Non-canonical roles of tRNAs and tRNA mimics in bacterial cell biology.

Abstract:

:Transfer RNAs (tRNAs) are the macromolecules that transfer activated amino acids from aminoacyl-tRNA synthetases to the ribosome, where they are used for the mRNA guided synthesis of proteins. Transfer RNAs are ancient molecules, perhaps even predating the existence of the translation machinery. Albeit old, these molecules are tremendously conserved, a characteristic that is well illustrated by the fact that some bacterial tRNAs are efficient and specific substrates of eukaryotic aminoacyl-tRNA synthetases and ribosomes. Considering their ancient origin and high structural conservation, it is not surprising that tRNAs have been hijacked during evolution for functions outside of translation. These roles beyond translation include synthetic, regulatory and information functions within the cell. Here we provide an overview of the non-canonical roles of tRNAs and their mimics in bacteria, and discuss some of the common themes that arise when comparing these different functions.

journal_name

Mol Microbiol

journal_title

Molecular microbiology

authors

Katz A,Elgamal S,Rajkovic A,Ibba M

doi

10.1111/mmi.13419

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

545-58

issue

4

eissn

0950-382X

issn

1365-2958

journal_volume

101

pub_type

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