Secretory protein trafficking in Giardia intestinalis.

abstract：:Lactose is an abundant dietary carbohydrate metabolized by the dental pathogen Streptococcus mutans. Lactose metabolism presents both classic diauxic behaviors and long-term memory, where the bacteria can pause for >11 h before initiating growth on lactose. Here, we explored mechanisms contributing to unusual aspects ...

journal_title：Molecular microbiology

authors： Zeng L,Burne RA

更新日期：2020-09-03 00:00:00

abstract：:Carbapenems such as meropenem are being investigated for their potential therapeutic utility against highly drug-resistant tuberculosis. These β-lactams target the transpeptidases that introduce interpeptide cross-links into bacterial peptidoglycan thereby controlling rigidity of the bacterial envelope. Treatment of M...

journal_title：Molecular microbiology

authors： Kumar P,Arora K,Lloyd JR,Lee IY,Nair V,Fischer E,Boshoff HI,Barry CE 3rd

更新日期：2012-10-01 00:00:00

abstract：:Helicobacter pylori is a human gastric pathogen that colonizes ∼ 50% of the world's population. It can cause gastritis, gastric or duodenal ulcers and also gastric cancer. The numerous side effects of available treatments and the emergence of antibiotic resistant strains are severe concerns that justify further resear...

journal_title：Molecular microbiology

authors： Lester J,Kichler S,Oickle B,Fairweather S,Oberc A,Chahal J,Ratnayake D,Creuzenet C

更新日期：2015-04-01 00:00:00

abstract：:Induction of the sugar-phosphate transport system in Escherichia coli by external glucose-6-phosphate is regulated by the UhpABC regulatory proteins. UhpA protein is required for uhpT transcription and is related to response regulators of two-component regulatory systems. UhpA and its homologues appear to be composed ...

journal_title：Molecular microbiology

authors： Webber CA,Kadner RJ

更新日期：1995-03-01 00:00:00

abstract：:Two so-called Ter sites, which bind the Escherichia coli Tus protein, are located near the replication origin of plasmid R1. Inactivation of the tus gene caused a large decrease in the stability of maintenance of the R1 mini-derivative pOU47 despite the presence of a functional partition system on the plasmid. Deletio...

journal_title：Molecular microbiology

authors： Krabbe M,Zabielski J,Bernander R,Nordström K

更新日期：1997-05-01 00:00:00

abstract：:In nature, organic acids are a commonly used source of carbon and energy. Many bacteria use AMP-forming acid:CoA ligases to convert organic acids into their corresponding acyl-CoA derivatives, which can then enter metabolism. The soil environment contains a broad diversity of organic acids, so it is not surprising tha...

journal_title：Molecular microbiology

authors： Burckhardt RM,VanDrisse CM,Tucker AC,Escalante-Semerena JC

更新日期：2020-01-01 00:00:00

abstract：:Sinorhizobium meliloti and host legumes enter into a nitrogen-fixing, symbiotic relationship triggered by an exchange of signals between bacteria and plant. S. meliloti produces Nod factor, which elicits the formation of nodules on plant roots, and succinoglycan, an exopolysaccharide that allows for bacterial invasion...

journal_title：Molecular microbiology

authors： Wells DH,Long SR

更新日期：2002-03-01 00:00:00

abstract：:Glutathione (GSH) is an abundant low-molecular-mass thiol which has been implicated in numerous cellular processes including protection against cytotoxic agents such as xenobiotics, carcinogens and free radicals. Utilization of GSH results in its conversion to the oxidized form (GSSG), and it is recycled to GSH by the...

journal_title：Molecular microbiology

authors： Grant CM,Maciver FH,Dawes IW

更新日期：1996-11-01 00:00:00

abstract：:In bacteria, genes are often expressed from multiple promoters to allow for a greater spectrum of regulation. Transcription of rRNA genes in Escherichia coli uses two promoters, rrn P1 and rrn P2. Under the conditions examined previously, the P1 and P2 promoters were regulated in response to many of the same changes i...

journal_title：Molecular microbiology

authors： Murray HD,Gourse RL

更新日期：2004-06-01 00:00:00

abstract：:Several bacterial genera express proteins that contain collagen-like regions, which are associated with variable (V) non-collagenous regions. The streptococcal collagen-like proteins, Scl1 and Scl2, of group A Streptococcus (GAS) are members of this 'prokaryotic collagen' family, and they too contain an amino-terminal...

journal_title：Molecular microbiology

authors： Han R,Caswell CC,Lukomska E,Keene DR,Pawlowski M,Bujnicki JM,Kim JK,Lukomski S

