Type IV pili-mediated secretion modulates Francisella virulence.

abstract：:Chlamydia is predicted to encode two alternative sigma factors that could provide a mechanism for the regulation of gene expression via alternative forms of RNA polymerase. We have demonstrated that sigma 28, one of these alternative sigma factors, is transcriptionally active. Chlamydial sigma 28 RNA polymerase was re...

journal_title：Molecular microbiology

authors： Yu HH,Tan M

更新日期：2003-10-01 00:00:00

abstract：:The heterotrimeric G-protein pathway is a ubiquitous eukaryotic signalling module that is known to regulate growth and differentiation in many plant pathogens. We previously identified Pigpa1, a gene encoding a G-protein alpha subunit from the potato late blight pathogen Phytophthora infestans. P. infestans belongs to...

journal_title：Molecular microbiology

authors： Latijnhouwers M,Ligterink W,Vleeshouwers VG,van West P,Govers F

更新日期：2004-02-01 00:00:00

abstract：:The bacterium Burkholderia glumae causes rice grain rot by producing toxoflavin, whose expression is regulated by quorum sensing (QS). We report a major deviation from the current paradigm for the regulation of bacterial polar flagellum genes. The N-octanoyl homoserine lactone (C8-HSL)-deficient mutant of B. glumae is...

journal_title：Molecular microbiology

authors： Kim J,Kang Y,Choi O,Jeong Y,Jeong JE,Lim JY,Kim M,Moon JS,Suga H,Hwang I

更新日期：2007-04-01 00:00:00

abstract：:Myxococcus xanthus is a Gram-negative bacterium capable of complex developmental processes involving vegetative swarming and fruiting body formation. Social (S-) gliding motility, one of the two motility systems used by M. xanthus, requires at least two cell surface structures: type IV pili (TFP) and extracellular pol...

journal_title：Molecular microbiology

authors： Yang Z,Lux R,Hu W,Hu C,Shi W

更新日期：2010-06-01 00:00:00

abstract：:Biofilms are communities of microbial cells that are encased in a self-produced, polymeric matrix and are adherent to a surface. For several species of bacteria, an enhanced ability to form biofilms has been linked with an increased capability to produce exopolymers. To identify exopolymers of Bacillus subtilis that c...

journal_title：Molecular microbiology

authors： Stanley NR,Lazazzera BA

更新日期：2005-08-01 00:00:00

abstract：:There is a DNA sequence which has unusually high affinity for the DnaA protein of Escherichia coli between the glyV and amiB-mutL operons at 94.7 min on the genetic map. Affinity of DnaA protein for DNA was measured in vivo as the activity of beta-galactosidase produced from the lacZ gene on a plasmid fused to the 5'-...

journal_title：Molecular microbiology

authors： Kitagawa R,Mitsuki H,Okazaki T,Ogawa T

更新日期：1996-03-01 00:00:00

abstract：:Pathogenic strains of Yersinia deploy a type III secretion system to inject the potent tyrosine phosphatase YopH into host cells, where it dephosphorylates focal adhesion-associated substrates. The amino-terminal, non-catalytic domain of YopH is bifunctional; it is essential for the secretion and binding of the specif...

journal_title：Molecular microbiology

authors： Smith CL,Khandelwal P,Keliikuli K,Zuiderweg ER,Saper MA

更新日期：2001-11-01 00:00:00

abstract：:The essential proteins DnaB, DnaD and DnaI of Bacillus subtilis are required for initiation, but not elongation, of DNA replication, and for replication restart at stalled forks. The interactions and functions of these proteins have largely been determined in vitro based on their roles in replication restart. During r...

journal_title：Molecular microbiology

authors： Smits WK,Goranov AI,Grossman AD

更新日期：2010-01-01 00:00:00

abstract：:In clinical isolates of Enterobacter cloacae, resistance to the newer beta-lactam antibiotics often results from overproduction of a cephalosporinase encoded by the beta-lactam-inducible ampC gene. Regulation of ampC is controlled by the divergently expressed activator gene, ampR, and a second unlinked locus. In this ...

journal_title：Molecular microbiology

authors： Honoré N,Nicolas MH,Cole ST

更新日期：1989-08-01 00:00:00

abstract：:The differences between archaeal and bacterial flagella are becoming more apparent as research on the archaeal structure progresses. One crucial difference is the presence of a leader peptide on archaeal preflagellins, which is removed from the flagellin prior to its incorporation into the flagellar filament. The enzy...

