Cold-regulated genes under control of the cold sensor Hik33 in Synechocystis.

Abstract:

:A histidine kinase, Hik33, appears to sense decreases in temperature and to regulate the expression of certain cold-inducible genes in the cyanobacterium Synechocystis sp. PCC6803. To examine the role of Hik33 in the regulation of gene expression, we analysed a DeltaHik33 mutant using the DNA microarray technique. In wild-type cells, genes that were strongly induced at low temperature encoded proteins that were predominantly subunits of the transcriptional and translational machinery. Most cold-repressible genes encoded components of the photosynthetic machinery. Mutation of the hik33 gene suppressed the expression of some of these cold-regulated genes, which could be divided into three groups according to the effect of the mutation of hik33. In the first group, regulation of gene expression by low temperature was totally abolished; in the second group, the extent of such regulation was reduced by half; and, in the third group, such regulation was totally unaffected. These results suggest that expression of the genes in the first group is regulated solely by Hik33, expression of genes in the third group is regulated by an as yet unidentified cold sensor, and expression of genes in the second group is regulated by both these cold sensors.

journal_name

Mol Microbiol

journal_title

Molecular microbiology

authors

Suzuki I,Kanesaki Y,Mikami K,Kanehisa M,Murata N

doi

10.1046/j.1365-2958.2001.02379.x

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

235-44

issue

1

eissn

0950-382X

issn

1365-2958

pii

mmi2379

journal_volume

40

pub_type

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