Disruption of the GABA shunt affects mitochondrial respiration and virulence in the cereal pathogen Fusarium graminearum.

abstract：:The interaction of Neisseria meningitidis with the meninges that surround and protect the brain is a pivotal event in the progression of bacterial meningitis. Two models of the human meninges were established in vitro, using (i) sections of fresh human brain and (ii) cultures of viable cells grown from human meningiom...

journal_title：Molecular microbiology

authors： Hardy SJ,Christodoulides M,Weller RO,Heckels JE

更新日期：2000-05-01 00:00:00

abstract：:A 1.2kb DNA fragment was cloned from Synechococcus sp. PCC7942, which is able phenotypically to complement a phoR creC Escherichia coli mutant for the expression of alkaline phosphatase. A 2.5 kb DNA fragment encompassing the putative gene was then cloned and its complete nucleotide sequence determined. Nucleotide seq...

journal_title：Molecular microbiology

authors： Aiba H,Nagaya M,Mizuno T

更新日期：1993-04-01 00:00:00

abstract：:Among the iron-sulphur cluster assembly proteins encoded by gene cluster iscSUA-hscBA-fdx in Escherichia coli, IscA has a unique and strong iron binding activity and can provide iron for iron-sulphur cluster assembly in proteins in vitro. Deletion of IscA and its paralogue SufA results in an E. coli mutant that fails ...

journal_title：Molecular microbiology

authors： Tan G,Cheng Z,Pang Y,Landry AP,Li J,Lu J,Ding H

更新日期：2014-08-01 00:00:00

abstract：:The recent emergence of indolent and rapidly fatal drug-resistant strains of Mycobacterium tuberculosis has renewed interest in defining the molecular mechanisms of drug resistance in the tubercle bacilli. In this report, we have examined the mechanism of resistance to streptomycin (Sm) in M. tuberculosis through the ...

journal_title：Molecular microbiology

authors： Nair J,Rouse DA,Bai GH,Morris SL

更新日期：1993-11-01 00:00:00

abstract：:Initiation and re-initiation of chromosomal DNA replication in bacteria rely on divergent multiprotein assemblies, which direct the functional delivery of the replicative helicase on single-stranded DNA (ssDNA) at specific sites. These two processes are triggered either at the single chromosomal origin oriC or at arre...

journal_title：Molecular microbiology

authors： Bruand C,Velten M,McGovern S,Marsin S,Sérèna C,Ehrlich SD,Polard P

更新日期：2005-02-01 00:00:00

abstract：:Polymorphonuclear neutrophils are the most important mammalian host defence cells against infections with Pseudomonas aeruginosa. Screening of a signature tagged mutagenesis library of the non-piliated P. aeruginosa strain TBCF10839 uncovered that transposon inactivation of its pilY1 gene rendered the bacterium more r...

journal_title：Molecular microbiology

authors： Bohn YS,Brandes G,Rakhimova E,Horatzek S,Salunkhe P,Munder A,van Barneveld A,Jordan D,Bredenbruch F,Häussler S,Riedel K,Eberl L,Jensen PØ,Bjarnsholt T,Moser C,Hoiby N,Tümmler B,Wiehlmann L

更新日期：2009-02-01 00:00:00

abstract：:OmpR activates expression of the two-component regulatory system located on Salmonella pathogenicity island 2 (SPI-2) that controls the expression of a type III secretion system, as well as many other genes required for systemic infection in mice. Measurements of SsrA and SsrB protein levels under different growth con...

journal_title：Molecular microbiology

authors： Feng X,Walthers D,Oropeza R,Kenney LJ

更新日期：2004-11-01 00:00:00

abstract：:Many fungi undergo a morphological transition to filamentous growth in response to limiting nutrient conditions. Constitutively elongated Saccharomyces cerevisiae mutants (elm) have been isolated; the ELM1 gene encodes a putative serine/threonine protein kinase. A novel allele, elm1-15, has been isolated in an S288C-d...

journal_title：Molecular microbiology

authors： Garrett JM

更新日期：1997-11-01 00:00:00

abstract：:Escherichia coli loses its rod shape by inactivation of PBP2 (penicillin-binding protein 2), target of the beta-lactam mecillinam. Under these conditions, cell division is blocked in rich medium. Division in the absence of PBP2 activity is restored (and resistance to mecillinam is conferred) when the three cell divisi...

journal_title：Molecular microbiology

authors： Navarro F,Robin A,D'Ari R,Joseleau-Petit D

更新日期：1998-08-01 00:00:00

abstract：:Expression of Escherichia coli hupA and hupB, the structural genes encoding the most abundant nucleoid-associated proteins HUalpha and HUbeta has been studied during cold shock. This article demonstrates that: (i) transcriptional expression of hupA is blocked following a sudden temperature downshift (from 37 degrees C...