journal_title：Molecular microbiology

authors： Bardy SL,Jarrell KF

更新日期：2003-11-01 00:00:00

abstract：:In Escherichia coli, RecA protein regulates the DNA damage-inducible survival-enhancing SOS response. Mutant allele recA730, which causes constitutive SOS expression, is lethal at high temperatures in B/r, a derivative of wild-type B, but not in K-12 or in certain B/r--K-12 hybrids. We present evidence that killing is...

journal_title：Molecular microbiology

authors： Kirchner J,Lim D,Witkin EM,Garvey N,Roegner-Maniscalco V

更新日期：1992-10-01 00:00:00

abstract：:Cell differentiation is widespread during the development of multicellular organisms, but rarely observed in prokaryotes. One example of prokaryotic differentiation is the gram-negative bacterium Myxococcus xanthus. In response to starvation, this gliding bacterium initiates a complex developmental programme that resu...

journal_title：Molecular microbiology

authors： Hoiczyk E,Ring MW,McHugh CA,Schwär G,Bode E,Krug D,Altmeyer MO,Lu JZ,Bode HB

更新日期：2009-10-01 00:00:00

abstract：:The human stomach pathogen Helicobacter pyloriattaches to healthy and inflamed gastric tissue through members of a paralogous family of 'Helicobacter outer membrane proteins' (Hops), including adhesins BabA, SabA, HopQ, LabA and HopZ. Hops share a conserved 25 kDa C-terminal region that is thought to form an autotrans...

journal_title：Molecular microbiology

authors： Coppens F,Castaldo G,Debraekeleer A,Subedi S,Moonens K,Lo A,Remaut H

更新日期：2018-10-01 00:00:00

abstract：:Plasmodium parasites possess a single pyruvate dehydrogenase (PDH) enzyme complex that is localized to the plastid-like organelle known as the apicoplast. Unlike most eukaryotes, Plasmodium parasites lack a mitochondrial PDH. The PDH complex catalyses the conversion of pyruvate to acetyl-CoA, an important precursor fo...

journal_title：Molecular microbiology

authors： Pei Y,Tarun AS,Vaughan AM,Herman RW,Soliman JM,Erickson-Wayman A,Kappe SH

更新日期：2010-02-01 00:00:00

abstract：:Bacterial cytokinesis is orchestrated by an assembly of essential cell division proteins that form a supramolecular structure known as the divisome. DivIB and its orthologue FtsQ are essential members of the divisome in Gram-positive and Gram-negative bacteria respectively. DivIB is a bitopic membrane protein composed...

journal_title：Molecular microbiology

authors： Wadsworth KD,Rowland SL,Harry EJ,King GF

更新日期：2008-03-01 00:00:00

abstract：:Molecular analyses were applied to the genes encoding variants of the serosubtyping antigen, the class 1 outer membrane protein (PorA), from 55 serogroup A Neisseria meningitidis strains. These genes were evolutionarily stable and exhibited a limited range of genetic variation, primarily generated by recombination. Tr...

journal_title：Molecular microbiology

authors： Suker J,Feavers IM,Achtman M,Morelli G,Wang JF,Maiden MC

更新日期：1994-04-01 00:00:00

abstract：:The opportunistic pathogen Pseudomonas aeruginosa produces type 4 fimbriae which promote adhesion to epithelial cells and are associated with a form of surface translocation called twitching motility. Transposon mutagenesis was used to identify loci required for fimbrial assembly or function by screening for mutants t...

journal_title：Molecular microbiology

authors： Martin PR,Watson AA,McCaul TF,Mattick JS

更新日期：1995-05-01 00:00:00

abstract：:The Bacillus thuringiensis insecticidal crystal protein CryIIA has both high mosquito activity and gypsy moth activity; in contrast CryIIB, which is 87% homologous, displays no mosquito activity and has a three-fold lower gypsy moth activity. The regions responsible for specificity against gypsy moth (Lymantria dispar...

journal_title：Molecular microbiology

authors： Liang Y,Dean DH

更新日期：1994-08-01 00:00:00

abstract：:Lipids are essential structural constituents of bacterial cell membranes and walls, and their biosynthetic pathways are stringently regulated at both biochemical and genetic levels. The recent surge of new information about transcriptional regulation of bacterial lipid metabolism is highlighted by two studies in this ...

journal_title：Molecular microbiology

authors： Zhang YM,Rock CO

更新日期：2010-10-01 00:00:00

abstract：:The Pseudomonas aeruginosa protein PtxS negatively regulates its own synthesis by binding to the upstream region of its gene. We have recently identified a 14 bp palindromic sequence within the ptxS upstream region as the PtxS operator site (OP1). In this study, we searched the P. aeruginosa genomic sequence to determ...

