic Escherichia coli (EPEC) strain B171 (O111:NM). The bfp open reading frame encoded a 193-amino-acid protein; comparison of this sequence with the biochemically ...

journal_title：Molecular microbiology

authors： Sohel I,Puente JL,Murray WJ,Vuopio-Varkila J,Schoolnik GK

更新日期：1993-02-01 00:00:00

abstract：:Transcription of flagellar genes in Caulobacter crecentus is programmed to occur during the predivisional stage of the cell cycle. The mechanism of activation of Class II flagellar genes, the highest identified genes in the Caulobacter flagellar hierarchy, is unknown. As a step toward understanding this process, we ha...

journal_title：Molecular microbiology

authors： Stephens CM,Shapiro L

更新日期：1993-09-01 00:00:00

abstract：:Alternative oxidase (AOX) is a respiratory oxidase found in certain eukaryotes and bacteria; however, its role in bacterial physiology is unclear. Exploiting the genetic tractability of the bacterium Vibrio fischeri, we explore the regulation of aox expression and AOX function. Using quantitative PCR and reporter assa...

journal_title：Molecular microbiology

authors： Dunn AK,Karr EA,Wang Y,Batton AR,Ruby EG,Stabb EV

更新日期：2010-07-01 00:00:00

abstract：:The osteolytic toxin of Pasteurella multocida induces bone resorption in vivo and in vitro (Foged et al., 1988; Kimman et al., 1987). In this report the toxin-encoding toxA gene is sequenced, and the deduced primary structure of the toxin shows a protein of 1285 amino acids, containing a striking homology to a metal-b...

journal_title：Molecular microbiology

authors： Petersen SK

更新日期：1990-05-01 00:00:00

abstract：:Replication of the bacterial chromosome is initiated by the binding of the DnaA protein to a unique DNA region, called oriC. Many regulatory factors in numerous species act by controlling the ability of DnaA to bind and unwind DNA, but the Helicobacter pylori genome does not contain homologues to any of these factors....

journal_title：Molecular microbiology

authors： Zawilak-Pawlik A,Kois A,Stingl K,Boneca IG,Skrobuk P,Piotr J,Lurz R,Zakrzewska-Czerwińska J,Labigne A

更新日期：2007-08-01 00:00:00

abstract：:Genetic approaches can address the question of how integral membrane Sec factors interact with each other and facilitate protein translocation across the cytoplasmic membrane of E. coli. This review summarizes genetic analyses of SecY, SecE and some other protein translocation factors, utilizing 'prl' mutations, 'sec'...

journal_title：Molecular microbiology

authors： Ito K

更新日期：1992-09-01 00:00:00

abstract：:For malaria to be transmitted, the Plasmodium falciparum parasite must invade an erythrocyte and undergo gametocytogenesis. When mature intraerythrocytic gametocytes are taken up in a blood meal by a mosquito they emerge as gametes and, once fertilized, continue to differentiate into infectious sporozoites. One of the...

journal_title：Molecular microbiology

authors： Eksi S,Stump A,Fanning SL,Shenouda MI,Fujioka H,Williamson KC

更新日期：2002-06-01 00:00:00

abstract：:The Salmonella flagellar motor consists of a rotor and about a dozen stator elements. Each stator element, consisting of MotA and MotB, acts as a proton channel to couple proton flow with torque generation. A highly conserved Asp33 residue of MotB is directly involved in the energy coupling mechanism, but it remains u...

journal_title：Molecular microbiology

authors： Che YS,Nakamura S,Morimoto YV,Kami-Ike N,Namba K,Minamino T

更新日期：2014-01-01 00:00:00

abstract：:The replication origin of the broad-host-range plasmid RK2, oriV, contains four DnaA boxes, which bind the DnaA protein isolated from Escherichia coli. Using a transformation assay, mutational analysis of these boxes showed a differential requirement for replication in different Gram-negative bacteria. DnaA boxes 3 an...

journal_title：Molecular microbiology

authors： Doran KS,Helinski DR,Konieczny I

更新日期：1999-08-01 00:00:00

abstract：:Francisella tularensis are the causative agent of the zoonotic disease, tularaemia. Among four F. tularensis subspecies, ssp. novicida (F. novicida) is pathogenic only for immunocompromised individuals, while all four subspecies are pathogenic for mice. This study utilized proteomic and bioinformatic approaches to ide...

journal_title：Molecular microbiology

authors： Hager AJ,Bolton DL,Pelletier MR,Brittnacher MJ,Gallagher LA,Kaul R,Skerrett SJ,Miller SI,Guina T

更新日期：2006-10-01 00:00:00