journal_title：Molecular microbiology

authors： Giangrossi M,Giuliodori AM,Gualerzi CO,Pon CL

更新日期：2002-04-01 00:00:00

abstract：:Avermectins produced by Streptomyces avermitilis are effective anthelmintic agents. The autoregulatory signalling molecule that triggers avermectin biosynthesis is a novel butenolide-type molecule, avenolide, rather than common γ-butyrolactones (GBLs). We identified AvaR2, a pseudo GBL receptor homologue, as an import...

journal_title：Molecular microbiology

authors： Zhu J,Sun D,Liu W,Chen Z,Li J,Wen Y

更新日期：2016-11-01 00:00:00

abstract：:Pseudomonas syringae pv. syringae cell densities fluctuate regularly during host plant colonization. Previously we identified nine genes dependent on the quorum-sensing-associated luxR homolog ahlR during epiphytic and apoplastic stages of host colonization. Yet their contributions to host colonization remain obscure,...

journal_title：Molecular microbiology

authors： Scott RA,Lindow SE

更新日期：2016-03-01 00:00:00

abstract：:Staphylococcus aureus is a leading cause of infective endocarditis (IE). Platelet activation promoted by S. aureus resulting in aggregation and thrombus formation is an important step in the pathogenesis of IE. Here, we report that the fibrinogen/fibronectin-binding proteins FnBPA and FnBPB are major platelet-activati...

journal_title：Molecular microbiology

authors： Fitzgerald JR,Loughman A,Keane F,Brennan M,Knobel M,Higgins J,Visai L,Speziale P,Cox D,Foster TJ

更新日期：2006-01-01 00:00:00

abstract：:The assembly of the class 5 colonization factor antigen I (CFA/I) fimbriae of enterotoxigenic E. coli was proposed to proceed via the alternate chaperone-usher pathway. Here, we show that in the absence of the chaperone CfaA, CfaB, the major pilin subunit of CFA/I fimbriae, is able to spontaneously refold and polymeri...

journal_title：Molecular microbiology

authors： Bao R,Liu Y,Savarino SJ,Xia D

更新日期：2016-12-01 00:00:00

abstract：:A biochemical approach to identify proteins with high affinity for choline-containing pneumococcal cell walls has allowed the localization, cloning and sequencing of a gene (lytC ) coding for a protein that degrades the cell walls of Streptococcus pneumoniae. The lytC gene is 1506 bp long and encodes a protein (LytC) ...

journal_title：Molecular microbiology

authors： García P,Paz González M,García E,García JL,López R

更新日期：1999-07-01 00:00:00

abstract：:We have determined the sizes of the chromosomes of six Bacillus cereus strains (range 2.4-4.3 Mb) and constructed a physical map of the smallest B. cereus chromosome (2.4 Mb). This map was compared to those of the chromosomes of four B. cereus strains and one B. thuringiensis strain previously determined to be 5.4-6.3...

journal_title：Molecular microbiology

authors： Carlson CR,Kolstø AB

更新日期：1994-07-01 00:00:00

abstract：:Aspergillus nidulans was used as a model organism to investigate the fungal propionate metabolism and the mechanism of growth inhibition by propionate. The fungus is able to grow slowly on propionate as sole carbon and energy source. Propionate is oxidized to pyruvate via the methylcitrate cycle. The key enzyme methyl...

journal_title：Molecular microbiology

authors： Brock M,Fischer R,Linder D,Buckel W

更新日期：2000-03-01 00:00:00

abstract：:Candida albicans hypha formation which has been stimulated via the Ras1-cAMP-Efg1 signalling cascade is inhibited by farnesol, a C. albicans autoregulatory factor, and small molecules such as dodecanol. In cultures containing farnesol or dodecanol, hypha formation was restored upon addition of dibutyryl-cAMP. The CAI4...

journal_title：Molecular microbiology

authors： Davis-Hanna A,Piispanen AE,Stateva LI,Hogan DA

更新日期：2008-01-01 00:00:00

abstract：:The unfolded protein response (UPR) is an important stress signalling pathway involved in the cellular development and environmental adaptation of fungi. We investigated the importance of the UPR pathway in the pathogenicity of the plant necrotrophic fungus Alternaria brassicicola, which causes black spot disease on a...

journal_title：Molecular microbiology

authors： Joubert A,Simoneau P,Campion C,Bataillé-Simoneau N,Iacomi-Vasilescu B,Poupard P,François JM,Georgeault S,Sellier E,Guillemette T

更新日期：2011-03-01 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) is the causative agent of the human disease Tuberculosis, and remains a worldwide health threat responsible for ∼1.7 million deaths annually. During infection, Mtb prevents acidification of the engulfing phagosome, thus blocking endocytic progression and eventually leading to stable re...