journal_title：Molecular microbiology

authors： Swanson BL,Hager P,Phibbs P Jr,Ochsner U,Vasil ML,Hamood AN

更新日期：2000-08-01 00:00:00

abstract：:This past January, in Cuernavaca Mexico, a conglomerate of scientists met to discuss the contemporary view of Bacterial Locomotion and Signal Transduction (BLAST). The BLAST meetings represent a field that has its roots in chemotaxis and the flagellum-based motility but now encompass all types of cellular movement and...

journal_title：Molecular microbiology

authors： Scharf BE,Aldridge PD,Kirby JR,Crane BR

更新日期：2009-07-01 00:00:00

abstract：:Poly(A) polymerase I (PAP I) of Escherichia coli is a member of the nucleotidyltransferase (Ntr) superfamily that includes the eukaryotic PAPs and all the known tRNA CCA-adding enzymes. Five highly conserved aspartic acids in the putative catalytic site of PAP I were changed to either alanine or proline, demonstrating...

journal_title：Molecular microbiology

authors： Raynal LC,Carpousis AJ

更新日期：1999-05-01 00:00:00

abstract：:Early diverged extant organisms, which may serve as convenient laboratory models to look for and study evolutionary ancient features of eukaryotic cell biology, are rare. The diplomonad Giardia intestinalis, a protozoan parasite known to cause diarrhoeal disease, has become an increasingly popular object of basic rese...

journal_title：Molecular microbiology

authors： Hehl AB,Marti M

更新日期：2004-07-01 00:00:00

abstract：:The recent development of specific probes for lipid molecules has led to the discovery of lipid domains in bacterial membranes, that is, of membrane areas differing in lipid composition. A view of the membrane as a patchwork is replacing the assumption of lipid homogeneity inherent in the fluid mosaic model of Singer ...

journal_title：Molecular microbiology

authors： Matsumoto K,Kusaka J,Nishibori A,Hara H

更新日期：2006-09-01 00:00:00

abstract：:Regulation of DNA replication in Bacillus subtilis involves a post-initiation mechanism which is subject to control by the Stringent System, an essential regulatory network, mediated by the alarmone, ppGpp. In detailed studies using DNA-DNA hybridization procedures, we have now shown that, following the induction of t...

journal_title：Molecular microbiology

authors： Levine A,Autret S,Séror SJ

更新日期：1995-01-01 00:00:00

abstract：:In this issue of Molecular Microbiology, Rugarabamu and colleagues investigate the role of rhomboid proteases responsible for adhesin shedding during invasion of the apicomplexan parasite Toxoplasma gondii. This study, together with several other recent publications, raises new questions about the function of these rh...

journal_title：Molecular microbiology

authors： Stewart RJ,Tonkin CJ

更新日期：2015-07-01 00:00:00

abstract：:The production of the bacterial DNA replication inhibitor Microcin B17 is induced as cultures enter stationary phase. Using S1 nuclease protection assays we have shown that this induction is the result of increased levels of transcription initiation from a promoter located upstream from mcbA, the structural gene for M...

journal_title：Molecular microbiology

authors： Connell N,Han Z,Moreno F,Kolter R

更新日期：1987-09-01 00:00:00

abstract：:In Escherichia coli, after DNA damage, the SOS response increases the transcription (and protein levels) of approximately 50 genes. As DNA repair ensues, the level of transcription returns to homeostatic levels. ClpXP and other proteases return the high levels of several SOS proteins to homeostasis. When all SOS genes...

journal_title：Molecular microbiology

authors： Warr AR,Klimova AN,Nwaobasi AN,Sandler SJ

更新日期：2019-02-01 00:00:00

abstract：:Transposon mutagenesis was used to isolate insertion mutants of the photosynthetic bacterium Rhodobacter capsulatus which were unable to grow under aerobic conditions in the dark on malate, succinate or fumarate as sole carbon sources. Of five mutants isolated, all were deficient in C4-dicarboxylate transport. However...

journal_title：Molecular microbiology

authors： Hamblin MJ,Shaw JG,Curson JP,Kelly DJ

更新日期：1990-09-01 00:00:00

abstract：:Plasmodium vivax is one of four Plasmodium species that cause human malaria. P. vivax and a related simian malaria parasite, Plasmodium knowlesi, invade erythrocytes by binding the Duffy antigen/receptor for chemokines (DARC) through their respective Duffy binding proteins. Here we show that tyrosines 30 and 41 of DAR...

journal_title：Molecular microbiology

authors： Choe H,Moore MJ,Owens CM,Wright PL,Vasilieva N,Li W,Singh AP,Shakri R,Chitnis CE,Farzan M

更新日期：2005-03-01 00:00:00