Abstract:
:Heteroduplexes between the DNA molecules of 12 lambdoid phages were analysed by electron microscopy. The positions of the regions of base sequence homology between the DNA molecules divide them into 35 segments, most of which have a number of alternative forms (alleles), which in general must be functionally homologous but which differ in base sequence and length. The positions of the boundaries between segments in phage lambda show that each segment is probably a gene or a group of genes, and that each phage genome is a different combination of the alleles of the segments. The frequency of the occurrence of the different alleles indicates that the total number in the natural population may be small. The different combinations of alleles of separate segments, found among the phages, indicate the exchange of segments between the phages during their evolution.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Highton PJ,Chang Y,Myers RJdoi
10.1111/j.1365-2958.1990.tb00712.xsubject
Has Abstractpub_date
1990-08-01 00:00:00pages
1329-40issue
8eissn
0950-382Xissn
1365-2958journal_volume
4pub_type
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