journal_title：Molecular microbiology

authors： Mann FM,VanderVen BC,Peters RJ

更新日期：2011-03-01 00:00:00

abstract：:Metabolic adaptations are critical to the ability of bacterial pathogens to grow within host cells and are normally preceded by sensing of host-specific metabolic signals, which in turn can influence the pathogen's virulence state. Previously, we reported that the intracellular bacterial pathogen Listeria monocytogene...

journal_title：Molecular microbiology

authors： Lobel L,Sigal N,Borovok I,Belitsky BR,Sonenshein AL,Herskovits AA

更新日期：2015-02-01 00:00:00

abstract：:The sensor kinase/response regulator system KdpD/KdpE of Escherichia coli regulates the expression of the kdpFABC operon, which encodes the high affinity K+ transport system KdpFABC. The membrane-bound sensor kinase KdpD consists of four transmembrane domains, a large cytoplasmic N-terminal domain and a cytoplasmic C-...

journal_title：Molecular microbiology

authors： Heermann R,Fohrmann A,Altendorf K,Jung K

更新日期：2003-02-01 00:00:00

abstract：:XylR is a σ⁵⁴-dependent transcriptional factor of Pseudomonas putida that activates the Pu promoter of the TOL plasmid upon binding its natural effector, m-xylene. The search for mutants of the signal-sensing module of XylR that respond to the xenobiotic compound 2,4-dinitrotoluene recurrently yields protein variants ...

journal_title：Molecular microbiology

authors： de Las Heras A,de Lorenzo V

更新日期：2011-03-01 00:00:00

abstract：:Ustilago maydis is able to initiate pathogenic development after fusion of two haploid cells with different mating type. On the maize leaf surface, the resulting dikaryon switches to filamentous growth, differentiates appressoria and penetrates the host. Here, we report on the plant signals required for filament forma...

journal_title：Molecular microbiology

authors： Mendoza-Mendoza A,Berndt P,Djamei A,Weise C,Linne U,Marahiel M,Vranes M,Kämper J,Kahmann R

更新日期：2009-02-01 00:00:00

abstract：:NalC is a TetR type regulator that represses the multidrug efflux pump MexAB-OprM in Pseudomonas aeruginosa. Here we explain the mechanism of NalC-mediated regulation of MexAB-OprM. We show that NalC non-covalently binds chlorinated phenols and chemicals containing chlorophenol side-chains such as triclosan. NalC-chlo...

journal_title：Molecular microbiology

authors： Ghosh S,Cremers CM,Jakob U,Love NG

更新日期：2011-03-01 00:00:00

abstract：:A number of eukaryotic proteins are already known to orchestrate key steps of mRNA metabolism and translation via interactions with the 5' m7GpppN cap. We have characterized a new type of histidine triad (HIT) motif protein (Nhm1) that co-purifies with the cap-binding complex eIF4F of Schizosaccharomyces pombe. Nhm1 i...

journal_title：Molecular microbiology

authors： Salehi Z,Geffers L,Vilela C,Birkenhäger R,Ptushkina M,Berthelot K,Ferro M,Gaskell S,Hagan I,Stapley B,McCarthy JE

更新日期：2002-10-01 00:00:00

abstract：:Leishmania parasites target macrophages in their mammalian hosts and proliferate within the mature phagolysosome compartment of these cells. Intracellular amastigote stages are dependent on sugars as a major carbon source in vivo, but retain the capacity to utilize other carbon sources. To investigate whether amastigo...

journal_title：Molecular microbiology

authors： Saunders EC,Naderer T,Chambers J,Landfear SM,McConville MJ

更新日期：2018-04-01 00:00:00

abstract：:A histidine kinase, Hik33, appears to sense decreases in temperature and to regulate the expression of certain cold-inducible genes in the cyanobacterium Synechocystis sp. PCC6803. To examine the role of Hik33 in the regulation of gene expression, we analysed a DeltaHik33 mutant using the DNA microarray technique. In ...

journal_title：Molecular microbiology

authors： Suzuki I,Kanesaki Y,Mikami K,Kanehisa M,Murata N

更新日期：2001-04-01 00:00:00

abstract：:In Escherichia coli, RecA protein regulates the DNA damage-inducible survival-enhancing SOS response. Mutant allele recA730, which causes constitutive SOS expression, is lethal at high temperatures in B/r, a derivative of wild-type B, but not in K-12 or in certain B/r--K-12 hybrids. We present evidence that killing is...

journal_title：Molecular microbiology

authors： Kirchner J,Lim D,Witkin EM,Garvey N,Roegner-Maniscalco V

更新日期：1992-10-01 00:00:00

abstract：:Two papers in this issue of Molecular Microbiology from Carol Gross and colleagues describe experiments that investigate how two alternative Escherichia coli sigma proteins recognize target promoter -10 regions. A combination of genetics, biochemistry and bioinformatics is used to show that determinants in two adjacen...

journal_title：Molecular microbiology

authors： Busby SJ

更新日期：2009-05-01 00:00:00