Genetic linkage analyses redefine the roles of PfCRT and PfMDR1 in drug accumulation and susceptibility in Plasmodium falciparum.

abstract：:While Vipp1 (also known as IM30) clearly is essential for proper biogenesis of thylakoid membranes in chloroplasts and cyanobacteria, the exact function of Vipp1/IM30 still remains unclear. The recent in vivo study of Gutu et al. now demonstrates that Vipp1/IM30 forms localized puncta specifically at highly curved mem...

journal_title：Molecular microbiology

authors： Junglas B,Schneider D

更新日期：2018-04-01 00:00:00

abstract：:The Salmonella pathogenicity island (SPI-1) encodes approximately 35 proteins involved in assembly of a type III secretion system (T3SS) which endows Salmonella with the ability to invade eukaryotic cells. We have discovered a novel SPI-1 gene, invR, which expresses an abundant small non-coding RNA (sRNA). The invR ge...

journal_title：Molecular microbiology

authors： Pfeiffer V,Sittka A,Tomer R,Tedin K,Brinkmann V,Vogel J

更新日期：2007-12-01 00:00:00

abstract：:The Escherichia coli DNA glycosylase Mug excises 3,N(4)-ethenocytosines (epsilon C) and uracils from DNA, but its biological function is obscure. This is because epsilon C is not found in E. coli DNA, and uracil-DNA glycosylase (Ung), a distinct enzyme, is much more efficient at removing uracils from DNA than Mug. We ...

journal_title：Molecular microbiology

authors： Mokkapati SK,Fernández de Henestrosa AR,Bhagwat AS

更新日期：2001-09-01 00:00:00

abstract：:The spoIIIG gene encodes a sigma factor that determines prespore-specific gene expression during sporulation in Bacillus subtilis. Correct spatial and temporal expression of the spoIIIG gene depends on a number of other sporulation (spo) genes, but only one of these genes, spoIIIE, has a specific effect on spoIIIG exp...

journal_title：Molecular microbiology

authors： Foulger D,Errington J

更新日期：1989-09-01 00:00:00

abstract：:Prior studies have shown that the catalase-deficient pathogen Streptococcus pyogenes (group A streptococcus) has a robust ability to resist oxidative stress that partially involves the transcriptional regulator PerR. However, the extent of the PerR regulon and the contribution of the members of this regulon to virulen...

journal_title：Molecular microbiology

authors： Brenot A,King KY,Caparon MG

更新日期：2005-01-01 00:00:00

abstract：:Yersinia enterocolitica produces heat-stable enterotoxin (Y-ST) as one of its virulence factors. The yst gene, however, frequently and spontaneously becomes inactive (silent) during storage, which is accompanied by concurrent changes in some biological properties such as colony morphology, growth rate, carbon fermenta...

journal_title：Molecular microbiology

authors： Nakao H,Watanabe H,Nakayama S,Takeda T

更新日期：1995-12-01 00:00:00

abstract：:The bacteriocin pediocin PA-1 operon of Pediococcus acidilactici PAC1.0 encompasses four genes: pedA, pedB, pedC and pedD. Transcription of the operon results in the formation of two overlapping transcripts, probably originating from a single promoter upstream of pedA. The major transcript comprises pedA, pedB, and pe...

journal_title：Molecular microbiology

authors： Venema K,Kok J,Marugg JD,Toonen MY,Ledeboer AM,Venema G,Chikindas ML

更新日期：1995-08-01 00:00:00

abstract：:Initial observations that the budding yeast Saccharomyces cerevisiae can be induced to undergo a form of cell death exhibiting typical markers of apoptosis has led to the emergence of a thriving new field of research. Since this discovery, a number of conserved pro- and antiapoptotic proteins have been identified in y...

journal_title：Molecular microbiology

authors： Gourlay CW,Du W,Ayscough KR

更新日期：2006-12-01 00:00:00

abstract：:We have cloned a gene encoding a polygalacturonase (PG) in the filamentous fungus Aspergillus niger RH5344. The structural gene comprises 1141 bp coding for 362 amino acids and the open reading frame is disrupted by one intron of 52 bp. Eukaryotic consensus sequences for transcription regulation are found only in devi...

journal_title：Molecular microbiology

authors： Ruttkowski E,Khanh NQ,Wientjes FJ,Gottschalk M

更新日期：1991-06-01 00:00:00

abstract：:Many bacteria colonize surfaces and transition to a sessile mode of growth. The plant pathogen Agrobacterium tumefaciens produces a unipolar polysaccharide (UPP) adhesin at single cell poles that contact surfaces. Here we report that elevated levels of the intracellular signal cyclic diguanosine monophosphate (c-di-GM...