更新日期：2006-07-01 00:00:00

abstract：:Stimulation of Escherichia coli with acetate elevates the acetylation level of the chemotaxis response regulator CheY. This elevation, in an unknown mechanism, activates CheY to generate clockwise rotation. Here, using quantitative selective reaction monitoring mass spectrometry and high-resolution targeted mass spect...

journal_title：Molecular microbiology

authors： Fraiberg M,Afanzar O,Cassidy CK,Gabashvili A,Schulten K,Levin Y,Eisenbach M

更新日期：2015-01-01 00:00:00

abstract：:Many bacterial gene regulatory circuits are controlled by temperature. Temperature-mediated regulation occurs at the level of transcription and translation. Supercoiling, changes in mRNA conformation and protein conformation are all implicated in thermosensing. Bacterial virulence functions are often temperature regul...

journal_title：Molecular microbiology

authors： Hurme R,Rhen M

更新日期：1998-10-01 00:00:00

abstract：:Previous work demonstrated that selection for Escherichia coli mutants with low antibiotic resistance frequently resulted in co-selection of lon mutations and that lon(-) mutants evolved higher-level resistance faster than a lon(+) strain. Here we show that lon mutation causes a very low multidrug resistance by induci...

journal_title：Molecular microbiology

authors： Nicoloff H,Andersson DI

更新日期：2013-12-01 00:00:00

abstract：:The Helicobacter pylori genome contains a gene (hp1338 or nikR) that encodes a nickel-dependent regulator that is homologous to the Escherichia coli nickel-responsive regulator, NikR. The H. pylori nikR product acts as a pleiotropic metal-dependent regulator. We constructed a non-polar isogenic mutant deleted for the ...

journal_title：Molecular microbiology

authors： Contreras M,Thiberge JM,Mandrand-Berthelot MA,Labigne A

更新日期：2003-08-01 00:00:00

abstract：:Bacteria retain certain proteins at their cell envelopes by attaching them in a non-covalent manner to peptidoglycan, using specific protein domains, such as the prominent LysM (Lysin Motif) domain. More than 4000 (Pfam PF01476) proteins of both prokaryotes and eukaryotes have been found to contain one or more Lysin M...

journal_title：Molecular microbiology

authors： Buist G,Steen A,Kok J,Kuipers OP

更新日期：2008-05-01 00:00:00

abstract：:The collective function of secreted pathogen effector molecules is to enhance the virulence and avirulence activity of the pathogen during the infection of its host. While the activity of a majority of pathogen effectors is unknown, several classes of effector molecules have been well characterized. Among these includ...

journal_title：Molecular microbiology

authors： Tian M,Day B

更新日期：2006-09-01 00:00:00

abstract：:Conjugative transfer of toxin and antibiotic resistance plasmids in Clostridium perfringens is mediated by the tcp conjugation locus. Surprisingly, neither a relaxase gene nor an origin of transfer (oriT) has been identified on these plasmids, which are typified by the 47 kb tetracycline resistance plasmid pCW3. The t...

journal_title：Molecular microbiology

authors： Wisniewski JA,Traore DA,Bannam TL,Lyras D,Whisstock JC,Rood JI

更新日期：2016-03-01 00:00:00

abstract：:The cytochrome d complex of Escherichia coli is a heterodimer located in the bacterial cytoplasmic membrane, where it functions as a terminal oxidase of the aerobic respiratory chain. The topology of each of the two subunits of the cytochrome d complex was analysed by the genetic method involving alkaline phosphatase ...

journal_title：Molecular microbiology

authors： Newton G,Yun CH,Gennis RB

更新日期：1991-10-01 00:00:00

abstract：:Candida albicans is an opportunistic yeast that can cause life-threatening systemic infection in immunocompromised individuals. During infections, C. albicans has to cope with genotoxic stresses generated by the host immune system. DNA-protein crosslink (DPC), the covalent linkage of proteins with DNA, is one type of ...

journal_title：Molecular microbiology

authors： Homchan A,Sukted J,Mongkolsuk S,Jeruzalmi D,Matangkasombut O,Pakotiprapha D

更新日期：2020-09-01 00:00:00

abstract：:Soupene et al. [J. Bacteriol. (2003) 185 5611-5626] made the unexpected observation that the presence of a mutation, in the gene for the N-acetylglucosamine repressor, nagC, increased the growth rate of Escherichia coli MG1655 on galactose, an unrelated sugar. We have found that NagC, binds to a single, high-affinity ...