journal_title：Molecular microbiology

authors： Xu J,Kim J,Koestler BJ,Choi JH,Waters CM,Fuqua C

更新日期：2013-09-01 00:00:00

abstract：:Recent footprinting, sedimentation and neutron-scattering results obtained in vivo or on pre-translocation and post-translocation ribosomal complexes are integrated with cross-linking and immunoelectron microscopy information. It is proposed that the 30S subunit pulses during translocation and that its pre- and post-t...

journal_title：Molecular microbiology

authors： Laughrea M

更新日期：1994-03-01 00:00:00

abstract：:mscL encodes a channel in Escherichia coli that is opened by membrane stretch force, probably serving as an osmotic gauge. Sequences more or less similar to mscL are found in other bacteria, but the degree of conserved function has been unclear. We subcloned and expressed these putative homologues in E. coli and exami...

journal_title：Molecular microbiology

authors： Moe PC,Blount P,Kung C

更新日期：1998-05-01 00:00:00

abstract：:Thymidylate, an essential building block of DNA, is synthesized either from deoxyuridylate by thymidylate synthase (TS) or thymidine (dT) by thymidine kinase (TK). Thymidylate kinase (TMPK) phosphorylates dTMP to dTTP. Thymidine phosphorylase (TP) catalyses reversible phosphorolysis of dT. Using transposon mutagenesis...

journal_title：Molecular microbiology

authors： Wang L,Hames C,Schmidl SR,Stülke J

更新日期：2010-09-01 00:00:00

abstract：:Changes in the mRNA levels of two Mycobacterium tuberculosis genes (fbpB known as antigen 85B, and hspX known as Acr) were studied in infected human monocytes. Antigen 85B is an enzyme involved in cell wall biosynthesis and is also a major target of the immune response. Acr is a stress protein believed to be involved ...

journal_title：Molecular microbiology

authors： Wilkinson RJ,DesJardin LE,Islam N,Gibson BM,Kanost RA,Wilkinson KA,Poelman D,Eisenach KD,Toossi Z

更新日期：2001-02-01 00:00:00

abstract：:ClpP is the proteolytic subunit of the ATP-dependent Clp protease in eubacteria, mammals and plant chloroplasts. Cyanobacterial ClpP protein is encoded by a multigene family, producing up to four distinct isozymes. We have examined the importance of the first ClpP protein (ClpP1) isolated from the cyanobacterium Synec...

journal_title：Molecular microbiology

authors： Porankiewicz J,Schelin J,Clarke AK

更新日期：1998-07-01 00:00:00

abstract：:Listeria monocytogenes is a Gram-positive intracellular parasite and the causative organism of human listeriosis. In this article we demonstrate that L. monocytogenes encodes a functional member of the CodY family of global regulatory proteins that is responsive to both GTP and branched chain amino acids. By transcrip...

journal_title：Molecular microbiology

authors： Bennett HJ,Pearce DM,Glenn S,Taylor CM,Kuhn M,Sonenshein AL,Andrew PW,Roberts IS

更新日期：2007-03-01 00:00:00

abstract：:We determined the genome-wide environmental stress response (ESR) expression profile of Candida glabrata, a human pathogen related to Saccharomyces cerevisiae. Despite different habitats, C. glabrata, S. cerevisiae, Schizosaccharomyces pombe and Candida albicans have a qualitatively similar ESR. We investigate the fun...

journal_title：Molecular microbiology

authors： Roetzer A,Gregori C,Jennings AM,Quintin J,Ferrandon D,Butler G,Kuchler K,Ammerer G,Schüller C

更新日期：2008-08-01 00:00:00

abstract：:The stable RNA promoters of Escherichia coli are exquisitely sensitive to variations in the superhelical density of DNA. Previously, we have shown that binding of the DNA architectural protein FIS at the upstream activating sequences (UASs) of stable RNA promoters prevents the transcription complexes from inactivation...

journal_title：Molecular microbiology

authors： Rochman M,Blot N,Dyachenko M,Glaser G,Travers A,Muskhelishvili G

更新日期：2004-07-01 00:00:00

abstract：:The gene cbhA from the cellulolytic bacterium Cellulomonas fimi encodes a protein of 872 amino acids designated cellobiohydrolase A (CbhA). Mature CbhA contains 832 amino acid residues and has a predicted molecular mass of 85,349 Da. It is composed of five domains: an N-terminal catalytic domain, three repeated sequen...

journal_title：Molecular microbiology

authors： Meinke A,Gilkes NR,Kwan E,Kilburn DG,Warren RA,Miller RC Jr

更新日期：1994-05-01 00:00:00

abstract：:Ureaplasma urealyticum (U. urealyticum), belonging to the class Mollicutes, is a human pathogen colonizing the urogenital tract and causes among other things respiratory diseases in premature infants. We have studied the salvage of pyrimidine deoxynucleosides in U. urealyticum and cloned a key salvage enzyme, thymidin...

journal_title：Molecular microbiology

authors： Carnrot C,Wehelie R,Eriksson S,Bölske G,Wang L

更新日期：2003-11-01 00:00:00

abstract：:Protein kinase C constitutes a family of serine-threonine kinases found in all eukaryotes and implicated in a wide range of cellular functions, including regulation of cell growth, cellular differentiation and immunity. Here, we present three independent lines of evidence which indicate that protein kinase C is essent...

journal_title：Molecular microbiology

authors： Penn TJ,Wood ME,Soanes DM,Csukai M,Corran AJ,Talbot NJ

更新日期：2015-10-01 00:00:00

abstract：:Gene expression in the Leishmania is controlled post-transcriptionally, and is likely to be impacted by both 5' and 3' untranslated regions (UTRs). We have investigated the effects of trinucleotides in the AUG-proximal region (APR) (i.e. positions -3 to -1 upstream of an AUG) on two reporter genes in the context of an...

journal_title：Molecular microbiology

authors： Stanton JD,Mensa-Wilmot K

更新日期：2006-08-01 00:00:00

abstract：:The rfb (O antigen) gene cluster of group C2 Salmonella differs from that of group B in a central region of 12.4 kb: we report the sequencing of this region of strain M67 (group C2) and a subsequent comparison with the central region of strain LT2 (group B). We find a block of seven open reading frames unique to group...

journal_title：Molecular microbiology

authors： Brown PK,Romana LK,Reeves PR

更新日期：1992-05-01 00:00:00

abstract：:Mycoplasma agalactiae, an important pathogen of small ruminants, exhibits antigenic diversity by switching the expression of multiple surface lipoproteins called Vpmas (Variable proteins of M. agalactiae). Although phase variation has been shown to play important roles in many host-pathogen interactions, the biologica...

journal_title：Molecular microbiology

authors： Chopra-Dewasthaly R,Citti C,Glew MD,Zimmermann M,Rosengarten R,Jechlinger W

更新日期：2008-03-01 00:00:00

abstract：:Engulfment of the forespore by the mother cell is a universal feature of endosporulation. In Bacillus subtilis, the forespore protein SpoIIQ and the mother cell protein SpoIIIAH form a channel, essential for endosporulation, through which the developing spore is nurtured. The two proteins also form a backup system for...

journal_title：Molecular microbiology

authors： Serrano M,Crawshaw AD,Dembek M,Monteiro JM,Pereira FC,Pinho MG,Fairweather NF,Salgado PS,Henriques AO

更新日期：2016-04-01 00:00:00

abstract：:HapR is a quorum sensing-regulated transcription factor that represses the virulence cascade in Vibrio cholerae by binding to a specific site centred at -71 in the aphA promoter, ultimately preventing activation of the tcpPH promoter on the Vibrio pathogenicity island. In an effort to elucidate the mechanism by which ...

journal_title：Molecular microbiology

authors： Lin W,Kovacikova G,Skorupski K

更新日期：2007-05-01 00:00:00

abstract：:Many proteins have developed the potential to sequester a client polypeptide chain in its various folding states as a specific intermolecular ligand and, thus, exhibit the properties of a holding chaperone. The resulting complexes can be of a diverse nature in terms of structure and reaction dynamics and are character...

journal_title：Molecular microbiology

authors： Fischer G,Wawra S

更新日期：2006-09-01 00:00:00

abstract：:We show that Yersinia pestis and pesticin-sensitive isolates of Y. pseudotuberculosis possess a common 34 kbp DNA region that has all the hallmarks of a pathogenicity island and is inserted into different asparaginyl tRNA genes at different chromosomal locations in each species. This pathogenicity island (YP-HPI) is m...

journal_title：Molecular microbiology

authors： Hare JM,Wagner AK,McDonough KA

更新日期：1999-01-01 00:00:00

abstract：:NsrR is a nitric oxide (NO)-sensitive transcription repressor that controls NO metabolism in a wide range of bacteria. In Bacillus subtilis, NsrR represses transcription of the nitrite reductase (nasDEF) genes that are under positive control of the ResD-ResE two-component signal transduction system. Derepression is ac...

journal_title：Molecular microbiology

authors： Kommineni S,Yukl E,Hayashi T,Delepine J,Geng H,Moënne-Loccoz P,Nakano MM

更新日期：2010-12-01 00:00:00

abstract：:Micrococcus luteus secretes a small protein called Rpf, which has autocrine and paracrine signalling functions and is required for the resuscitation of dormant cells. Originally isolated from the supernatant of actively growing cultures, Rpf was also detected on the surface of actively growing bacteria. Most molecules...

journal_title：Molecular microbiology

authors： Mukamolova GV,Turapov OA,Kazarian K,Telkov M,Kaprelyants AS,Kell DB,Young M

更新日期：2002-11-01 00:00:00