journal_title：Molecular microbiology

authors： El Qaidi S,Allemand F,Oberto J,Plumbridge J

更新日期：2009-01-01 00:00:00

abstract：:The Clostridium difficile toxA and toxB genes, encoding cytotoxic and enterotoxic proteins responsible for antibiotic-associated colitis and pseudomembranous colitis, were shown to be transcribed both from gene-specific promoters and from promoters of upstream genes. However, the gene-specific transcripts represented ...

journal_title：Molecular microbiology

authors： Dupuy B,Sonenshein AL

更新日期：1998-01-01 00:00:00

abstract：:The DNA sequence of the structural gene (yopE) of one of the Yersinia pseudotuberculosis virulence plas-mid-plB1-encoded proteins, Yop5, is presented. The deduced protein showed a molecular weight of 22971 Daltons. A specific mutant, having a kanamycin-resistance fragment inserted within the yopE gene was no longer vi...

journal_title：Molecular microbiology

authors： Forsberg A,Wolf-Watz H

更新日期：1988-01-01 00:00:00

abstract：:Comparison of the Leishmania infantum genome with Leishmania braziliensis and Leishmania major genomes has identified 25 L. infantum species-specific genes that are absent or pseudogenes in L. major and L. braziliensis. To determine whether these L. infantum species-specific genes are involved in visceral Leishmania i...

journal_title：Molecular microbiology

authors： Zhang WW,Matlashewski G

更新日期：2010-07-01 00:00:00

abstract：:SpsA, a pneumococcal surface protein belonging to the family of choline-binding proteins, interacts specifically with secretory immunglobulin A (SIgA) via the secretory component (SC). SIgA and free SC from mouse, rat, rabbit and guinea-pig failed to interact with SpsA indicating species-specific binding to human SIgA...

journal_title：Molecular microbiology

authors： Hammerschmidt S,Tillig MP,Wolff S,Vaerman JP,Chhatwal GS

更新日期：2000-05-01 00:00:00

abstract：:Despite their high genomic synteny, the Leishmania major and Leishmania infantum species exhibit extensive differences in mRNA expression patterns throughout the parasite's development. Yet, the underlying mechanisms for this species-specific differential gene expression are largely unknown. Here we report that Short ...

journal_title：Molecular microbiology

authors： Müller M,Padmanabhan PK,Papadopoulou B

更新日期：2010-07-01 00:00:00

abstract：:The cell wall is considered an essential component for bacterial survival, providing structural support, and protection from environmental insults. Under normal growth conditions, filamentous actinobacteria insert new cell wall material at the hyphal tips regulated by the coordinated activity of cytoskeletal proteins ...

journal_title：Molecular microbiology

authors： Ultee E,Zhong X,Shitut S,Briegel A,Claessen D

更新日期：2020-12-05 00:00:00

abstract：:CTXphi is a filamentous phage that encodes cholera toxin, one of the principal virulence factors of Vibrio cholerae. CTXphi is unusual among filamentous phages because it can either replicate as a plasmid or integrate into the V. cholerae chromosome at a specific site. The CTXphi genome has two regions, the 'core' and...

journal_title：Molecular microbiology

authors： Waldor MK,Rubin EJ,Pearson GD,Kimsey H,Mekalanos JJ

更新日期：1997-06-01 00:00:00

abstract：:Transfer RNAs (tRNAs) are the macromolecules that transfer activated amino acids from aminoacyl-tRNA synthetases to the ribosome, where they are used for the mRNA guided synthesis of proteins. Transfer RNAs are ancient molecules, perhaps even predating the existence of the translation machinery. Albeit old, these mole...

journal_title：Molecular microbiology

authors： Katz A,Elgamal S,Rajkovic A,Ibba M

更新日期：2016-08-01 00:00:00

abstract：:Multicopy dnaA(Ts) strains carrying the dnaA5 or dnaA46 allele are high-temperature resistant but are cold sensitive for colony formation. The DnaA5 and DnaA46 proteins both have an A184-->V change in the ATP binding motif of the protein, but they also have one additional mutation. The mutations were separated, and it...

journal_title：Molecular microbiology

authors： Nyborg M,Atlung T,Skovgaard O,Hansen FG

更新日期：2000-03-01 00:00:00

abstract：:The tetA(L) gene of Bacillus subtilis encodes a transmembrane protein that can function as a Tc-metal/H+ antiporter, conferring low-level resistance to tetracycline. The TetA(L) coding sequence is preceded by a leader region that contains a 20-amino-acid open reading frame and an appropriately spaced ribosome binding ...

journal_title：Molecular microbiology

authors： Stasinopoulos SJ,Farr GA,Bechhofer DH

更新日期：1998-12-01 00:00:00